Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Giovanni Aviles"'
Autor:
Valerie Perea, Kelsey R. Baron, Vivian Dolina, Giovanni Aviles, Jessica D. Rosarda, Xiaoyan Guo, Martin Kampmann, R. Luke Wiseman
SUMMARYThe integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead to mitochondrial dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6a162ce65873070004d9fc396c7a99
https://doi.org/10.1101/2023.03.11.532186
https://doi.org/10.1101/2023.03.11.532186
Autor:
Jie Yang, Kelsey R. Baron, Daniel E. Pride, Anette Schneemann, Xiaoyan Guo, Wenqian Chen, Albert S. Song, Giovanni Aviles, Martin Kampmann, R. Luke Wiseman, Gabriel C. Lander
Mitochondria are dynamic organelles that must continually adapt and respond to cellular stress. Recent studies demonstrated that mitochondrial stress can be relayed from mitochondria to the cytosol by the release of a C-terminal proteolytic fragment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c142ef8c6400d7e018dd74dfaea5b31e
https://doi.org/10.1101/2022.10.01.510468
https://doi.org/10.1101/2022.10.01.510468
Autor:
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 9
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd0dd4f4f4a2c727da14efed73b6fb
https://escholarship.org/uc/item/00b6v7cg
https://escholarship.org/uc/item/00b6v7cg
Autor:
Nina M, Dräger, Sydney M, Sattler, Cindy Tzu-Ling, Huang, Olivia M, Teter, Kun, Leng, Sayed Hadi, Hashemi, Jason, Hong, Giovanni, Aviles, Claire D, Clelland, Lihong, Zhan, Joe C, Udeochu, Lay, Kodama, Andrew B, Singleton, Mike A, Nalls, Justin, Ichida, Michael E, Ward, Faraz, Faghri, Li, Gan, Martin, Kampmann
Publikováno v:
Nature neuroscience. 25(9)
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Autor:
Ke Xu, Ruilin Tian, Arun P. Wiita, M. Almira Correia, Giovanni Aviles, Xiaoyan Guo, Yu-Hsiu T. Lin, Martin Kampmann, Yi Liu, Bret A. Unger
Publikováno v:
Nature, vol 579, iss 7799
Nature
Nature
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the induction of the transcription factor ATF41–3. However, how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b676097489bdd1dcc9d3378abdceeca2
https://escholarship.org/uc/item/7gc1126p
https://escholarship.org/uc/item/7gc1126p
Autor:
M. Almira Correia, Arun P. Wiita, Ruilin Tian, Bret A. Unger, Giovanni Aviles, Xiaoyan Guo, Martin Kampmann, Yi Liu, Yu-Hsiu T. Lin, Ke Xu
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response (ISR), in which eIF2α phosphorylation upregulates the transcription factor ATF4. However, how mitochondrial stress is relayed to the ISR is unknown. We found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221222503e2083f00321f04017961ccc