Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Giovanni Quarato"'
Autor:
Diego A. Rodriguez, Bart Tummers, Jeremy J.P. Shaw, Giovanni Quarato, Ricardo Weinlich, James Cripps, Patrick Fitzgerald, Laura J. Janke, Stephane Pelletier, Jeremy Chase Crawford, Douglas R. Green
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114335- (2024)
Summary: Perturbation of the apoptosis and necroptosis pathways critically influences embryogenesis. Receptor-associated protein kinase-1 (RIPK1) interacts with Fas-associated via death domain (FADD)-caspase-8-cellular Flice-like inhibitory protein l
Externí odkaz:
https://doaj.org/article/1e0db83b24f847f8b7f218099ee40210
Autor:
Flavia A. Graca, Mamta Rai, Liam C. Hunt, Anna Stephan, Yong-Dong Wang, Brittney Gordon, Ruishan Wang, Giovanni Quarato, Beisi Xu, Yiping Fan, Myriam Labelle, Fabio Demontis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Myofiber atrophy occurs in many diseases but the mechanisms responsible for myofiber size determination are incompletely understood. Here, the authors show that the muscle-secreted factor Fibcd1 is necessary to maintain myofiber size and mitigates my
Externí odkaz:
https://doaj.org/article/5cbdb4d779ef41379fe96cd79ef579e7
Autor:
Susana L. Orozco, Brian P. Daniels, Nader Yatim, Michelle N. Messmer, Giovanni Quarato, Haiyin Chen-Harris, Sean P. Cullen, Annelise G. Snyder, Pooja Ralli-Jain, Sharon Frase, Stephen W.G. Tait, Douglas R. Green, Matthew L. Albert, Andrew Oberst
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2275-2287.e5 (2019)
Summary: Necroptosis is a form of programmed cell death that is defined by activation of the kinase RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 activation can also promote immune responses via production of cytokin
Externí odkaz:
https://doaj.org/article/7ffc260e505644a99f8c4f409cad4f57
Autor:
Stephen W.G. Tait, Andrew Oberst, Giovanni Quarato, Sandra Milasta, Martina Haller, Ruoning Wang, Maria Karvela, Gabriel Ichim, Nader Yatim, Matthew L. Albert, Grahame Kidd, Randall Wakefield, Sharon Frase, Stefan Krautwald, Andreas Linkermann, Douglas R. Green
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 878-885 (2013)
Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation of receptor interacting protein kinase-3 (RIPK3). Several reports have implicated mitochondria and mitochondrial reactive oxygen species (ROS) generation as effe
Externí odkaz:
https://doaj.org/article/3bac1bef9e604f5e88b84218c1ad4f99
Autor:
Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic, Douglas R. Green
Publikováno v:
Cell Death Differ
The ability of mitochondria to buffer a rapid rise in cytosolic Ca(2+) is a hallmark of proper cell homeostasis. Here, we employed m-3M3FBS, a putative phospholipase C (PLC) agonist, to explore the relationships between intracellular Ca(2+) imbalance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab54d66980d55325eacebf630dd38416
https://doi.org/10.1038/s41418-022-01025-9
https://doi.org/10.1038/s41418-022-01025-9
Autor:
Giovanni Quarato, Luigi Mari, Nicholas J. Barrows, Mao Yang, Sebastian Ruehl, Mark J. Chen, Cliff S. Guy, Jonathan Low, Taosheng Chen, Douglas R. Green
Publikováno v:
Science Advances. 9
Degradation of defective mitochondria is an essential process to maintain cellular homeostasis and it is strictly regulated by the ubiquitin-proteasome system (UPS) and lysosomal activities. Here, using genome-wide CRISPR and small interference RNA s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccac7f95984ff338aaf0a3da46df9f00
https://doi.org/10.1126/sciadv.adg8156
https://doi.org/10.1126/sciadv.adg8156
Autor:
Diego A. Rodriguez, Giovanni Quarato, Swantje Liedmann, Bart Tummers, Ting Zhang, Cliff Guy, Jeremy Chase Crawford, Gustavo Palacios, Stephane Pelletier, Halime Kalkavan, Jeremy J. P. Shaw, Patrick Fitzgerald, Mark J. Chen, Siddharth Balachandran, Douglas R. Green
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The absence of Caspase-8 or its adapter, Fas-associated death domain (FADD), results in activation of receptor interacting protein kinase-3 (RIPK3)- and mixed-lineage kinase-like (MLKL)–dependent necroptosis in vivo. Here, we show that spontaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402494caac5e892448e01270d75f3b2b
https://doi.org/10.1073/pnas.2207240119
https://doi.org/10.1073/pnas.2207240119
Autor:
Claudio Hetz, Alvaro Glavic, Philippe Pihán, Amaury Pupo, Suvi Saarnio, Giovanni Quarato, Sandra Sofía Edwards-Jorquera, Diego A. Rodriguez, Daniela De Giorgis, Guido Kroemer, Oliver Kepp, Nicolas Demaurex, Karen Castillo, Eija Jokitalo, Janina Borgonovo, Sabrina Forveille, Amado Carreras-Sureda, Fernanda Lourido, Miguel L. Concha, Paula Nunes-Hasler, Fernanda Lisbona, Douglas R. Green, Anthony Letai, Hery Urra, Alfredo Sagredo, Allan Sauvat, Ramon Latorre, Helena Vihinen
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (46), ⟨10.1126/sciadv.abe5469⟩
Science Advances, 2021, 7 (46), ⟨10.1126/sciadv.abe5469⟩
Science advances, Vol. 7, No 46 (2021) P. eabe5469
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (46), ⟨10.1126/sciadv.abe5469⟩
Science Advances, 2021, 7 (46), ⟨10.1126/sciadv.abe5469⟩
Science advances, Vol. 7, No 46 (2021) P. eabe5469
Description
RECS1, a member of the TMBIM family, triggers lysosomal membrane permeabilization in cells undergoing lysosomal stress.
Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have i
RECS1, a member of the TMBIM family, triggers lysosomal membrane permeabilization in cells undergoing lysosomal stress.
Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8206126f35066a19b6c7861afb35003f
https://hal.sorbonne-universite.fr/hal-03428914/file/sciadv.abe5469.pdf
https://hal.sorbonne-universite.fr/hal-03428914/file/sciadv.abe5469.pdf
Autor:
Giovanni, Quarato, Fabien, Llambi, Cliff S, Guy, Jaeki, Min, Marisa, Actis, Huan, Sun, Shilpa, Narina, Shondra M, Pruett-Miller, Junmin, Peng, Zoran, Rankovic, Douglas R, Green
Publikováno v:
Cell Death Differ
The ability of mitochondria to buffer a rapid rise in cytosolic Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05c9cc8d2035082a50a1ac27b1289012
https://pubmed.ncbi.nlm.nih.gov/35831625
https://pubmed.ncbi.nlm.nih.gov/35831625
Autor:
Weihong Wang, Shaoxian Wu, Zhanpeng Cen, Yixin Zhang, Yuang Chen, Yixian Huang, Anthony R. Cillo, Joshua S. Prokopec, Giovanni Quarato, Dario A.A. Vignali, Jacob Stewart-Ornstein, Song Li, Binfeng Lu, Yi-Nan Gong
Publikováno v:
Cell reports. 41(5)
In "healthy" tumor cells, phosphatidylserine (PS) is predominately localized in the inner plasma membrane leaflet. During apoptosis, PS relocates to the outer leaflet. Herein, we established PS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307da19ca19124287d86eb8cd32350d2
https://pubmed.ncbi.nlm.nih.gov/36323258
https://pubmed.ncbi.nlm.nih.gov/36323258