Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Giovanni, Stracquadanio"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Engineering proteins is a challenging task requiring the exploration of a vast design space. Traditionally, this is achieved using Directed Evolution (DE), which is a laborious process. Generative deep learning, instead, can learn biological
Externí odkaz:
https://doaj.org/article/6a9535bb78214daeb951d615776b6680
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Engineering proteins with desired functions and biochemical properties is pivotal for biotechnology and drug discovery. While computational methods based on evolutionary information are reducing the experimental burden by designing targeted
Externí odkaz:
https://doaj.org/article/0b8ea6f5ae99438e885e3bfce0a661c8
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Gene and protein interaction experiments provide unique opportunities to study the molecular wiring of a cell. Integrating high-throughput functional genomics data with this information can help identifying networks associated wit
Externí odkaz:
https://doaj.org/article/fc05c284c9d44b4bbbbe3e197d2758dd
Autor:
Gareth L. Bond, Hannah Carter, Clare Turnbull, Ian Tomlinson, Enric Domingo, Timothy S. Maughan, Sarah P. Blagden, Meghana Pagadala, Daniel V. Ebner, Val Millar, Andrew Protheroe, Claire Palles, Lukasz F. Grochola, Rick Jansen, Chey Loveday, Paul D. Pharoah, Siddhartha Kar, Janet Shipley, Joanna L. Selfe, Anderson J. Ryan, Yanyan Jiang, Jorge Zeron-Medina, Douglas A. Bell, Xuting Wang, David Sims, Mirvat Surakhy, Sarah De Val, Svanhild Nornes, Samantha Moore, Natasha Sahgal, Elisabeth Bond, Marsha D. Wallace, Philipp H. Richter, Katherine Brown, Giovanni Stracquadanio, Lingyun Xiong, Isaac Kitchen-Smith, Ping Zhang
Insights into oncogenesis derived from cancer susceptibility loci (SNP) hold the potential to facilitate better cancer management and treatment through precision oncology. However, therapeutic insights have thus far been limited by our current lack o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48068f754d392811955bcd8091e2b19e
https://doi.org/10.1158/0008-5472.c.6513219.v1
https://doi.org/10.1158/0008-5472.c.6513219.v1
Autor:
Gareth L. Bond, Hannah Carter, Clare Turnbull, Ian Tomlinson, Enric Domingo, Timothy S. Maughan, Sarah P. Blagden, Meghana Pagadala, Daniel V. Ebner, Val Millar, Andrew Protheroe, Claire Palles, Lukasz F. Grochola, Rick Jansen, Chey Loveday, Paul D. Pharoah, Siddhartha Kar, Janet Shipley, Joanna L. Selfe, Anderson J. Ryan, Yanyan Jiang, Jorge Zeron-Medina, Douglas A. Bell, Xuting Wang, David Sims, Mirvat Surakhy, Sarah De Val, Svanhild Nornes, Samantha Moore, Natasha Sahgal, Elisabeth Bond, Marsha D. Wallace, Philipp H. Richter, Katherine Brown, Giovanni Stracquadanio, Lingyun Xiong, Isaac Kitchen-Smith, Ping Zhang
Supplementary Methods; Supplementary Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c5eb435e059e37b7df5dbe2572af66
https://doi.org/10.1158/0008-5472.22429038.v1
https://doi.org/10.1158/0008-5472.22429038.v1
Autor:
Lukasz F. Grochola, Gareth L. Bond, Rolf Graf, Pierre-Alain Clavien, Stefan Breitenstein, Doris Henne-Bruns, Uwe Knippschild, Thomas H. Müller, Peter Würl, Peter Schraml, Renata Flury, Bart Vrugt, Giovanni Stracquadanio
Purpose: Although pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor, like other common cancers, it displays a wide range of biology. However, at present, there are no reliable tests to predict patients' cancer-specific outcomes and guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81fd06ca9efef87754c522470b302ffa
https://doi.org/10.1158/1078-0432.c.6526842
https://doi.org/10.1158/1078-0432.c.6526842
Genome-wide association studies (GWAS) have found hundreds of single-nucleotide polymorphisms (SNP) associated with increased risk of cancer. However, the amount of heritable risk explained by SNPs is limited, leaving most of the cancer heritability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267c89bd9d8ae569db6a171d526e72a4
https://doi.org/10.1158/0008-5472.c.6512527.v1
https://doi.org/10.1158/0008-5472.c.6512527.v1
Autor:
Lukasz F. Grochola, Gareth L. Bond, Rolf Graf, Pierre-Alain Clavien, Stefan Breitenstein, Doris Henne-Bruns, Uwe Knippschild, Thomas H. Müller, Peter Würl, Peter Schraml, Renata Flury, Bart Vrugt, Giovanni Stracquadanio
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459d4cc71413730378d9c4e7f045d31c
https://doi.org/10.1158/1078-0432.22468113.v1
https://doi.org/10.1158/1078-0432.22468113.v1
Autor:
Lukasz F. Grochola, Gareth L. Bond, Rolf Graf, Pierre-Alain Clavien, Stefan Breitenstein, Doris Henne-Bruns, Uwe Knippschild, Thomas H. Müller, Peter Würl, Peter Schraml, Renata Flury, Bart Vrugt, Giovanni Stracquadanio
Supplemental data legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c230564e982a6d5fa14b04ea6d746
https://doi.org/10.1158/1078-0432.22468119.v1
https://doi.org/10.1158/1078-0432.22468119.v1
Supplementary Methods, Figures, Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb8b6b442ea7e6e746b25a2488eb25c
https://doi.org/10.1158/0008-5472.22427035
https://doi.org/10.1158/0008-5472.22427035