Bayesian tomography using polynomial chaos expansion and deep generative networks

Autor: Meles, Giovanni Angelo, Amaya, Macarena, Levy, Shiran, Marelli, Stefano, Linde, Niklas

Implementations of Markov chain Monte Carlo (MCMC) methods need to confront two fundamental challenges: accurate representation of prior information and efficient evaluation of likelihoods. Principal component analysis (PCA) and related techniques ca

Externí odkaz: http://arxiv.org/abs/2307.04228

Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery

Autor: Flore Sinturel, Simona Chera, Marie-Claude Brulhart-Meynet, Jonathan Paz Montoya, Etienne Lefai, François R. Jornayvaz, Giovanni D’Angelo, Minoa Karin Jung, Zoltan Pataky, Howard Riezman, Charna Dibner

Publikováno v: iScience, Vol 27, Iss 9, Pp 110820- (2024)

Summary: Besides its beneficial effect on weight loss, gastric bypass surgery (GBS) may impact the circulating levels of phospho- and sphingolipids. However, long-term effects have not been explored.To investigate alterations in lipidomic signatures

Externí odkaz: https://doaj.org/article/be872104e1e649c4af2f67c73124d830

Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS

Autor: Shannon C. David, Oscar Vadas, Irina Glas, Aline Schaub, Beiping Luo, Giovanni D'angelo, Jonathan Paz Montoya, Nir Bluvshtein, Walter Hugentobler, Liviana K. Klein, Ghislain Motos, Marie Pohl, Kalliopi Violaki, Athanasios Nenes, Ulrich K. Krieger, Silke Stertz, Thomas Peter, Tamar Kohn

Publikováno v: mSphere, Vol 8, Iss 5 (2023)

ABSTRACT Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus infectivity. Indoors, small exhaled aer

Externí odkaz: https://doaj.org/article/a6bed9043c63434cac37f831c28bbc45

Relationship between Lifestyle Determinants and Perceived Mental and Physical Health in Italian Nursery and Primary School Teachers after the COVID-19 Lockdown

Autor: Antonino Scardina, Garden Tabacchi, Ewan Thomas, Giovanni Angelo Navarra, Luca Petrigna, Giovanni Caramazza, Antonio Palma, Marianna Bellafiore

Publikováno v: Journal of Functional Morphology and Kinesiology, Vol 9, Iss 1, p 33 (2024)

The COVID-19 lockdown and the consequent distance school learning made epochal changes in children’s lifestyles; however, little is known about the lockdown effects on school teacher habits. The aim of this observational study is to examine differe

Externí odkaz: https://doaj.org/article/d8579cd887794c959f77807df26aa96f

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Autor: Charlotte Gehin, Museer A. Lone, Winston Lee, Laura Capolupo, Sylvia Ho, Adekemi M. Adeyemi, Erica H. Gerkes, Alexander P.A. Stegmann, Estrella López-Martín, Eva Bermejo-Sánchez, Beatriz Martínez-Delgado, Christiane Zweier, Cornelia Kraus, Bernt Popp, Vincent Strehlow, Daniel Gräfe, Ina Knerr, Eppie R. Jones, Stefano Zamuner, Luciano A. Abriata, Vidya Kunnathully, Brandon E. Moeller, Anthony Vocat, Samuel Rommelaere, Jean-Philippe Bocquete, Evelyne Ruchti, Greta Limoni, Marine Van Campenhoudt, Samuel Bourgeat, Petra Henklein, Christian Gilissen, Bregje W. van Bon, Rolph Pfundt, Marjolein H. Willemsen, Jolanda H. Schieving, Emanuela Leonardi, Fiorenza Soli, Alessandra Murgia, Hui Guo, Qiumeng Zhang, Kun Xia, Christina R. Fagerberg, Christoph P. Beier, Martin J. Larsen, Irene Valenzuela, Paula Fernández-Álvarez, Shiyi Xiong, Robert Śmigiel, Vanesa López-González, Lluís Armengol, Manuela Morleo, Angelo Selicorni, Annalaura Torella, Moira Blyth, Nicola S. Cooper, Valerie Wilson, Renske Oegema, Yvan Herenger, Aurore Garde, Ange-Line Bruel, Frederic Tran Mau-Them, Alexis B.R. Maddocks, Jennifer M. Bain, Musadiq A. Bhat, Gregory Costain, Peter Kannu, Ashish Marwaha, Neena L. Champaigne, Michael J. Friez, Ellen B. Richardson, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, Yask Gupta, Tze Y. Lim, Simone Sanna-Cherchi, Bruno Lemaitre, Toshiyuki Yamaji, Kentaro Hanada, John E. Burke, Ana Marjia Jakšić, Brian D. McCabe, Paolo De Los Rios, Thorsten Hornemann, Giovanni D’Angelo, Vincenzo A. Gennarino

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesi

Externí odkaz: https://doaj.org/article/47a113198d5649e88315ddec99f2067f