Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Girgis OBAID"'
Autor:
Girgis Obaid, Shazia Bano, Hanna Thomsen, Susan Callaghan, Nimit Shah, Joseph W. R. Swain, Wendong Jin, Xiadong Ding, Colin G. Cameron, Sherri A. McFarland, Juwell Wu, Mark Vangel, Svetla Stoilova‐McPhie, Jie Zhao, Mari Mino‐Kenudson, Charles Lin, Tayyaba Hasan
Publikováno v:
Advanced Science, Vol 9, Iss 24, Pp n/a-n/a (2022)
Abstract Desmoplasia is characteristic of pancreatic ductal adenocarcinoma (PDAC), which exhibits 5‐year survival rates of 3%. Desmoplasia presents physical and biochemical barriers that contribute to treatment resistance, yet depleting the stroma
Externí odkaz:
https://doaj.org/article/0670866fd506442c8ba84eb912ca8dbe
Autor:
Chanda Bhandari, John Fakhry, Menitte Eroy, Jane Junghwa Song, Kimberley Samkoe, Tayyaba Hasan, Kenneth Hoyt, Girgis Obaid
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Fluorescence image-guided surgery (IGS) using antibody conjugates of the fluorophore IRDye800CW have revolutionized the surgical debulking of tumors. Cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, conjugated to IRDye8
Externí odkaz:
https://doaj.org/article/3f8234b1c7cf4b5b93f65c7332661e5e
Autor:
Drashti Shah, Menitte Eroy, John Fakhry, Azophi Moffat, Kevin Fritz, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Girgis Obaid
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2426 (2022)
Osmium (Os)-based photosensitizers (PSs) exhibit unique broad, red-shifted absorption, favoring PDT activity at greater tissue depths. We recently reported on a potent Os(II) PS, rac-[Os(phen)2(IP-4T)](Cl)2 (ML18J03) with submicromolar hypoxia activi
Externí odkaz:
https://doaj.org/article/e21ca653a6b24aca8bb09c3f5d9ce9b5
Autor:
Nimit Shah, John Squire, Mina Guirguis, Debabrata Saha, Kenneth Hoyt, Ken Kang-Hsin Wang, Vijay Agarwal, Girgis Obaid
Publikováno v:
Cancers, Vol 14, Iss 8, p 2004 (2022)
With the continued development of nanomaterials over the past two decades, specialized photonanomedicines (light-activable nanomedicines, PNMs) have evolved to become excitable by alternative energy sources that typically penetrate tissue deeper than
Externí odkaz:
https://doaj.org/article/0a7820212a464a01ae8fd61cee55351c
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 786 (2021)
The emergence of biomimetic nanotechnology has seen an exponential rise over the past decade with applications in regenerative medicine, immunotherapy and drug delivery. In the context of nanomedicines activated by near infrared (NIR) photodynamic pr
Externí odkaz:
https://doaj.org/article/72c5d1f6e6a9451984b141387e54096d
Autor:
Shazia Bano, Girgis Obaid, Joseph W. R. Swain, Marina Yamada, Brian W. Pogue, Kenneth Wang, Tayyaba Hasan
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 8, p 2390 (2020)
Receptor heterogeneity in cancer is a major limitation of molecular targeting for cancer therapeutics. Single-receptor-targeted treatment exerts selection pressures that result in treatment escape for low-receptor-expressing tumor subpopulations. To
Externí odkaz:
https://doaj.org/article/5b096276765d425ba4a267fc34c3d23b
Autor:
Mans Broekgaarden, Ahmed Alkhateeb, Shazia Bano, Anne-Laure Bulin, Girgis Obaid, Imran Rizvi, Tayyaba Hasan
Publikováno v:
Cancers, Vol 12, Iss 6, p 1401 (2020)
Extensive desmoplasia is a hallmark of pancreatic ductal adenocarcinoma (PDAC), which frequently associates with treatment resistance. Recent findings indicate that a combination of photodynamic therapy and the multi-kinase inhibitor cabozantinib ach
Externí odkaz:
https://doaj.org/article/8414431ac6594bb1b8df4ebb8232f72e
Autor:
Houston D. Cole, Menitte Eroy, John A. Roque, Ge Shi, Mina Guirguis, John Fakhry, Colin G. Cameron, Girgis Obaid, Sherri A. McFarland
Publikováno v:
Photochemistry and Photobiology. 99:751-760
Osmium (Os) based photosensitizers (PSs) are a unique class of nontetrapyrrolic metal-containing PSs that absorb red light. We recently reported a highly potent Os(II) PS, rac-[Os(phen)
Autor:
Brittany P. Rickard, Marta Overchuk, Girgis Obaid, Mustafa Kemal Ruhi, Utkan Demirci, Suzanne E. Fenton, Janine H. Santos, David Kessel, Imran Rizvi
Publikováno v:
Photochemistry and Photobiology. 99:448-468
Ovarian cancer is the most lethal gynecologic malignancy with a stubborn mortality rate of ~65%. The persistent failure of multiline chemotherapy, and significant tumor heterogeneity, has made it challenging to improve outcomes. A target of increasin
Autor:
Sydney Formica, Tayyaba Hasan, Wonho Zhung, Stacey Grimaldo Garcia, Margaret Elizabeth Stanley, Girgis Obaid, Mohammad A. Saad
Publikováno v:
Molecular Pharmaceutics. 19:2549-2563
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by increased levels of desmoplasia that contributes to reduced drug delivery and poor treatment outcomes. In PDAC, the stromal content can account for up to 90% of the tot