Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Giovanni C. Forcina"'
Autor:
Fraser D. Johnson, John Ferrarone, Alvin Liu, Christina Brandstädter, Ravi Munuganti, Dylan A. Farnsworth, Daniel Lu, Jennifer Luu, Tianna Sihota, Sophie Jansen, Amy Nagelberg, Rocky Shi, Giovanni C. Forcina, Xu Zhang, Grace S.W. Cheng, Sandra E. Spencer Miko, Georgia de Rappard-Yuswack, Poul H. Sorensen, Scott J. Dixon, Udayan Guha, Katja Becker, Hakim Djaballah, Romel Somwar, Harold Varmus, Gregg B. Morin, William W. Lockwood
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110343- (2022)
Summary: Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their targets and mechanisms of action. Here, we show that a compound termed LCS3, which s
Externí odkaz:
https://doaj.org/article/777c0ebba6e744a58fb41d6fac2350cb
Autor:
Kayvon Pedram, D. Judy Shon, Gabrielle S. Tender, Natalia R. Mantuano, Jason J. Northey, Kevin J. Metcalf, Simon P. Wisnovsky, Nicholas M. Riley, Giovanni C. Forcina, Stacy A. Malaker, Angel Kuo, Benson M. George, Caitlyn L. Miller, Kerriann M. Casey, José G. Vilches-Moure, Valerie M. Weaver, Heinz Laübli, Carolyn R. Bertozzi
Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of substrates that can be selectively degraded, we designed degraders which are dependent on both peptide sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eae7cde10003a5bd8961704a25b061e
https://doi.org/10.1101/2022.05.20.492748
https://doi.org/10.1101/2022.05.20.492748
Autor:
David A. Armenta, Megan Conlon, Alexis Kahanu, Alex Wells, Carson D. Poltorack, Melodie Mallais, Derek A. Pratt, Leslie Magtanong, Giovanni C. Forcina, Marcos A. Perez, Jennifer L. Watts, Scott J. Dixon
Publikováno v:
Nature chemical biology
Cell death can be executed by regulated apoptotic and non-apoptotic pathways, including the iron-dependent process of ferroptosis. Small molecules are essential tools for studying the regulation of cell death. Using time-lapse imaging, and a library
Autor:
Giovanni C. Forcina, Lauren Pope, Magdalena Murray, Wentao Dong, Monther Abu-Remaileh, Carolyn R. Bertozzi, Scott J. Dixon
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(11)
Significance Ferroptosis is an oxidative form of cell death whose biochemical regulation remains incompletely understood. Cap’n’collar (CNC) transcription factors including nuclear factor erythroid-2–related factor 1 (NFE2L1/NRF1) and NFE2L2/NR
Autor:
Giovanni C. Forcina, Magdalena Murray, Carolyn R. Bertozzi, Monther Abu-Remaileh, Lauren E Pope, Wentao Dong, Scott J. Dixon
Ferroptosis is an oxidative form of non-apoptotic cell death whose transcriptional regulation is poorly understood. Cap’n’collar (CNC) transcription factors including Nuclear Factor Erythroid-2 Related Factor 1 (NFE2L1/NRF1) and NFE2L2 (NRF2) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfaa211abe626f3c09015db071c3bd6e
https://doi.org/10.1101/2021.10.12.463965
https://doi.org/10.1101/2021.10.12.463965
Autor:
Katja Becker, Fraser Johnson, Grace Cheng, William W. Lockwood, Sandra E. Spencer Miko, Scott J. Dixon, Hakim Djaballah, Poul H. Sorenesen, Romel Somwar, Giovanni C. Forcina, Sophie Jansen, John Ferrarone, Dylan Fansworth, Georgia de Rappard-Yuswack, Tianna Sihota, Alvin Liu, Jennifer Luu, Udayan Guha, Rocky Shi, Gregg B. Morin, Christina Brandstädter, Ravi Shashi Nayana Munuganti, Harold E. Varmus, Daniel Lu, Amy Nagelberg, Xu Zhang
High-throughput phenotype-based screening of large libraries of novel compounds without known targets can identify small molecules that elicit a desired cellular response, but additional approaches are required to find and characterize their targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48adee1903168cea86353def315a9cf9
https://doi.org/10.1101/2021.06.28.450088
https://doi.org/10.1101/2021.06.28.450088
SUMMARYIndividual cancer cells within a population can exhibit substantial phenotypic heterogeneity such that exposure to a lethal agent will kill only a fraction of cells at a given time. Whether common molecular mechanisms govern this fractional ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0011f182a5708ab5371ec859661aa443
Autor:
Steven J.M. Jones, J. An, Amy Nagelberg, Katja Becker, A. Prudova, Scott J. Dixon, Alvin Liu, D. Farnsworth, Harold E. Varmus, Christina Brandstädter, Sophie Jansen, Gregg B. Morin, Poul H. Sorensen, Fraser Johnson, William W. Lockwood, Jennifer Luu, Giovanni C. Forcina, T. Sihota, Daniel Lu, Romel Somwar
Publikováno v:
Journal of Thoracic Oncology. 15:S31-S32
Autor:
Giovanni C. Forcina, Scott J. Dixon
Publikováno v:
Proteomics. 19(18)
Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids and other macromolecules. Oxidation of cholesterol and phospholipids containing polyunsaturated fatty acyl chains can lead to lipid peroxidation, membrane damage
Autor:
Miroslav Kolařík, Ivana Kelnarová, Ki Woong Kang, Milada Chudíčková, Demetra Skaltsas, Alena Nováková, Alena Kubátová, Jeffrey J. Shaw, Giovanni C. Forcina, Romina Gazis, Scott A. Strobel, Carolina E. Portero, Daniel Spakowicz, Alexandra Narváez-Trujillo
Publikováno v:
Plant Systematics and Evolution. 303:35-50
Biatriospora (Ascomycota: Pleosporales, Biatriosporaceae) is a genus with unexplored diversity and poorly known ecology. This work expands the Biatriospora taxonomic and ecological concept by describing four new species found as endophytes of woody p