Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Giovanni Magnani"'
Autor:
Sabrina Ghetti, Matteo Burigotto, Alessia Mattivi, Giovanni Magnani, Antonio Casini, Andrea Bianchi, Anna Cereseto, Luca L. Fava
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100407- (2021)
Summary: hTERT-RPE1 cells are genetically stable near diploid cells widely used to model cell division, DNA repair, or ciliogenesis in a non-transformed context. However, poor transfectability and limited homology-directed repair capacity hamper thei
Externí odkaz:
https://doaj.org/article/294fe2aa56894733919f4f9a45f9d3c4
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Svenja Wöhrle, Larissa Fischer, Anna Kostina, Stephan Flemming, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian N. Parker, Andreas Boettcher, Christopher J. Farady, Rebecca Kesselring, Christopher Berlin, Rolf Backofen, Marta Rodriguez-Franco, Clemens Kreutz, Marco Prinz, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Publikováno v:
Science Signaling. 16
Inflammasomes are intracellular protein complexes that promote an inflammatory host defense in response to pathogens and damaged or neoplastic tissues and are implicated in inflammatory disorders and therapeutic-induced toxicity. We investigated the
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Anna Kostina, Svenja Wöhrle, Stephan Flemming, Larissa Fischer, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian Parker, Andreas Boettcher, Christopher J. Farady, Rolf Backofen, Marta Rodriguez-Franco, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Inflammasomes are intracellular protein complexes that control proteolytic maturation and secretion of inflammatory interleukin-1 (IL-1) family cytokines and are thus important in host defense. While some inflammasomes are activated simply by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91918a639a74468417a76d5d58c4b680
https://doi.org/10.1101/2022.02.19.480941
https://doi.org/10.1101/2022.02.19.480941
Autor:
Anna Cereseto, Matteo Burigotto, Giovanni Magnani, Antonio Casini, Sabrina Ghetti, Luca L. Fava, Alessia Mattivi, Andrea Bianchi
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 2, Pp 100407-(2021)
STAR Protocols, Vol 2, Iss 2, Pp 100407-(2021)
Summary hTERT-RPE1 cells are genetically stable near diploid cells widely used to model cell division, DNA repair, or ciliogenesis in a non-transformed context. However, poor transfectability and limited homology-directed repair capacity hamper their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf1bafbf84a3959d1e3550e22831d04
https://www.sciencedirect.com/science/article/pii/S2666166721001143?via=ihub
https://www.sciencedirect.com/science/article/pii/S2666166721001143?via=ihub
Autor:
Stefano Maffini, Giovanni Magnani, Alessia Mattivi, Chiara Valentini, Matteo Burigotto, Alexander Schmidt, Andreas Villunger, Massimo Pizzato, Daniele Migliorati, Luca L. Fava, Martin Offterdinger, Michela Roccuzzo
Publikováno v:
The EMBO Journal
Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07afb911a22bfbe2cc03a5dd6c48a921
https://www.embopress.org/doi/full/10.15252/embj.2020104844
https://www.embopress.org/doi/full/10.15252/embj.2020104844
Autor:
Jürgen Ruland, Thomas Engleitner, Enkhtsetseg Munkhbaatar, Stephanie Rott, Johanna Kauschinger, Michael Heuser, Giovanni Magnani, Philipp J. Jost, Mathias Heikenwalder, Karl Sotlar, Ulrike Höckendorf, Julia Slotta-Huspenina, Hans Kreipe, Monica Yabal, Tobias Herold, Olaf Groß, Karsten Spiekermann, Christian Peschel, Wilko Weichert, Roland Rad, Stefanie Jilg, Florian Reisinger
Publikováno v:
Cancer Cell 30, 75-91 (2016)
Since acute myeloid leukemia (AML) is characterized by the blockade of hematopoietic differentiation and cell death, we interrogated RIPK3 signaling in AML development. Genetic loss of Ripk3 converted murine FLT3-ITD-driven myeloproliferation into an
Autor:
Avril A. B. Robertson, Lara Hartjes, Oliver Gorka, Stephan Fromm, Kate Schroder, Christina J. Groß, Katharina S. Schneider, Giovanni Magnani, Claudia Traidl-Hoffmann, Hexin Shi, Mark E. Cooper, Bernhard Kuster, Guillaume Médard, Michael Schuster, Petr Broz, Jürgen Ruland, Fabiana Perocchi, Paul-Albert Koenig, Sabine Schneider, Tamara Cikovic, Bruce Beutler, Jennifer Wettmarshausen, Joachim Smollich, Ritu Mishra, Marc Schmidt-Supprian, Daniela Dittlein, Olaf Groß
Publikováno v:
Immunity 45, 761-773 (2016)
Immunity
Immunity
Imiquimod is a small-molecule ligand of Toll-like receptor-7 (TLR7) that is licensed for the treatment of viral infections and cancers of the skin. Imiquimod has TLR7-independent activities that are mechanistically unexplained, including NLRP3 inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800192c21ccf3f4d7f613bc6f8b6f185
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49726
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49726
Autor:
Christina J, Groß, Ritu, Mishra, Katharina S, Schneider, Guillaume, Médard, Jennifer, Wettmarshausen, Daniela C, Dittlein, Hexin, Shi, Oliver, Gorka, Paul-Albert, Koenig, Stephan, Fromm, Giovanni, Magnani, Tamara, Ćiković, Lara, Hartjes, Joachim, Smollich, Avril A B, Robertson, Matthew A, Cooper, Marc, Schmidt-Supprian, Michael, Schuster, Kate, Schroder, Petr, Broz, Claudia, Traidl-Hoffmann, Bruce, Beutler, Bernhard, Kuster, Jürgen, Ruland, Sabine, Schneider, Fabiana, Perocchi, Olaf, Groß
Publikováno v:
Immunity. 45(4)
Imiquimod is a small-molecule ligand of Toll-like receptor-7 (TLR7) that is licensed for the treatment of viral infections and cancers of the skin. Imiquimod has TLR7-independent activities that are mechanistically unexplained, including NLRP3 inflam
Publikováno v:
The Biochemical journal. 455(2)
Enzymes that produce or recycle folates are the targets of widely used antimalarial drugs. Despite the interest in the folate metabolism of Plasmodium falciparum, the molecular identification of ADCL (aminodeoxychorismate lyase), which synthesizes th