Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Giovanni Vitulli"'
Autor:
Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human
Externí odkaz:
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Jack Ayre, Joanna M. Redmond, Giovanni Vitulli, Laura Tomlinson, Richard Weaver, Eleonora Comeo, Cynthia Bosquillon, Michael J. Stocks
Publikováno v:
Journal of Medicinal Chemistry. 65:9802-9818
A major limitation of pulmonary delivery is that drugs can exhibit suboptimal pharmacokinetic profiles resulting from rapid elimination from the pulmonary tissue. This can lead to systemic side effects and a short duration of action. A series of diba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16df6142b80ae58957462c52aa4df53c
https://doi.org/10.1021/acs.jmedchem.2c00416
https://doi.org/10.1021/acs.jmedchem.2c00416
Autor:
Natasja Stæhr Gudmann, Richard P. Marshall, Jeni Luckett, Rebecca F. Rogers, Robert J. Slack, Simon J. F. Macdonald, Diana Julie Leeming, Rachel C. Chambers, Joelle Le, Pauline T. Lukey, Anthony Habgood, Paul F. Mercer, Rachel A. Burgoyne, Ben S. Barksby, Lloyd I. Bibby, Yim Man, Maryam Hafeji, Andrew J. Fisher, David J. Flint, Toby M. Maher, Louise Organ, Susan Pyne, Lee A. Borthwick, James A. Roper, Valerie S. Morrison, Alison E. John, Giovanni Vitulli, Rebecca H. Graves, Rochelle C. Edwards-Pritchard, R. Gisli Jenkins, John Barrett, Josie Morrell, K. Tao Pun, Elaine Gower, Rory Barnes, Ellen J. Forty, Chitra Joseph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule αvβ6 RGD-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4959cf67302e9783a88dddd530b0b
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Christophe Plisson, Lisa Wells, Christine A. Parker, Mayca Onega, Sara Moz, Nicholas Keat, Christopher Coello, Pauline T. Lukey, Giovanni Vitulli, Joaquim Ramada-Magalhaes, Roger N. Gunn, Frederick J. Wilson, Sharon Ashworth, Robert J. Slack, Sac-Pham Tang, Gaia Rizzo, Jan Passchier
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
PurposeIntegrin αvβ6belongs to the RGD subset of the integrin family, and its expression levels are a prognostic and theranostic factor in some types of cancer and pulmonary fibrosis. This paper describes the GMP radiolabelling of the synthetic 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0df9d47daff9ba4eabf23c6dbb7f6ff
http://europepmc.org/articles/PMC7075836
http://europepmc.org/articles/PMC7075836
Autor:
Daniele Barbaro, Lorenzo Di Bari, Valentina Gandin, Claudio Evangelisti, Giovanni Vitulli, Eleonora Schiavi, Cristina Marzano, Anna M Ferretti, Piero Salvadori
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123159 (2015)
Iron oxide nanoparticles (IONP) can have a variety of biomedical applications due to their visualization properties through Magnetic Resonance Imaging (MRI) and heating with radio frequency or alternating magnetic fields. In the oncological field, co
Externí odkaz:
https://doaj.org/article/fab5b45f7d494ff99bf926c53498196e
Autor:
Malcolm Begg, Eleni Pefani, Jonathan Clark, Carla F. Newman, Miriam Marotti, Martin I. Hingle, Disala Fernando, David N. Mallett, Anthony Cahn, Sorif Uddin, Filzah Ehtesham, Josie Morrell, Robert Wilson, Giovanni Vitulli, J. Nicole Hamblin, Jane Gilbert, Chris D. Edwards, Edith M. Hessel, Andrew W Harrell
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:443-453
This study describes the pharmacokinetic (PK) and pharmaco-dynamic (PD) profile of N-(5-(4-(5-(((2R,6S)-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide (GSK2292767A), a novel low-solubility inhaled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d458b382120aa5c2397a9f4a956bd6f
https://doi.org/10.1124/jpet.119.257311
https://doi.org/10.1124/jpet.119.257311
Autor:
Richard P. Marshall, John Martin Pritchard, Josie Morrell, Simon J. F. Macdonald, Seble Lemma, John F. Barrett, Paula Saklatvala, Robert J. Slack, Panayiotis A. Procopiou, Joelle Le, Tim N. Barrett, Ashley Paul Hancock, James E. Rowedder, Matthew H. J. Crawford, Anderson Niall Andrew, Giovanni Vitulli, Colin J. Suckling, Brendan J. Fallon, Steven L. Sollis, Lee R. Thorp
Publikováno v:
Journal of Medicinal Chemistry. 61:8417-8443
A series of 3-aryl(pyrrolidin-1-yl)butanoic acids were synthesized using a diastereoselective route, via a rhodium catalyzed asymmetric 1,4-addition of arylboronic acids in the presence of (R)-BINAP to a crotonate ester to provide the (S) absolute co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5661106b41cca877b5043e391b8cef81
https://doi.org/10.1021/acs.jmedchem.8b00959
https://doi.org/10.1021/acs.jmedchem.8b00959
Autor:
Joelle Le, Sharon Butler, James E. Rowedder, Stephen M. Harrison, John Martin Pritchard, Anderson Niall Andrew, Claire E. Smith, Rosemary Maghames, Simon J. F. Macdonald, Aleix Pastor-Garcia, Sebastien Andre Campos, Giovanni Vitulli, Jack Thomas, Royston C. B. Copley, Ian B. Duncan
Publikováno v:
Journal of medicinal chemistry. 62(19)
The heterodimeric transmembrane αv integrin receptors have recently emerged as potential targets for the treatment of idiopathic pulmonary fibrosis. Herein, we describe how subtle modifications of the central aromatic ring of a series of phenylbutyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26214873182de29f352e72fc31366e1a
https://pubmed.ncbi.nlm.nih.gov/31497959
https://pubmed.ncbi.nlm.nih.gov/31497959
Autor:
Tim N, Barrett, Jonathan A, Taylor, Daniel, Barker, Panayiotis A, Procopiou, James D F, Thompson, John, Barrett, Joelle, Le, Sean M, Lynn, Peter, Pogany, Cassie, Pratley, John M, Pritchard, James A, Roper, James E, Rowedder, Robert J, Slack, Giovanni, Vitulli, Simon J F, Macdonald, William J, Kerr
Publikováno v:
Journal of medicinal chemistry. 62(16)
A quaternary ammonium betaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae21e6f21b6a818880bded8dabca0287
https://pubmed.ncbi.nlm.nih.gov/31381331
https://pubmed.ncbi.nlm.nih.gov/31381331
Autor:
Sorif Uddin, Graham G. A. Inglis, Paul Rowland, Christopher J. Tame, Christopher N. Luscombe, Nick Barton, Natalie Wellaway, Anthony William James Cooper, Josie Morrell, Giovanni Vitulli, David Perez, Augustin Amour, Simon Peace, Craig Jamieson
Publikováno v:
Journal of Medicinal Chemistry. 59:7239-7251
A four step process of high quality modelling of existing data, deconstruction, identification of replacement cores and an innovative synthetic re-growth strategy led to the rapid discovery of a novel oral series of PI3K δ inhibitors with promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab7b0c93c6a62dbb34f4fe7ac3288ff
https://doi.org/10.1021/acs.jmedchem.6b00799
https://doi.org/10.1021/acs.jmedchem.6b00799