Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Giovanni Muncipinto"'
Publikováno v:
Frontiers in Chemistry, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/f0f6c83024fd49b0a1df7e3dd3ae0306
Autor:
Leonardo Pisani, Marco Catto, Giovanni Muncipinto, Orazio Nicolotti, Antonio Carrieri, Mariagrazia Rullo, Angela Stefanachi, Francesco Leonetti, Cosimo Altomare
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The coumarin core (i.e., 1-benzopyran-2 (2H)-one) is a structural motif highly recurrent in both natural products and bioactive molecules. Indeed, depending on the substituents and branching positions around the byciclic core, coumarin-containing com
Externí odkaz:
https://doaj.org/article/53ff1d25b4064b7f8ec8c3ec6647bf7d
Autor:
Heike Wobst, Ryan Hollibaugh, Giovanni Muncipinto, Christopher Burkhart, Daniel van Kalken, Andreu Viader, Heather Blanchette, Dean Brown, Nick Pullen, John Throup, Joel Barrish
Publikováno v:
Molecular Genetics and Metabolism. 138:107502
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e27d4c556d321df361eaf7d97318ebb7
https://doi.org/10.1016/j.ymgme.2023.107502
https://doi.org/10.1016/j.ymgme.2023.107502
Autor:
Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary Clish, Kiran Musunuru, Jeremy R Duvall, Michael Foley, Jose R Perez, Michelle A J Palmer
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120295 (2015)
Recent genome wide association studies have linked tribbles pseudokinase 1 (TRIB1) to the risk of coronary artery disease (CAD). Based on the observations that increased expression of TRIB1 reduces secretion of VLDL and is associated with lower plasm
Externí odkaz:
https://doaj.org/article/462e5962fcb24652928b7b20d53c53e5
Autor:
Andrew C. Huang, Lyn H. Jones, Giovanni Muncipinto, Christina M. Woo, Hung-Yi Wu, Matthew T Labenski, Alexander V West
Publikováno v:
Journal of the American Chemical Society. 143(17)
Diazirines are widely used in photoaffinity labeling (PAL) to trap noncovalent interactions with biomolecules. However, design and interpretation of PAL experiments is challenging without a molecular understanding of the reactivity of diazirines with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a254a2d10ff9ac96ad000cc37b1f3351
https://pubmed.ncbi.nlm.nih.gov/33876925
https://pubmed.ncbi.nlm.nih.gov/33876925
Autor:
Alexander West, Giovanni Muncipinto, Hung-Yi Wu, Andrew Huang, Matthew T. Labenski, Christina Woo
Diazirines are widely used in photoaffinity labeling (PAL) to trap non-covalent interactions with biomolecules. However, design and interpretation of PAL experiments is challenging without a molecular understanding of the reactivity of diazirines wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e84cae97e902edac594b3469ddbff60
https://doi.org/10.26434/chemrxiv.13373249
https://doi.org/10.26434/chemrxiv.13373249
Autor:
Wenye Sun, Zhenmin He, Adel M. Naylor-Olsen, Deming Xu, Joseph P. Vacca, Leanne Bedard, Ashlee M. Earl, Christina Scherer, Abigail L. Manson, Maurice D. Lee, Diane M Rush, Mark E. Fitzgerald, Mingliang Zhang, Huisheng Xu, Michelle Palmer, Joshua A. Bittker, Michael Foley, Jean-Charles Marie, Jeremy R. Duvall, Giovanni Muncipinto
Publikováno v:
ACS Infectious Diseases. 3:349-359
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f791f91a622ab9ee165e311f645c00d1
https://doi.org/10.1021/acsinfecdis.6b00206
https://doi.org/10.1021/acsinfecdis.6b00206
Autor:
Björn Over, Pär Matsson, Christian Tyrchan, Per Artursson, Bradley C Doak, Michael A Foley, Constanze Hilgendorf, Stephen E Johnston, Maurice D Lee, Richard J Lewis, Patrick McCarren, Giovanni Muncipinto, Ulf Norinder, Matthew W D Perry, Jeremy R Duvall, Jan Kihlberg
Publikováno v:
Nature chemical biology. 13(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d073186a58bd18321be66aba97fa427
https://pubmed.ncbi.nlm.nih.gov/27748751
https://pubmed.ncbi.nlm.nih.gov/27748751
Autor:
Daniela Masi, Keila N. Crespo-Llado, Amanda K. Lukens, Roger C. Wiegand, Dyann F. Wirth, Ann Rowley, Jeremy R. Duvall, Richard W. Heidebrecht, Mark E. Fitzgerald, Michael Foley, Adelfa E. Serrano, Nobutaka Kato, Stuart L. Schreiber, Marion Mercier, Benito Munoz, Carol A. Mulrooney, Christina Scherer, Eamon Comer, Maurice D. Lee, Michelle Palmer, Giovanni Muncipinto, Jennifer A. Beaudoin
Publikováno v:
Journal of Medicinal Chemistry
Here, we describe medicinal chemistry that was accelerated by a diversity-oriented synthesis (DOS) pathway, and in vivo studies of our previously reported macrocyclic antimalarial agent that derived from the synthetic pathway. Structure–activity re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0a1ed1bf52387b6cc5aab71452f65c
http://europepmc.org/articles/PMC4207553
http://europepmc.org/articles/PMC4207553
Autor:
Carol A. Mulrooney, Morgan Welzel-O’Shea, Bérénice C. Lemercier, Edward B. Holson, Landon Durak, Sarathy Kesavan, Jeremy R. Duvall, Jingqiang Wei, Florence F. Wagner, Adrien Joliton, Laura M. Panko, Maurice D. Lee, Lisa A. Marcaurelle, Lakshmi B. Akella, Haibo Liu, Emeline L. Davoine, Jason T. Lowe, Méryl Thomas, Etienne J. Donckele, Michael Foley, Byung-Chul Suh, Giovanni Muncipinto, Ann Rowley, Jean-Charles Marie, Baudouin Gerard
Publikováno v:
The Journal of Organic Chemistry. 77:7187-7211
The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8203c3d71af27e48bd78615da92d79b3
https://doi.org/10.1021/jo300974j
https://doi.org/10.1021/jo300974j