Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Giriraj Sahu"'
Autor:
Xiaoqin Zhan, Hadhimulya Asmara, Ning Cheng, Giriraj Sahu, Eduardo Sanchez, Fang-Xiong Zhang, Gerald W. Zamponi, Jong M. Rho, Ray W. Turner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce e
Externí odkaz:
https://doaj.org/article/14f1b5ef2d044bbe97bc456fbccfe24c
Autor:
Giriraj Sahu, Ray W. Turner
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Neuronal signal transmission depends on the frequency, pattern, and timing of spike output, each of which are shaped by spike afterhyperpolarizations (AHPs). There are classically three post-spike AHPs of increasing duration categorized as fast, medi
Externí odkaz:
https://doaj.org/article/d06042649eac4641bb9bbcd2c9d3ed54
Autor:
Hadhimulya Asmara, Ileana Micu, Arsalan P. Rizwan, Giriraj Sahu, Brett A. Simms, Fang-Xiong Zhang, Jordan D. T. Engbers, Peter K. Stys, Gerald W. Zamponi, Ray W. Turner
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-15 (2017)
Abstract Calmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium channels of the Cav3 family have th
Externí odkaz:
https://doaj.org/article/6b30ca7a1d8445b281ceed3254df4263
Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability
Autor:
Giriraj Sahu, Rima-Marie Wazen, Pina Colarusso, S.R. Wayne Chen, Gerald W. Zamponi, Ray W. Turner
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2427-2442.e6 (2019)
Summary: The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine receptors (RyR). We used super-resolution and FRET microscopy to investigate the p
Externí odkaz:
https://doaj.org/article/dc84eac3b1d4469582aff646ffab951d
Autor:
Debanjan Tewari, Mohona Mukhopadhyay, Madhav Siva Nekkanti, Sirisha Vallabhaneni, Giriraj Sahu, Suresh Kumar Jetti, D.S. Preethidan, Amal Kanti Bera
Publikováno v:
Journal of Functional Foods, Vol 21, Iss , Pp 301-311 (2016)
Centella asiatica (CA) is commonly used as a leafy vegetable in many Asian countries. Consumption of CA is believed to prevent neuronal damage and improve brain function. The protective effect of CA on N2a cells were evaluated using ischaemia-reperfu
Externí odkaz:
https://doaj.org/article/089ac95e62044f668c7e46375485f6a1
Autor:
Giriraj Sahu, Amal Kanti Bera
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60506 (2013)
Ischemia is known to inhibit gap junction (GJ) mediated intercellular communication. However the detail mechanisms of this inhibition are largely unknown. In the present study, we determined the vulnerability of different cardiac GJ channels formed o
Externí odkaz:
https://doaj.org/article/7f0459cb9fa24ee4b136e1bc306bdf26
Autor:
Gerald W. Zamponi, Fang-Xiong Zhang, Eduardo Sanchez, Giriraj Sahu, Ning Cheng, Hadhimulya Asmara, Jong M. Rho, Xiaoqin Zhan, Ray W. Turner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Fragile X Syndrome results from a loss of Fragile X Mental Retardation Protein (FMRP). We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium current in cerebellar granule cells to produce mossy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b8a54f76dc69cf25782e0b197b2e0d
https://doaj.org/article/14f1b5ef2d044bbe97bc456fbccfe24c
https://doaj.org/article/14f1b5ef2d044bbe97bc456fbccfe24c
Autor:
Rima Marie Wazen, Lucy J Goudswaard, Ray W. Turner, Bartholomew S.J. Harvey, Alice Gregorie, Gemma Varley, Pina Colarusso, David N. Sheppard, Giriraj Sahu, Neil V. Marrion, James Higham
Publikováno v:
Molecular Pharmacology. 96:115-126
Three small conductance calcium-activated potassium channel (SK) subunits have been cloned and found to preferentially form heteromeric channels when expressed in a heterologous expression system. The original cloning of the gene encoding the interme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd450193e8c52c355a448563dd646dcf
https://doi.org/10.1124/mol.118.115634
https://doi.org/10.1124/mol.118.115634
Publikováno v:
The Journal of Neuroscience. 37:11255-11270
CaV1 L-type calcium channels are key to regulating neuronal excitability, with the range of functional roles enhanced by interactions with calmodulin, accessory proteins, or CaMKII that modulate channel activity. In hippocampal pyramidal cells, a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd21a3ee57c5204f06b9c432ac00a20
https://doi.org/10.1523/jneurosci.0967-17.2017
https://doi.org/10.1523/jneurosci.0967-17.2017
Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability
Autor:
Ray W. Turner, S.R. Wayne Chen, Gerald W. Zamponi, Pina Colarusso, Giriraj Sahu, Rima-Marie Wazen
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2427-2442.e6 (2019)
Summary: The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine receptors (RyR). We used super-resolution and FRET microscopy to investigate the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f71b808c2d61ba6ca12a413fc1e355
https://pubmed.ncbi.nlm.nih.gov/31461656
https://pubmed.ncbi.nlm.nih.gov/31461656