Výsledky vyhledávání - "Giovanni, Bertalot"

Akademický článek

TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype

Autor: Mariadomenica Lupi, Daniele Avanzato, Stefano Confalonieri, Flavia Martino, Rosa Pennisi, Emanuela Pupo, Valentina Audrito, Stefano Freddi, Giovanni Bertalot, Francesca Montani, Bronislava Matoskova, Sara Sigismund, Pier Paolo Di Fiore, Letizia Lanzetti

Publikováno v: Cell Death and Disease, Vol 15, Iss 9, Pp 1-14 (2024)

Abstract Metabolic plasticity is a hallmark of cancer, and metabolic alterations represent a promising therapeutic target. Since cellular metabolism is controlled by membrane traffic at multiple levels, we investigated the involvement of TBC1 domain-

Externí odkaz: https://doaj.org/article/43797c9071184cd3a3653f520685ea16

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Akademický článek

ETV7 reduces inflammatory responses in breast cancer cells by repressing the TNFR1/NF-κB axis

Autor: Erna Marija Meškytė, Laura Pezzè, Laura Bartolomei, Mattia Forcato, Irene Adelaide Bocci, Giovanni Bertalot, Mattia Barbareschi, Leticia Oliveira-Ferrer, Alessandra Bisio, Silvio Bicciato, Daiva Baltriukienė, Yari Ciribilli

Publikováno v: Cell Death and Disease, Vol 14, Iss 4, Pp 1-16 (2023)

Abstract The transcription factor ETV7 is an oncoprotein that is up-regulated in all breast cancer (BC) types. We have recently demonstrated that ETV7 promoted breast cancer progression by increasing cancer cell proliferation and stemness and was als

Externí odkaz: https://doaj.org/article/854c0a1107604971b08955fb2db50d34

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Akademický článek

Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 7, p 3967 (2024)

High-grade gliomas (HGGs) and glioblastoma multiforme (GBM) are characterized by a heterogeneous and aggressive population of tissue-infiltrating cells that promote both destructive tissue remodeling and aberrant vascularization of the brain. The for

Externí odkaz: https://doaj.org/article/dfe3f3cb50aa475ca17ea2aed7889a1b

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Akademický článek

GZMKhigh CD8+ T effector memory cells are associated with CD15high neutrophil abundance in non-metastatic colorectal tumors and predict poor clinical outcome

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

The tumor immune microenvironment is an important prognostic determinant in colorectal cancer (CRC). Here the authors show that tumor infiltrating neutrophils expressing high levels of CD15 interact with CD8+ T effector memory skewing them to produce

Externí odkaz: https://doaj.org/article/d39113774e5e4720a4cf6ac291ef21d3

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Akademický článek

L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling

Autor: Marco Giordano, Alessandra Decio, Chiara Battistini, Micol Baronio, Fabrizio Bianchi, Alessandra Villa, Giovanni Bertalot, Stefano Freddi, Michela Lupia, Maria Giovanna Jodice, Paolo Ubezio, Nicoletta Colombo, Raffaella Giavazzi, Ugo Cavallaro

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)

Abstract Background Cancer stem cells (CSC) have been implicated in tumor progression. In ovarian carcinoma (OC), CSC drive tumor formation, dissemination and recurrence, as well as drug resistance, thus contributing to the high death-to-incidence ra

Externí odkaz: https://doaj.org/article/ad85c4ef74d047668cf54b3776191384

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Akademický článek

IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules

Autor: Sara Bisi, Stefano Marchesi, Abrar Rizvi, Davide Carra, Galina V. Beznoussenko, Ines Ferrara, Gianluca Deflorian, Alexander Mironov, Giovanni Bertalot, Federica Pisati, Amanda Oldani, Angela Cattaneo, Ghazaleh Saberamoli, Salvatore Pece, Giuseppe Viale, Angela Bachi, Claudio Tripodo, Giorgio Scita, Andrea Disanza

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the

Externí odkaz: https://doaj.org/article/536a71339aa54d258f9d3f43f9fc0c19

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Akademický článek

A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a

Externí odkaz: https://doaj.org/article/13d80ead99db4faeaae47bea7bd4c693

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Akademický článek

Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive studyResearch in context

Autor: Salvatore Pece, Davide Disalvatore, Daniela Tosoni, Manuela Vecchi, Stefano Confalonieri, Giovanni Bertalot, Giuseppe Viale, Marco Colleoni, Paolo Veronesi, Viviana Galimberti, Pier Paolo Di Fiore

Publikováno v: EBioMedicine, Vol 42, Iss , Pp 352-362 (2019)

Background: Breast cancers show variations in the number and biological aggressiveness of cancer stem cells that correlate with their clinico-prognostic and molecular heterogeneity. Thus, prognostic stratification of breast cancers based on cancer st

Externí odkaz: https://doaj.org/article/b40e7dcb6f9047acbd9737927b3ce038

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