Zobrazeno 1 - 10
of 347
pro vyhledávání: '"Giovanni Maga"'
Autor:
Salvatore Princiotto, Loana Musso, Fabrizio Manetti, Valentina Marcellini, Giovanni Maga, Emmanuele Crespan, Cecilia Perini, Nadia Zaffaroni, Giovanni Luca Beretta, Sabrina Dallavalle
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2382-2394 (2022)
Inhibition of c-Src is considered one of the most studied approaches to cancer treatment, with several heterocyclic compounds approved during the last 15 years as chemotherapeutic agents. Starting from the biological evaluation of an in-house collect
Externí odkaz:
https://doaj.org/article/95aeb38bd14c4805af558781c3254a39
Autor:
Claudia Contadini, Claudia Cirotti, Anna Carbone, Mehrdad Norouzi, Annarita Cianciusi, Emmanuele Crespan, Cecilia Perini, Giovanni Maga, Daniela Barilà, Francesca Musumeci, Silvia Schenone
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 958 (2023)
Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as Src and/or
Externí odkaz:
https://doaj.org/article/cb6c5b3f3a3c4429a456fa6d37613bc6
Autor:
Camilla Lodola, Massimiliano Secchi, Virginia Sinigiani, Antonella De Palma, Rossana Rossi, Davide Perico, Pier Luigi Mauri, Giovanni Maga
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5784 (2023)
The nucleocapsid protein Np of SARS-CoV-2 is involved in the replication, transcription, and packaging of the viral genome, but it also plays a role in the modulation of the host cell innate immunity and inflammation response. Ectopic expression of N
Externí odkaz:
https://doaj.org/article/a0185db3013f451a84e5f5b8d0d467ed
Autor:
Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Emmanuele Crespan, Giovanni Maga, Cecilia Perini, Noemi Cabella, Lorenzo Botta, Francesca Musumeci, Maria Frosini, Silvia Schenone, Elena Dreassi
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 453 (2023)
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual
Externí odkaz:
https://doaj.org/article/ccd671932b5b41839203be632d83a138
Autor:
Silvia Cesarini, Ilaria Vicenti, Federica Poggialini, Massimiliano Secchi, Federica Giammarino, Ilenia Varasi, Camilla Lodola, Maurizio Zazzi, Elena Dreassi, Giovanni Maga, Lorenzo Botta, Raffaele Saladino
Publikováno v:
Molecules, Vol 27, Iss 24, p 8829 (2022)
Current therapy against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are based on the use of Remdesivir 1, Molnupiravir 2, and the recently identified Nirmatrelvir 3. Unfortunately, these three drugs showed some limitations regar
Externí odkaz:
https://doaj.org/article/c0abea2af9b042f980b54cd2f982ba34
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in
Autor:
Enrico Rango, Salvatore Di Maria, Claudio Zamperini, Federica Poggialini, Emmanuele Crespan, Cecilia Perini, Samantha Sabetta, Simona Saponara, Fabio Fusi, Giovanni Maga, Adriano Angelucci, Eugenio Gaudio, Francesco Berton, Silvia Schenone, Lorenzo Botta, Elena Dreassi, Maurizio Botta
Publikováno v:
Pharmaceutical Chemistry Journal. 56:1616-1626
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::234f0006daf6b3240551930e53465813
https://doi.org/10.1007/s11094-023-02836-x
https://doi.org/10.1007/s11094-023-02836-x
Autor:
Chiara Lico, Luca Santi, Selene Baschieri, Emanuela Noris, Carla Marusic, Marcello Donini, Emanuela Pedrazzini, Giovanni Maga, Rosella Franconi, Paola Di Bonito, Linda Avesani
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 37,000 people in Italy and has caused widespread socioeconomic disruption. Urgent measures are needed to contain and control the virus, particularly diagnostic kits for
Externí odkaz:
https://doaj.org/article/8a1d21396c9b46efb08d340f16406ba9
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
As intracellular parasites, viruses hijack the host cell metabolic machinery for their replication. Among other cellular proteins, the DEAD-box (DDX) RNA helicases have been shown to be hijacked by coronaviruses and to participate in essential DDX-me
Externí odkaz:
https://doaj.org/article/0dc6f06578dc42d3abd41bcb5e93cb53
Autor:
Schenone, Claudia Contadini, Claudia Cirotti, Anna Carbone, Mehrdad Norouzi, Annarita Cianciusi, Emmanuele Crespan, Cecilia Perini, Giovanni Maga, Daniela Barilà, Francesca Musumeci, Silvia
Publikováno v:
Pharmaceuticals; Volume 16; Issue 7; Pages: 958
Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as Src and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::43d6f80167150a87d487441daa4aef0d