Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Giovanni Liberi"'
Autor:
Giorgio Minotti, Emanuela Salvatorelli, Pierantonio Menna, Luca Gianni, Simone Guarnieri, Maria A. Mariggiò, Giovanni Liberi, Alvaro Mordente, Antonio M. Calafiore
Publikováno v:
Journal of Biological Chemistry. 281:10990-11001
One-electron quinone reduction and two-electron carbonyl reduction convert the anticancer anthracycline doxorubicin to reactive oxygen species (ROS) or a secondary alcohol metabolite that contributes to inducing a severe form of cardiotoxicity. The c
Autor:
Giorgio Minotti, Antonio M. Calafiore, Pierantonio Menna, Luca Gianni, Giovanni Liberi, Sabrina Cascegna, Emanuela Salvatorelli
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 318(1)
Antitumor therapy with the anthracycline doxorubicin is limited by a dose-related cardiotoxicity that is aggravated by a concomitant administration of the taxane paclitaxel. Previous limited studies with isolated human heart cytosol showed that pacli
Autor:
Emanuela, Salvatorelli, Simone, Guarnieri, Pierantonio, Menna, Giovanni, Liberi, Antonio M, Calafiore, Maria A, Mariggiò, Alvaro, Mordente, Luca, Gianni, Giorgio, Minotti
One-electron quinone reduction and two-electron carbonyl reduction convert the anticancer anthracycline doxorubicin to reactive oxygen species (ROS) or a secondary alcohol metabolite that contributes to inducing a severe form of cardiotoxicity. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5fba7c32a7e4f308d0138a4300907822
http://hdl.handle.net/10807/9774
http://hdl.handle.net/10807/9774
Autor:
Giorgio Minotti, Rossella Giampietro, Giovanni Liberi, Giovanni Teodori, Pierantonio Menna, Emanuela Salvatorelli, and Antonio M. Calafiore
Publikováno v:
Chemical research in toxicology. 15(9)
Lipid peroxidation has been proposed to mediate cardiotoxicity induced by doxorubicin (DOX) and other anticancer anthracyclines; however, there have been reports showing that DOX can also inhibit lipid peroxidation. Here we characterized the effects
Autor:
and Stefano Manzini, Fabio Animati, Antonella Saponiero, Giovanni Liberi, Antonio M. Calafiore, Gabriele Di Giammarco, Amalia Cipollone, Giorgio Minotti, Carlo Alberto Maggi, Pierantonio Menna, Sabrina Licata
Publikováno v:
Chemical research in toxicology. 13(12)
Secondary alcohol metabolites have been proposed to mediate chronic cardiotoxicity induced by doxorubicin (DOX) and other anticancer anthracyclines. In this study, NADPH-supplemented human cardiac cytosol was found to reduce the carbonyl group in the
Autor:
Giovanni Liberi, Antonio M. Calafiore, Cesare Mancuso, Alvaro Mordente, Andrea Frustaci, Giorgio Minotti, Stefano Angelo Santini, N Gentiloni
Publikováno v:
Scopus-Elsevier
Anticancer therapy with doxorubicin (DOX) and other quinone anthracyclines is limited by severe cardiotoxicity, reportedly because semiquinone metabolites delocalize Fe(II) from ferritin and generate hydrogen peroxide, thereby promoting hydroxyl radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a76382a18e545d5ecb6e03e45c18f2
http://hdl.handle.net/10807/9396
http://hdl.handle.net/10807/9396
Autor:
Giorgio Minotti, Alvaro Mordente, Stefania Recalcati, Cesare Mancuso, Gaetano Cairo, Antonio M. Calafiore, Paolo Preziosi, Giovanni Liberi
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
Anticancer therapy with doxorubicin (DOX) is limited by severe cardiotoxicity, presumably reflecting the intramyocardial formation of drug metabolites that alter cell constituents and functions. In a previous study, we showed that NADPH-supplemented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f566ec66c3496645ceb660c03ef574cc
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031897342&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0031897342&partnerID=MN8TOARS