Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture

Autor: Patrick Evans, Jay A. Tischfield, Anuar Konkashbaev, Richard Delorme, Sandra Catalina Mesa Restrepo, Margaret A. Richter, Gregory L. Hanna, Allan L. Naarden, Michele T. Pato, Jian Yang, Denise A. Chavira, Damiaan Denys, Paul Sandor, Michael A. Jenike, Sian M. J. Hemmings, Paul D. Arnold, Stephan Ruhrmann, H.G.M. Westenberg, Yves Dion, Cathy L. Barr, Andres Ruiz-Linares, Brooke Sheppard, Leonhard Lennertz, Eske M. Derks, Lauren M. McGrath, Barbara Kremeyer, Marion Leboyer, Victor I. Reus, Cornelia Illmann, S. Evelyn Stewart, Dan J. Stein, Ana Gabriela Hounie, James T. McCracken, R. Kurlan, Chunyu Liu, Aline S. Sampaio, Thomas L. Lowe, Benjamin M. Neale, Yehuda Pollak, Desmond Campbell, Fabio Macciardi, Mary M. Robertson, Benjamin D. Greenberg, Ben A. Oostra, Rainald Moessner, Gary A. Heiman, Nuria Lanzagorta, Sylvain Chouinard, Rianne M. Blom, Karin Egberts, Carlos N. Pato, David V. Conti, Carol A. Mathews, Ying Wang, Marco A. Grados, Julio C. Cardona Silgado, S. Hong Lee, H. Müller, Eric R. Gamazon, Humberto Nicolini, Jan Smit, Euripedes Constantino Miguel, Jens R. Wendland, Cathy L. Budman, Laura Bellodi, Danielle Posthuma, Jubel Morgan, David R. Rosenberg, John Piacentini, Hans J. Grabe, Mark A. Riddle, Beatriz Camarena, Naomi R. Wray, Eric Strengman, Dennis L. Murphy, Simon Girard, Christine Lochner, Ruth D. Bruun, Joseph Jankovic, Edwin H. Cook, William M. McMahon, Scott L. Rauch, James F. Leckman, Peter Falkai, Fortu Benarroch, Christopher K. Edlund, Gabriel Bedoya Berrío, Homero Vallada, Susanne Walitza, Nelson B. Freimer, Stephen A. Haddad, Yin Yao Shugart, Danielle C. Cath, Nancy J. Cox, Varda Gross-Tsur, Guy A. Rouleau, Bernadette Cullen, Michael H. Bloch, Dieter Deforce, David L. Pauls, Thomas V. Fernandez, Roel A. Ophoff, Filip Van Nieuwerburgh, Gerald Nestadt, Dongmei Yu, Helena Garrido, Robert A. King, James L. Kennedy, Clare L. Keenan, Lisa Osiecki, Jack Samuels, Jeremy Veenstra-VanderWeele, Ana V. Valencia Duarte, James A. Knowles, Patience J. Gallagher, Carolina Cappi, Maria Conceição do Rosário, Andrew J. Pakstis, Christopher Pittenger, Michael Wagner, Jeremiah M. Scharf, Daniel A. Geller, Vladimir Coric, Tobias J. Renner, Oscar J. Bienvenu, Roxana Romero, William Cornejo Ochoa, Peter Heutink, Lea K. Davis, Harvey S. Singer, Maria Cristina Cavallini

Publikováno v: Davis, L K, Yu, D, Keenan, C L, Gamazon, E R, Konkashbaev, A I, Derks, E M, Neale, B M, Yang, J, Lee, S H, Evans, P, Barr, C L, Bellodi, L, Benarroch, F, Berrio, G B, Bienvenu, O J, Bloch, M H, Blom, R M, Bruun, R D, Budman, C L, Camarena, B, Campbell, D, Cappi, C, Cardona Silgado, J C, Cath, D C, Cavallini, M C, Chavira, D A, Chouinard, S, Conti, D V, Cook, E H, Coric, V, Cullen, B A, Deforce, D, Delorme, R, Dion, Y, Edlund, C K, Egberts, K, Falkai, P, Fernandez, T V, Gallagher, P J, Garrido, H, Geller, D, Girard, S L, Grabe, H J, Grados, M A, Greenberg, B D, Gross-Tsur, V, Haddad, S, Heiman, G A, Hemmings, S M, Hounie, A G, Illmann, C, Jankovic, J, Jenike, M A, Kennedy, J L, King, R A, Kremeyer, B, Kurlan, R, Lanzagorta, N, Leboyer, M, Leckman, J F, Lennertz, L, Liu, C, Lochner, C, Lowe, T L, Macciardi, F, McCracken, J T, McGrath, L M, Mesa Restrepo, S C, Moessner, R, Morgan, J, Muller, H, Murphy, D L, Naarden, A L, Ochoa, W C, Ophoff, R A, Osiecki, L, Pakstis, A J, Pato, M T, Piacentini, J, Pittenger, C, Pollak, Y, Rauch, S L, Renner, T J, Reus, V I, Richter, M A, Riddle, M A, Robertson, M M, Romero, R, Rosàrio, M C, Rosenberg, D, Rouleau, G A, Ruhrmann, S, Ruiz-Linares, A, Sampaio, A S, Samuels, J, Sandor, P, Sheppard, B, Singer, H S, Smit, J H, Stein, D J, Strengman, E, Tischfield, J A, Valencia Duarte, A V, Vallada, H, van Nieuwerburgh, F, Veenstra-Vanderweele, J, Walitza, S, Wang, Y, Wendland, J R, Westenberg, H G, Shugart, Y Y, Miguel, E C, McMahon, W, Wagner, M, Nicolini, H, Posthuma, D, Hanna, G L, Heutink, P, Denys, D, Arnold, P D, Oostra, B A, Nestadt, G, Freimer, N B, Pauls, D L, Wray, N R, Stewart, S E, Mathews, C A, Knowles, J A, Cox, N J & Scharf, J M 2013, ' Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture ', PLoS Genetics, vol. 9, no. 10, e1003864, pp. e1003864 . https://doi.org/10.1371/journal.pgen.1003864
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Genetics
PLoS Genetics, Vol 9, Iss 10, p e1003864 (2013)
PLoS Genetics 9(10), e1003864 (2013). doi:10.1371/journal.pgen.1003864
PLoS Genetics, 9(10):e1003864. Public Library of Science
PLOS Genetics
Repositório Institucional da UNIFESP
Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
PLOS GENETICS
PLoS Genetics (print), 9(10). Public Library of Science
PLoS genetics, 9(10). Public Library of Science
Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686a4341f35ee18e526d61a0482fccdd
https://research.vumc.nl/en/publications/c9466bc4-c7d4-4632-bd50-3178b290bbeb

Deciphering the genetic structure of the Quebec founder population using genealogies.

Autor: Gagnon L; Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada.; Centre Intersectoriel en Santé Durable (CISD), Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada., Moreau C; Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada.; Centre Intersectoriel en Santé Durable (CISD), Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada., Laprise C; Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada.; Centre Intersectoriel en Santé Durable (CISD), Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada.; Centre Intégré Universitaire en Santé et Services Sociaux du Saguenay-Lac-Saint-Jean, Saguenay, Québec, G7H 7K9, Canada., Vézina H; Centre Intersectoriel en Santé Durable (CISD), Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada.; Département des Sciences Humaines et Sociales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada.; Projet BALSAC, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada., Girard SL; Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. simon2_girard@uqac.ca.; Centre Intersectoriel en Santé Durable (CISD), Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. simon2_girard@uqac.ca.; Centre de Recherche CERVO, Université Laval, Québec, Québec, G1V 0A6, Canada. simon2_girard@uqac.ca.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2024 Jan; Vol. 32 (1), pp. 91-97. Date of Electronic Publication: 2023 Apr 04.

Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits.

Autor: Bahda M; Department of Mathematics and Statistic, Laval University, Québec, QC G1V 0A6, Canada.; CERVO Brain Research Centre, Québec, QC G1E 1T2, Canada., Ricard J; CERVO Brain Research Centre, Québec, QC G1E 1T2, Canada., Girard SL; CERVO Brain Research Centre, Québec, QC G1E 1T2, Canada.; Department of Fundamental Sciences, University of Quebec in Chicoutimi, Chicoutimi, QC G7H 2B1, Canada., Maziade M; CERVO Brain Research Centre, Québec, QC G1E 1T2, Canada.; Department of Psychiatry and Neurosciences, Laval University, Québec, QC G1V 0A6, Canada., Isabelle M; CERVO Brain Research Centre, Québec, QC G1E 1T2, Canada.; Department of Economics, Laval University, Québec, QC G1V 0A6, Canada., Bureau A; CERVO Brain Research Centre, Québec, QC G1E 1T2, Canada.; Department of Social and Preventive Medicine, Laval University, Québec, QC G1V 0A6, Canada.

Publikováno v: HGG advances [HGG Adv] 2023 May 20; Vol. 4 (3), pp. 100209. Date of Electronic Publication: 2023 May 20 (Print Publication: 2023).

Association of Essential Tremor With Novel Risk Loci: A Genome-Wide Association Study and Meta-analysis.

Autor: Liao C; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Castonguay CE; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Heilbron K; 23andMe, Inc, Sunnyvale, California., Vuokila V; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Medeiros M; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Houle G; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Akçimen F; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Ross JP; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Catoire H; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Diez-Fairen M; Fundació Docència i Recerca Mútua Terrassa, University Hospital Mútua de Terrassa, Terrassa, Barcelona, Spain.; Movement Disorders Unit, Department of Neurology, University Hospital Mútua de Terrassa, Terrassa, Barcelona, Spain., Kang J; Division of Genetic Medicine, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee., Mueller SH; Institute of Health Informatics, University College London, London, United Kingdom., Girard SL; Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Hopfner F; Department of Neurology, Hannover Medical School, Hannover, Germany., Lorenz D; University Children's Hospital, University of Würzburg, Wurzburg, Germany., Clark LN; Department of Pathology and Cell Biology, Taub Institute, Columbia University, New York, New York., Soto-Beasley AI; Department of Neurology, Mayo Clinic Florida, Jacksonville., Klebe S; Department of Neurology, University Hospital Würzburg, Wurzburg, Germany.; Department of Neurology, University Hospital Essen, Essen, Germany., Hallett M; National Institute of Neurological Disorders and Stroke Intramural Research Program, National Institutes of Health, Bethesda, Maryland., Wszolek ZK; Department of Neurology, Mayo Clinic Florida, Jacksonville., Pendziwiat M; Institute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.; Department of Neuropediatrics, University Medical Center Schleswig-Holstein, University of Kiel, Kiel, Germany., Lorenzo-Betancor O; Veterans Affairs Puget Sound Health Care System, Seattle, Washington.; Department of Neurology, University of Washington School of Medicine, Seattle., Seppi K; Department of Neurology, Innsbruck Medical University, Innsbruck, Austria., Berg D; Department of Neurology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany., Vilariño-Güell C; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Postuma RB; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Bernard G; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Division of Pediatric Neurology, Departments of Pediatrics, Neurology and Neurosurgery, Montreal Children's Hospital, Montreal, Quebec, Canada.; Child Health and Human Development Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.; Division of Medical Genetics, Department of Specialized Medicine, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada., Dupré N; Faculté de Médecine, Université Laval, Centre Hospitalier Universitaire de Québec (l'Enfant-Jésus), Quebec, Canada., Jankovic J; Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas., Testa CM; Parkinson's and Movement Disorders Center, Department of Neurology, Virginia Commonwealth University, Richmond., Ross OA; Departments of Neuroscience and Clinical Genomics, Mayo Clinic Florida, Jacksonville., Arzberger T; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany., Chouinard S; Unité des troubles du mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada., Louis ED; Department of Neurology, The University of Texas Southwestern Medical Center, Dallas., Mandich P; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health (DINOGMI), University of Genoa, Genova, Italy.; Istituto di Ricovero e Cura a Carattere Scientifico Policlinico, San Martino, Genova, Italy., Vitale C; Department of Motor Sciences and Wellness, University Parthenope, Naples, Italy., Barone P; Center for Neurodegenerative Disease (CEMAND), Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Salerno, Italy., García-Martín E; University Institute of Molecular Pathology Biomarkers, UNEx, ARADyAL Instituto de Salud Carlos III, Caceres, Spain., Alonso-Navarro H; Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain., Agúndez JAG; University Institute of Molecular Pathology Biomarkers, UNEx, ARADyAL Instituto de Salud Carlos III, Caceres, Spain., Jiménez-Jiménez FJ; Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain., Pastor P; Fundació Docència i Recerca Mútua Terrassa, University Hospital Mútua de Terrassa, Terrassa, Barcelona, Spain., Rajput A; University of Saskatchewan, Saskatoon Health Authority, Saskatoon, Saskatchewan, Canada., Deuschl G; Department of Neurology, University Medical Center Schleswig Holstein, University of Kiel, Kiel, Germany., Kuhlenbaümer G; Department of Neurology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany., Meijer IA; Department of Neuroscience and Pediatrics, Université de Montréal, Montreal, Quebec, Canada., Dion PA; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Rouleau GA; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

Publikováno v: JAMA neurology [JAMA Neurol] 2022 Feb 01; Vol. 79 (2), pp. 185-193.

Testing association of rare genetic variants with resistance to three common antiseizure medications.

Autor: Wolking S; Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Department of Neurosciences, Research Center of the University of Montreal Hospital Center (CRCHUM), University of Montreal, Montreal, Canada., Moreau C; Department of Applied Sciences, University of Quebec in Chicoutimi, Saguenay, Canada., Nies AT; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., Schaeffeler E; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., McCormack M; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Auce P; Walton Centre NHS Foundation Trust, Liverpool, UK., Avbersek A; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, London, UK., Becker F; Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Krenn M; Department of Neurology, Medical University of Vienna, Vienna, Austria., Møller RS; Danish Epilepsy Centre - Filadelfia, Dianalund, Denmark.; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Nikanorova M; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark., Weber YG; Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Department of Epileptology and Neurology, University of Aachen, Aachen, Germany., Weckhuysen S; Neurogenetics Group, VIB-UAntwerp, Center for Molecular Neurology, Antwerp, Belgium.; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.; Department of Neurology, Antwerp University Hospital, Antwerp, Belgium., Cavalleri GL; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Division of Brain Sciences, Imperial College Faculty of Medicine, London, UK., Delanty N; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Division of Neurology, Beaumont Hospital, Dublin, Ireland.; The FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland., Depondt C; Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium., Johnson MR; Division of Brain Sciences, Imperial College Faculty of Medicine, London, UK., Koeleman BPC; Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands., Kunz WS; Institute of Experimental Epileptology and Cognition Research and Department of Epileptology, University of Bonn, Bonn, Germany., Marson AG; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK., Sander JW; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, London, UK.; Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands., Sills GJ; Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK., Striano P; IRCCS 'G. Gaslini' Institute, Genova, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy., Zara F; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy., Zimprich F; Department of Neurology, Medical University of Vienna, Vienna, Austria., Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany.; Department of Clinical Pharmacology, Pharmacy and Biochemistry, University Tübingen, Tübingen, Germany., Krause R; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Sisodiya SM; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, London, UK., Cossette P; Department of Neurosciences, Research Center of the University of Montreal Hospital Center (CRCHUM), University of Montreal, Montreal, Canada., Girard SL; Department of Applied Sciences, University of Quebec in Chicoutimi, Saguenay, Canada., Lerche H; Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Publikováno v: Epilepsia [Epilepsia] 2020 Apr; Vol. 61 (4), pp. 657-666. Date of Electronic Publication: 2020 Mar 06.