Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gireesh C Kumaran"'
Autor:
Hayley Farmer, Timothy H Ward, Andrew Taylor, Helen Turner, Nita Fisher, Danielle Shaw, Gordon C Jayson, Mark N. K. Saunders, Nigel K Smith, Caleb Roberts, Sarah Halford, Yvonne Watson, Andrew R Clamp, Laura Horsley, Jeffrey Cummings, Paula Potter, Mark R. Middleton, Caroline Dive, Philip J. Hogg, Geoff J M Parker, Gireesh C Kumaran, Ross A. Little, Jurjees Hasan, Adrian L. Harris, Alison Backen, Gavin Halbert, Martin J Dawson, Jon Smythe
Publikováno v:
Cancer Chemotherapy and Pharmacology. 72:1343-1352
Background: 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) is a water-soluble mitochondrial toxin that binds to adenine nucleotide translocase in the inner mitochondrial membrane, thereby targeting cell proliferation. This phase 1 study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f15c9fc243a2ec97c93a8a308a2b3c
https://doi.org/10.1007/s00280-013-2320-9
https://doi.org/10.1007/s00280-013-2320-9
Autor:
Andrew R Clamp, Saran Evans, Ying Kiat Zee, Gordon C Jayson, Richard S. Welch, Claire Mitchell, Gireesh C Kumaran, Jurjees Hasan, Richard Griffiths
Publikováno v:
International Journal of Gynecologic Cancer. 21:58-65
Background:Platinum-resistant and refractory cancers of the ovary, fallopian tube, and peritoneum have a poor prognosis, yet in some cases, they can respond to multiple lines of chemotherapy. Uncertainty remains over optimal drug choice and when ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8475f78c23dc70a3637f6a48b67299
https://doi.org/10.1097/igc.0b013e3182049273
https://doi.org/10.1097/igc.0b013e3182049273
Publikováno v:
British Journal of Cancer
Ovarian cancer continues to be a major cause of morbidity and mortality in women. Antiangiogenic treatments have emerged as a promising strategy to treat ovarian cancer. This article reviews the rationale supporting the use of antiangiogenic treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa9c5d5bd7123290cf4c3d20327419b
http://europepmc.org/articles/PMC2634670
http://europepmc.org/articles/PMC2634670
Autor:
Andrew R Clamp, Gordon C Jayson, Leila Khoja, Ric Swindell, Jurjees Hasan, Gireesh C Kumaran, Nishanth Murukesh, Gregory Wilson, Ying-Kiat Zee, Mark P Saunders, Juan W. Valle
Publikováno v:
Journal of clinical gastroenterology. 48(5)
BACKGROUND:: The vascular endothelial growth factor pathway is strongly implicated in cancer-related angiogenesis. Antiangiogenic agents such as bevacizumab commonly cause hypertension (HTN) and proteinuria (PTN), which may be biomarkers of response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b730faae183cc56ce291888d63bc801
https://pubmed.ncbi.nlm.nih.gov/24153157
https://pubmed.ncbi.nlm.nih.gov/24153157
Publikováno v:
Clinical medicine (London, England). 8(4)
Kumaran, Gireesh Clamp, Andrew R Jayson, Gordon C England Clinical medicine (London, England) Clin Med. 2008 Aug;8(4):455-8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c28ee10a5965583b48d729e092d2a2
https://pubmed.ncbi.nlm.nih.gov/18724620
https://pubmed.ncbi.nlm.nih.gov/18724620
Autor:
Andrew R Clamp, L. McGuigan, Y. K. Zee, Mark R. Middleton, Gordon C Jayson, Philip J. Hogg, A. Jackson, Geoffrey J. M. Parker, Al Harris, Gireesh C Kumaran
Publikováno v:
Journal of Clinical Oncology. 28:TPS167-TPS167
TPS167 Background: 4-(N-(S- glutathionylacetyl)amino)phenylarsonous acid (GSAO) is a new water-soluble organoarsenical that selectively inhibits proliferating endothelial cells (EC) in vitro and angiogenesis and tumor growth in human tumor xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3e98438dc80c3387a98095b3a610ce
https://doi.org/10.1200/jco.2010.28.15_suppl.tps167
https://doi.org/10.1200/jco.2010.28.15_suppl.tps167
Autor:
Y. K. Zee, Gordon C Jayson, N. Murukesh, Jurjees Hasan, Godfrey E Wilson, Ric Swindell, Andrew R Clamp, Gireesh C Kumaran, Mark P Saunders, Juan W. Valle
Publikováno v:
ResearcherID
e13580 Background: There are no known predictive markers for the efficacy of vascular endothelial growth factor (VEGF) pathway-targeted therapies. HTN and PTN are known side effects of anti-VEGF therapy. The aim of our study was to assess if HTN and/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff4d33f784e3de6c276d911761f0e83
https://doi.org/10.1200/jco.2010.28.15_suppl.e13580
https://doi.org/10.1200/jco.2010.28.15_suppl.e13580