Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Giovanni Bottegoni"'
Autor:
Mariarosaria Ferraro, Matteo Masetti, Maurizio Recanatini, Andrea Cavalli, Giovanni Bottegoni
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0166196 (2016)
Serotonin transporter (SERT) modulates serotonergic signaling via re-uptake of serotonin in pre-synaptic cells. The inclusion in cholesterol-enriched membrane domains is crucial for SERT activity, suggesting a cross-talk between the protein and the s
Externí odkaz:
https://doaj.org/article/c05f045af0704097bbccf07087fa0540
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e18845 (2011)
The role of virtual ligand screening in modern drug discovery is to mine large chemical collections and to prioritize for experimental testing a comparatively small and diverse set of compounds with expected activity against a target. Several studies
Externí odkaz:
https://doaj.org/article/94f12c65bb8a49d5b277e07ddf1d2687
Publikováno v:
Expert Opinion on Therapeutic Patents. 32:605-627
Compelling evidence identified D3 dopamine receptor (D3R) as a suitable target for therapeutic intervention on CNS-associated disorders, cancer, and other conditions. Several efforts have been made toward developing potent and selective ligands for m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f455e2bcb7dee7c8d2e106b539252c92
https://doi.org/10.1080/13543776.2022.2049240
https://doi.org/10.1080/13543776.2022.2049240
Autor:
Pedro J. Buigues, Sascha Gehrke, Magd Badaoui, Gaurav Mandana, Tianyun Qi, Giovanni Bottegoni, Edina Rosta
Patient symptom relief is often heavily influenced by the residence time of the inhibitor-target complex. For the human muscarinic receptor 3 (hMR3), tiotropium is a long-acting bronchodylator used in conditions such as asthma or chronic obstructive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8abba514801aafd62537b4205596fb88
https://doi.org/10.1101/2023.01.03.522558
https://doi.org/10.1101/2023.01.03.522558
Autor:
Andrea Armirotti, Debora Russo, Andrea Nuzzi, Paolo Di Fruscia, Daniela Pizzirani, Chiara Pagliuca, Giovanni Bottegoni, Annalisa Fiasella, Ilaria Penna, Jose Antonio Ortega, Elisa Romeo, Francesca Giacomina, Sine Mandrup Bertozzi, Angelo Reggiani, Maria Summa, Anna Carbone, Roberta Giampà, Rosalia Bertorelli, Francesco Berti, Tiziano Bandiera, Luisa Mengatto, Stefano Ponzano, Glauco Tarozzo, Fabio Bertozzi
Publikováno v:
Journal of Medicinal Chemistry
Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25d6abb364b90e4db233d64f4ecf7b3
https://doi.org/10.1021/acs.jmedchem.1c00575
https://doi.org/10.1021/acs.jmedchem.1c00575
Autor:
Sally A, Clayton, Kalbinder K, Daley, Lucy, MacDonald, Erika, Fernandez-Vizarra, Giovanni, Bottegoni, John D, O'Neil, Triin, Major, Daniel, Griffin, Qinqin, Zhuang, Adeolu B, Adewoye, Kieran, Woolcock, Simon W, Jones, Carl, Goodyear, Aziza, Elmesmari, Andrew, Filer, Daniel A, Tennant, Stefano, Alivernini, Christopher D, Buckley, Robert D S, Pitceathly, Mariola, Kurowska-Stolarska, Andrew R, Clark
Publikováno v:
Science Advances
Description
Exchange of mitochondrial subunits C15ORF48 and NDUFA4 occurs during macrophage activation in vitro and in inflammatory disease.
Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory diseases. Cytochr
Exchange of mitochondrial subunits C15ORF48 and NDUFA4 occurs during macrophage activation in vitro and in inflammatory disease.
Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory diseases. Cytochr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::694fbc2690e233a0f9813c0ced70df88
https://pubmed.ncbi.nlm.nih.gov/34878835
https://pubmed.ncbi.nlm.nih.gov/34878835
Autor:
Veronica Lunerti, Hongwu Li, Federica Benvenuti, Qianwei Shen, Ana Domi, Laura Soverchia, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Carolina L. Haass-Koffler, Nazzareno Cannella
Publikováno v:
European journal of pharmacology. 928
Tobacco use disorder is a worldwide health problem for which available medications show limited efficacy. Nicotine is the psychoactive component of tobacco responsible for its addictive liability. Similar to other addictive drugs, nicotine enhances m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fbd78007cfdcc954cc8eb42508bbca
https://pubmed.ncbi.nlm.nih.gov/35690082
https://pubmed.ncbi.nlm.nih.gov/35690082
Autor:
Giuliana Ottonello, Sine Mandrup Bertozzi, Francesca Seghetti, Tiziano Bandiera, Andrea Cavalli, Debora Russo, Ilaria Penna, Alessio De Simone, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Andrea Armirotti, Federica Belluti
Due to the complex and multifactorial nature of bipolar disorder (BD), single-target drugs have traditionally provided limited relief with no disease-modifying effects. In line with the polypharmacology paradigm, we attempted to overcome these limita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2098d5cf611ef8d2875e54562ec21e0
https://hdl.handle.net/11576/2688780
https://hdl.handle.net/11576/2688780
Publikováno v:
Journal of Medicinal Chemistry. 61:619-637
The amyloid hypothesis has long been the central dogma in drug discovery for Alzheimer’s disease (AD), leading to many small-molecule and biological drug candidates. One major target has been the β-site amyloid-precursor-protein-cleaving enzyme 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::795335450668efbd9755031cb21b3c31
https://doi.org/10.1021/acs.jmedchem.7b00393
https://doi.org/10.1021/acs.jmedchem.7b00393
Autor:
Mariarosaria Ferraro, Sergio Decherchi, Maurizio Recanatini, Alessio De Simone, Andrea Cavalli, Giovanni Bottegoni
Local changes in the structure of G-protein coupled receptors (GPCR) binders largely affect their pharmacological profile. While the sought efficacy can be empirically obtained by introducing local modifications, the underlining structural explanatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff25218a301d1c009bcd7634903b5e
https://doi.org/10.26434/chemrxiv.8216060.v1
https://doi.org/10.26434/chemrxiv.8216060.v1