Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Giovanni Sorba"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1335-1351 (2021)
Organic chemistry honors Icilio Guareschi (1847–1918) with three eponymic reactions, the best known ones being the Guareschi synthesis of pyridones and the Guareschi–Lustgarten reaction. A third Guareschi reaction, the so-called “Guareschi 1897
Externí odkaz:
https://doaj.org/article/3ae24eaa3a7a4817825309f4a0fe842d
Autor:
Ubaldina Galli, Elisa Ciraolo, Alberto Massarotti, Jean Piero Margaria, Giovanni Sorba, Emilio Hirsch, Gian Cesare Tron
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 17275-17287 (2015)
A novel series of 4-aryl-3-cyano-2-(3-hydroxyphenyl)-6-morpholino-pyridines have been designed as potential phosphatidylinositol-3-kinase (PI3K) inhibitors. The compounds have been synthesized using the Guareschi reaction to prepare the key 4-aryl-3-
Externí odkaz:
https://doaj.org/article/1dfbdea40a17481daa4a4048c493dcaf
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1335-1351 (2021)
Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry
Organic chemistry honors Icilio Guareschi (1847–1918) with three eponymic reactions, the best known ones being the Guareschi synthesis of pyridones and the Guareschi–Lustgarten reaction. A third Guareschi reaction, the so-called “Guareschi 1897
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d33c7646f757865e123b5d34f18e0dd
https://doi.org/10.3762/bjoc.17.93
https://doi.org/10.3762/bjoc.17.93
Autor:
Fabio Seiti, Franco Pattarino, Armando A. Genazzani, Asia Fernández-Carvajal, Isabel Devesa, Cristina Travelli, Silvio Aprile, Marta Serafini, Tracey Pirali, Laura Butron, Giorgio Grosa, Alessia Griglio, Giovanni Sorba, Antonio Ferrer-Montiel, Sara González-Rodríguez
Publikováno v:
Journal of Medicinal Chemistry. 61:4436-4455
Despite being an old molecule, capsaicin is still a hot topic in the scientific community, and the development of new capsaicinoids is a promising pharmacological approach in the management of skin disorders related to inflammation and pruritus. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ad69208858b1630be2787cc127e880
https://doi.org/10.1021/acs.jmedchem.8b00109
https://doi.org/10.1021/acs.jmedchem.8b00109
Autor:
Alice Bianchi, Alessia Griglio, Alberto Massarotti, Giovanni Sorba, Silvia Fallarini, Marta Serafini, Tracey Pirali, Enza Torre, Giulia Coda Zabetta, Roberta Schmid
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:651-657
Indoleamine 2,3-dioxygenase plays a crucial role in immune tolerance and has emerged as an attractive target for cancer immunotherapy. In this study, the Passerini and Ugi multicomponent reactions have been employed to assemble a small library of imi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beef471b6e9ce2c4ef3fb08aa3fd5010
https://doi.org/10.1016/j.bmcl.2018.01.032
https://doi.org/10.1016/j.bmcl.2018.01.032
Autor:
Alberto Massarotti, Tracey Pirali, Silvio Aprile, Clarissa Landoni, Roger L. Williams, Valentina Mercalli, Alessia Griglio, Rangel L. Silva, Carlo Cosimo Campa, Jean Piero Margaria, Alex Berndt, Elisa Ciraolo, Emilio Hirsch, Marta Serafini, Giovanni Sorba, Giorgio Grosa, Gian Cesare Tron
Publikováno v:
'ChemMedChem ', vol: 12, pages: 1542-1554 (2017)
Chemmedchem
Chemmedchem
Activation of the phosphoinositide 3‐kinase (PI3K) pathway is a key signaling event in cancer, inflammation, and other proliferative diseases. PI3K inhibitors are already approved for some specific clinical indications, but their systemic on‐targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8362b87328db7cdcf3eba819644e7
https://doi.org/10.1002/cmdc.201700340
https://doi.org/10.1002/cmdc.201700340
Autor:
R. Bergo, Alberto Massarotti, B. Giannelli, Silvia Fallarini, A. Brunco, Tracey Pirali, Giovanni Sorba, G. Coda Zabetta, S. Giovarruscio, Grazia Lombardi, Alessandro Gesù
Publikováno v:
MedChemComm. 7:409-419
Indoleamine 2,3-dioxygenase is involved in pathological immune escape and has recently become an attractive target for anti-cancer therapy. 4-Phenylimidazole (4-PI) provides a promising starting point for the development of IDO1 inhibitors. With the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0c992a00d7dbf1efc4f7fb68b52771
https://doi.org/10.1039/c5md00317b
https://doi.org/10.1039/c5md00317b
Autor:
Cristina Travelli, Alberto Massarotti, Ubaldina Galli, Armando A. Genazzani, Giorgio Grosa, Giovanni Sorba, Elena Arrigoni, Simone Torretta, Gian Cesare Tron, Silvio Aprile, Pier Luigi Canonico
Publikováno v:
Journal of Medicinal Chemistry. 58:1345-1357
In the present manuscript, starting from the 1,4-benzodiazepin-2-one nucleus, a privileged structure in medicinal chemistry, we have synthesized a novel class of cis-locked combretastatins named combreatabenzodiazepines. They show similar cytotoxic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434a190c72664488cef0e68787089fa0
https://doi.org/10.1021/jm5016389
https://doi.org/10.1021/jm5016389
Autor:
P. L. Canonico, Antonio Caldarelli, Giovanni Sorba, Mariateresa Giustiniano, Ettore Novellino, Valentina Bevilacqua, Tracey Pirali, Gian Cesare Tron, Ornella Mesenzani, Alberto Massarotti, Armando A. Genazzani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:764-768
In the chalcone scaffold, it is thought that the double bond is an important structural linker but it is likely not essential for the interaction with tubulin. Yet, it may be a potential site of metabolic degradation and interaction with biological n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef08647d49c3513974e6dc3ed27d447
https://doi.org/10.1016/j.bmcl.2010.11.113
https://doi.org/10.1016/j.bmcl.2010.11.113
Autor:
Cristina Travelli, Silvio Aprile, Salvatore Terrazzino, Armando A. Genazzani, Alberto Massarotti, Salvatore Cuzzocrea, Daniela Impellizzeri, Gohar Fakhfouri, Roberta Fusco, Reza Rahimian, Giorgio Stortini, Rosanna Di Paola, Mattia Bertolotti, Giuseppe Orsomando, Erika Del Grosso, Maria Pia Troiani, Giorgio Grosa, Floriana Malagnino, Ambra A. Grolla, Ubaldina Galli, Federica Rogati, Giovanni Sorba, Valentina Mercalli, Gian Cesare Tron, Pier Luigi Canonico, Maria Alessandra Alisi
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme involved in the recycling of nicotinamide to maintain adequate NAD levels inside the cells. It has been postulated to be a pharmacological target, as it is overexpressed in cancer cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c21ddd282d14925480550980cd06ad7
http://hdl.handle.net/11570/3121688
http://hdl.handle.net/11570/3121688
