Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Giovanni Abbenante"'
Autor:
Timothy A. Hill, David P. Fairlie, Gloria Ruiz-Gómez, Frederik Diness, Nicholas E. Shepherd, Giovanni Abbenante, Huy N. Hoang, Jody M. Mason, Chongyang Wu
Publikováno v:
Chemical Science. 10:10595-10600
Protein–protein interactions involve hotspots as small as 4 sequential amino acids. Corresponding tetrapeptides have no structure in water. Here we report linking side chains of amino acids X and Z to form 24 cyclic tetrapeptides, cyclo-[XAAZ]-NH2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::398f2aed8914bac6e458761394ec1d60
https://doi.org/10.1039/c9sc04153b
https://doi.org/10.1039/c9sc04153b
Autor:
Huy N, Hoang, Timothy A, Hill, Gloria, Ruiz-Gómez, Frederik, Diness, Jody M, Mason, Chongyang, Wu, Giovanni, Abbenante, Nicholas E, Shepherd, David P, Fairlie
Publikováno v:
Chemical Science
Twisting or turning peptides: ring size and chi angle in side chain cross-linked tetrapeptides together control α- or β-turn structures, which mimic irregular secondary structures in proteins.
Protein–protein interactions involve hotspots as
Protein–protein interactions involve hotspots as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73b0aabd2e8bf285803ee698344cebea
https://pubmed.ncbi.nlm.nih.gov/32110345
https://pubmed.ncbi.nlm.nih.gov/32110345
Autor:
Giovanni Abbenante, Frederik Diness, Timothy A. Hill, Jody M. Mason, Huy N. Hoang, Gloria Ruiz-Gómez, Nicholas E. Shepherd, Chongyang Wu, David P. Fairlie
Publikováno v:
Chemical Science. 11:7511-7511
Correction for ‘Twists or turns: stabilising alpha vs. beta turns in tetrapeptides’ by Huy N. Hoang et al., Chem. Sci., 2019, 10, 10595–10600, DOI: 10.1039/C9SC04153B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eced2ff5243fda1e593123a00eb74378
https://doi.org/10.1039/d0sc90138e
https://doi.org/10.1039/d0sc90138e
Autor:
David P. Fairlie, Michael J. Kelso, Timothy A. Hill, Huy N. Hoang, Nicholas E. Shepherd, W. Mei Kok, Gloria Ruiz-Gómez, Rosemary S. Harrison, Giovanni Abbenante, Renee L. Beyer
Publikováno v:
Tetrahedron. 70:7645-7650
HIV-1 Rev is a 116 residue transporter protein that enters the host cell nucleus and uses its 17 amino acid segment (Rev34–50) to bind and capture a specific piece of RNA, the Rev Response Element (RRE), for transport to the cytoplasm. This is crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::516e26dde7de4353d59410d906344551
https://doi.org/10.1016/j.tet.2014.07.096
https://doi.org/10.1016/j.tet.2014.07.096
Autor:
Gloria Ruiz-Gómez, Jody M. Mason, David P. Fairlie, Giovanni Abbenante, Rosemary S. Harrison, Nicholas E. Shepherd
Publikováno v:
Shepperd, N E, Harrison, R S, Ruiz-Gomez, G, Abbenante, G, Mason, J M & Fairlie, D P 2016, ' Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency ', Organic & Biomolecular Chemistry, vol. 14, no. 46, pp. 10939-10945 . https://doi.org/10.1039/c6ob02185a
Bcl2 Homology (BH) proteins can either trigger or prevent programmed cell death or apoptosis. Deregulation of the BH protein family network leads to evasion of apoptosis, uncontrolled proliferation and is a hallmark of cancer. Inhibition of pro-survi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd5dd020319a20af21d8099957dd42b
https://pubmed.ncbi.nlm.nih.gov/27819377
https://pubmed.ncbi.nlm.nih.gov/27819377
Publikováno v:
Tetrahedron. 68:4513-4516
Left or right handed alpha helicity can be induced in a pentapeptide (ANGYG) by appending left or right handed helical cycles as chiral templates. This sequence corresponds to a rare left handed helix found in the protein alanine racemase. Circular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e07cbc348a89a42d9d4d7420fcae54b
https://doi.org/10.1016/j.tet.2011.10.108
https://doi.org/10.1016/j.tet.2011.10.108
Autor:
Russell W. Driver, Alan E. Mark, Renee L. Beyer, Giang Thanh Le, David P. Fairlie, Huy N. Hoang, Alpeshkumar K. Malde, Giovanni Abbenante
Publikováno v:
Angewandte Chemie International Edition. 50:11107-11111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64dba4e289d1fe82ba3aabee52ac546e
https://doi.org/10.1002/anie.201105119
https://doi.org/10.1002/anie.201105119
Autor:
Giang Le Thanh, Tony Rossetti, Rajaratnam Premraj, Craig Muldoon, Maretta Mann, Matthias Grathwohl, Michael West, Jennifer Waanders, Ligong Liu, Norbert Wimmer, Frank Vari, Giovanni Abbenante, Sébastien Blanc, Johannes Zuegg, Karl Schafer, Graeme Fraser, Geraldine Verquin, Annika Yau, Judy Halliday, Bernd Becker, Glenn Condie, Ann Lam, Senka Henderson, Gerald Tometzki, Andrew G. Pearson, Tracie Elizabeth Ramsdale, Christopher T. Clark, Wim Meutermans
Publikováno v:
Journal of Medicinal Chemistry. 53:5576-5586
Success in discovering bioactive peptide mimetics is often limited by the difficulties in correctly transposing known binding elements of the active peptide onto a small and metabolically more stable scaffold while maintaining bioactivity. Here we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2bdfa9a1b7acf04b17ce5bd3c508f8
https://doi.org/10.1021/jm1002777
https://doi.org/10.1021/jm1002777
Autor:
David P. Fairlie, Gloria Ruiz-Gómez, Bernhard Pfeiffer, Giovanni Abbenante, Joel D. A. Tyndall
Publikováno v:
Chemical Reviews. 110:PR1-PR41
1. GPCRs: Importance and Occurrence G protein-coupled receptors (GPCRs) are seven transmembrane helical bundle proteins (Figure 1) found on the surface of all cells.1–3 They mediate cellular responses to a diverse range of extracellular stimuli, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0256a2a84a7aa44bf757396f7b8171
https://doi.org/10.1021/cr900344w
https://doi.org/10.1021/cr900344w
Publikováno v:
Organic Letters. 11:3092-3095
A protein alpha-helix is defined by 3.6 amino acids per turn. Cyclization of the tripeptide Alanine-Leucine-Glutamate through a side chain to the N-terminus lactam bond produces cyclo-(1,3)-[ALE]-NH(2) which displays a circular dichroism spectrum typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6487ede69b989c0485248e541f6c8c2
https://doi.org/10.1021/ol901181b
https://doi.org/10.1021/ol901181b