Výsledky vyhledávání - "Giovanna Mulas"

Akademický článek

Ontogenetic changes in the tyrosine hydroxylase immunoreactive preoptic area in the small-spotted catshark Scyliorhinus canicula (L., 1758) females: catecholaminergic involvement in sexual maturation

Autor: Riccardo Porceddu, Cristina Porcu, Giovanna Mulas, Saturnino Spiga, Maria Cristina Follesa

Publikováno v: Frontiers in Neuroanatomy, Vol 17 (2024)

IntroductionThe catecholaminergic component of the brain-pituitary-gonadal axis, which mediates the influence of external and internal stimuli on the central nervous system and gonad development in vertebrates, is largely unexplored in Chondrichthyes

Externí odkaz: https://doaj.org/article/77afc3dab9d84fec86913cd3d81d7cc6

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Akademický článek

Beneficial effects of curtailing immune susceptibility in an Alzheimer’s disease model

Autor: Giulia Di Benedetto, Chiara Burgaletto, Anna R. Carta, Salvatore Saccone, Laurence Lempereur, Giovanna Mulas, Carla Loreto, Renato Bernardini, Giuseppina Cantarella

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-17 (2019)

Abstract Background Currently, there are no effective therapeutic options for Alzheimer’s disease, the most common, multifactorial form of dementia, characterized by anomalous amyloid accumulation in the brain. Growing evidence points to neuroinfla

Externí odkaz: https://doaj.org/article/5b3d2f646b2345b58927556b6c14dce2

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Akademický článek

Changes in Dendritic Spine Morphology and Density of Granule Cells in the Olfactory Bulb of Anguilla anguilla (L., 1758): A Possible Way to Understand Orientation and Migratory Behavior

Autor: Riccardo Porceddu, Cinzia Podda, Giovanna Mulas, Francesco Palmas, Luca Picci, Claudia Scano, Saturnino Spiga, Andrea Sabatini

Publikováno v: Biology, Vol 11, Iss 8, p 1244 (2022)

Olfaction could represent a pivotal process involved in fish orientation and migration. The olfactory bulb can manage olfactive signals at the granular cell (GC) and dendritic spine levels for their synaptic plasticity properties and changing their m

Externí odkaz: https://doaj.org/article/b7f8955cf0ce4ae0bf1975e36f5d11b2

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Akademický článek

The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex

Autor: Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R. Carta

Publikováno v: Cells, Vol 11, Iss 17, p 2628 (2022)

Parkinson’s disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis in limbic and neocortica

Externí odkaz: https://doaj.org/article/3eedc67be715406cbd276027691c9ffd

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Akademický článek

Neuroprotection by the Immunomodulatory Drug Pomalidomide in the Drosophila LRRK2WD40 Genetic Model of Parkinson’s Disease

Autor: Maria Antonietta Casu, Ignazia Mocci, Raffaella Isola, Augusta Pisanu, Laura Boi, Giovanna Mulas, Nigel H. Greig, Maria Dolores Setzu, Anna R. Carta

Publikováno v: Frontiers in Aging Neuroscience, Vol 12 (2020)

The search for new disease-modifying drugs for Parkinson’s disease (PD) is a slow and highly expensive process, and the repurposing of drugs already approved for different medical indications is becoming a compelling alternative option for research

Externí odkaz: https://doaj.org/article/0fd9fc7c6a714725a54eba324e1c4037

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Akademický článek

Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

Autor: Augusta Pisanu, Daniela Lecca, Giovanna Mulas, Jadwiga Wardas, Gabriella Simbula, Saturnino Spiga, Anna R. Carta

Publikováno v: Neurobiology of Disease, Vol 71, Iss , Pp 280-291 (2014)

Neuroinflammatory changes play a pivotal role in the progression of Parkinson's disease (PD) pathogenesis. Recent findings have suggested that activated microglia may polarize similarly to peripheral macrophages in the central nervous system (CNS), a

Externí odkaz: https://doaj.org/article/26c53dd6b1084ddea4d92e08241c582c

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Akademický článek

Co-transplantation of endothelial progenitor cells and pancreatic islets to induce long-lasting normoglycemia in streptozotocin-treated diabetic rats.

Autor: Paola Quaranta, Sara Antonini, Saturnino Spiga, Benedetta Mazzanti, Michele Curcio, Giovanna Mulas, Marco Diana, Pasquina Marzola, Franco Mosca, Biancamaria Longoni

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94783 (2014)

Graft vascularization is a crucial step to obtain stable normoglycemia in pancreatic islet transplantation. Endothelial progenitor cells (EPCs) contribute to neoangiogenesis and to the revascularization process during ischaemic events and play a key

Externí odkaz: https://doaj.org/article/5fa293b12b62488290b1b0cea9a84b4f

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Immunomodulatory drugs alleviate l ‐dopa‐induced dyskinesia in a rat model of Parkinson's disease

Autor: Sandro Fenu, Saturnino Spiga, Nigel H. Greig, Augusta Pisanu, Ezio Carboni, Giovanna Mulas, Anna R. Carta, David Tweedie, Laura Boi, Michael T. Scerba

Publikováno v: Movement Disorders. 34:1818-1830

BACKGROUND Thalidomide and closely related analogues are used clinically for their immunomodulatory and antiangiogenic properties mediated by the inhibition of the proinflammatory cytokine tumor necrosis factor α. Neuroinflammation and angiogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88616b4ea9cc7ac6571d3192c198bf82
https://doi.org/10.1002/mds.27799

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Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

Autor: Ignazia Mocci, Elzbieta Janda, Anna R. Carta, Saturnino Spiga, Alfonso De Simone, Anna Ena, Maria Antonietta Casu, Maria Scherma, Augusta Pisanu, Ezio Carboni, Giovanna Mulas, Maria Francesca Palmas, Giuliana Fusco, Paola Fadda, Laura Boi, Valentina Satta

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8535, p 8535 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 22
International journal of molecular sciences
21 (2020): 1–25. doi:10.3390/ijms21228535
info:cnr-pdr/source/autori:Boi L.; Pisanu A.; Palmas M.F.; Fusco G.; Carboni E.; Casu M.A.; Satta V.; Scherma M.; Janda E.; Mocci I.; Mulas G.; Ena A.; Spiga S.; Fadda P.; De Simone A.; Carta A.R./titolo:Modeling Parkinson's disease neuropathology and symptoms by intranigral inoculation of preformed human ?-synuclein oligomers/doi:10.3390%2Fijms21228535/rivista:International journal of molecular sciences (Print)/anno:2020/pagina_da:1/pagina_a:25/intervallo_pagine:1–25/volume:21

The accumulation of aggregated &alpha
synuclein (&alpha
Syn) is a hallmark of Parkinson&rsquo
s disease (PD). Current evidence indicates that small soluble &alpha
Syn oligomers (&alpha
SynOs) are the most toxic species among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba27676096dba207ee0feca4bcf4ed2b
https://www.mdpi.com/1422-0067/21/22/8535

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