The vitamin D paradox in Black Americans: a systems-based approach to investigating clinical practice, research, and public health - expert panel meeting report

Autor: LaVerne L. Brown, Barbara Cohen, Derrick Tabor, Giovanna Zappalà, Padma Maruvada, Paul M. Coates

Publikováno v: BMC Proceedings, Vol 12, Iss S6, Pp 1-10 (2018)

Abstract The Office of Dietary Supplements, the National Institute on Minority Health and Health Disparities, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases, all components of the U.S. Nation

Externí odkaz: https://doaj.org/article/5df71a739089432a8c2f21ca14a721ff

Improving Natural Product Research Translation: from Source to Clinical Trial

Autor: Jacqueline M. Stephens, Barbara C. Sorkin, Mahtab Jafari, Paula N. Brown, Naomi K. Fukagawa, D. Craig Hopp, Mario G. Ferruzzi, Kathleen R. Pritchett-Corning, Jeffrey Paul, Hervé Tiriac, Daniel Lakens, Bruce Barrett, Floyd H. Chilton, Sara K. Quinney, Dan Xi, Barbara Rehermann, John B. MacMillan, Freddie Ann Hoffman, Nisha S. Sipes, David O. Meltzer, Christopher S. Coffey, Adam J. Kuszak, Frederic D. Bushman, Kenneth D.R. Setchell, D. Lansing Taylor, Gregory Bloss, Giovanna Zappalà, Marco Pahor, Michael A. Walters, Mairead Kiely, Steven J. Casper, Guido F. Pauli

Publikováno v: FASEB J
The FASEB Journal, 34(1), 41-65. FASEB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol 34, iss 1

While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally considered the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d69c2a017736fe5f583f3cc013b079
https://europepmc.org/articles/PMC7470648/

The vitamin D paradox in Black Americans: a systems-based approach to investigating clinical practice, research, and public health - expert panel meeting report

Autor: Barbara E. Cohen, Paul M. Coates, Padma Maruvada, Derrick C. Tabor, Giovanna Zappalà, LaVerne L. Brown

Publikováno v: BMC Proceedings
BMC Proceedings, Vol 12, Iss S6, Pp 1-10 (2018)

The Office of Dietary Supplements, the National Institute on Minority Health and Health Disparities, the National Institute on Aging, and the National Institute of Diabetes and Digestive and Kidney Diseases, all components of the U.S. National Instit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9269212842b5a7e34fd1fbe57328f912
https://doi.org/10.1186/s12919-018-0102-4

IGFBP-3, hypoxia and TNF-α inhibit adiponectin transcription

Autor: Giovanna Zappalà, Matthew M. Rechler

Publikováno v: Biochemical and Biophysical Research Communications. 382:785-789

The thiazolidinedione rosiglitazone, an agonist ligand for the nuclear receptor PPAR-gamma, improves insulin sensitivity in part by stimulating transcription of the insulin-sensitizing adipokine adiponectin. It activates PPAR-gamma-RXR-alpha heterodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a41cac4f8e1c8a294bb15919b9dd5c
https://doi.org/10.1016/j.bbrc.2009.03.112

Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha

Autor: Cem Elbi, Matthew M. Rechler, Giovanna Zappalà, Nisan Bhattacharyya, Julie Gorenstein, Joanna Edwards

Publikováno v: Endocrinology. 149(4)

IGF binding protein (IGFBP)-3 can induce apoptosis in human prostate cancer cells directly without sequestering IGF-I and -II. The molecular mechanisms responsible for the IGF-independent actions of IGFBP-3 remain unclear. IGFBP-3, a secreted protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894521496904ae17eb0ee36f4e6ebdf5
https://pubmed.ncbi.nlm.nih.gov/18162523