Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties

Autor: Maria Luisa Mangoni, Giuseppantonio Maisetta, Giorgia Manzo, Andrea Giuliani, Vincenzo Luca, Manuela Pintus, Giovanna Batoni, Giovanna Pirri, Andrea Rinaldi, Mariano Casu, Anne S. Ulrich, Parvesh Wadhwani, Ilaria Serra, Mariano Andrea Scorciapino

Peptide-based antibiotics might help containing the rising tide of antimicrobial resistance. We developed SB056, a semi-synthetic peptide with a dimeric dendrimer scaffold, active against both Gram-negative and Gram-positive bacteria. Being the mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f832e131bdf124a1f9eb6b435b842e
http://hdl.handle.net/11568/760755

Identification of a Dendrimeric Heparan Sulfate-Binding Peptide That Inhibits Infectivity of Genital Types of Human Papillomaviruses

Autor: Donatella Allemand, Marco Rusnati, Antonella Bugatti, Andrea Giuliani, David Lembo, Manuela Donalisio, Giovanna Pirri, Andrea Civra, Santo Landolfo

Publikováno v: Antimicrobial Agents and Chemotherapy

Peptide dendrimers consist of a peptidyl branching core and/or covalently attached surface functional units. They show a variety of biological properties, including antiviral activity. In this study, a minilibrary of linear, dimeric, and dendrimeric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b0b828e7b7df028b3542ce0be62d26
https://doi.org/10.1128/aac.00471-10

Lipopeptides as anti-infectives: a practical perspective

Autor: Silvia Fabiole Nicoletto, Giovanna Pirri, Lorena Pizzuto, Andrea Rinaldi, Andrea Giuliani

Publikováno v: Open Life Sciences, Vol 4, Iss 3, Pp 258-273 (2009)

Lipopeptide antibiotics represent an old class of antibiotics that were discovered over 50 years ago, which includes the old polymyxins but also new entries, such as the recently approved daptomycin. They generally consist of a hydrophilic cyclic pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e472076416e6123683ede7bc532a4c58
https://doi.org/10.2478/s11535-009-0031-3

Antimicrobial peptides: an overview of a promising class of therapeutics

Autor: Andrea Giuliani, Silvia Fabiole Nicoletto, Giovanna Pirri

Publikováno v: Open Life Sciences, Vol 2, Iss 1, Pp 1-33 (2007)

Antibiotic resistance is increasing at a rate that far exceeds the pace of new development of drugs. Antimicrobial peptides, both synthetic and from natural sources, have raised interest as pathogens become resistant against conventional antibiotics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d144580c78231a72486d4b32b87ce4
https://doi.org/10.2478/s11535-007-0010-5

Peptide microarrays for the characterization of antigenic regions of human chromogranin A

Autor: Francesco Damin, Renato Longhi, Angelo Corti, Marcella Chiari, Marina Cretich, Giovanna Pirri

Publikováno v: Proteomics (Weinh., Print) 5 (2005): 3600–3603.
info:cnr-pdr/source/autori:Chiari M.; Cretich M.; Corti A.; Damin F.; Pirri G.; Longhi R./titolo:Peptide microarrays for the characterization of antigenic regions of human chromogranin A/doi:/rivista:Proteomics (Weinh., Print)/anno:2005/pagina_da:3600/pagina_a:3603/intervallo_pagine:3600–3603/volume:5

Microarraying peptides is a powerful proteomics technique for studying molecular recognition events. Since peptides have small molecular mass, they are not easily accessible when adsorbed onto solid supports. Moreover, peptides can lack a well-define

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6818a86e9ccac7cecad05d654981de29
https://doi.org/10.1002/pmic.200401216