Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Giovanna Muggiolu"'
Autor:
Pierre Beaudier, Florent Vilotte, Marina Simon, Giovanna Muggiolu, Quentin Le Trequesser, Guillaume Devès, Laurent Plawinski, Antoine Mikael, Jérôme Caron, Guy Kantor, Denis Dupuy, Marie-Hélène Delville, Philippe Barberet, Hervé Seznec
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract This study aimed to explore the potential of metal oxides such as Titanate Scrolled Nanosheets (TNs) in improving the radiosensitivity of sarcoma cell lines. Enhancing the response of cancer cells to radiation therapy is crucial, and one pro
Externí odkaz:
https://doaj.org/article/fa497c2286134a3391162a73d03c8a69
Autor:
Xavier Tatin, Giovanna Muggiolu, Sarah Libert, David Béal, Thierry Maillet, Jean Breton, Sylvie Sauvaigo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The repair of DNA double-strand breaks (DSBs) involves interdependent molecular pathways, of which the choice is crucial for a cell’s fate when facing a damage. Growing evidence points toward the fact that DSB repair capacities correlate w
Externí odkaz:
https://doaj.org/article/8550e2bdcf484b77b8357d7ba3fe1595
Autor:
Liwang Liu, Marina Simon, Giovanna Muggiolu, Florent Vilotte, Mikael Antoine, Jerôme Caron, Guy Kantor, Philippe Barberet, Hervé Seznec, Bertrand Audoin
Publikováno v:
Photoacoustics, Vol 27, Iss , Pp 100385- (2022)
How DNA damage and repair processes affect the biomechanical properties of the nucleus interior remains unknown. Here, an opto-acoustic microscope based on time-domain Brillouin spectroscopy (TDBS) was used to investigate the induced regulation of in
Externí odkaz:
https://doaj.org/article/7f9c5cfe31254006976bdb4b628a0aa6
Autor:
Giovanna Muggiolu, Eva Torfeh, Marina Simon, Guillaume Devès, Hervé Seznec, Philippe Barberet
Publikováno v:
Biology, Vol 12, Iss 7, p 921 (2023)
Time-lapse fluorescence imaging coupled to micro-irradiation devices provides information on the kinetics of DNA repair protein accumulation, from a few seconds to several minutes after irradiation. Charged-particle microbeams are valuable tools for
Externí odkaz:
https://doaj.org/article/2ba752b5c3b34b848c5634764cc399be
Autor:
Pierre Philouze, Arnaud Gauthier, Alexandra Lauret, Céline Malesys, Giovanna Muggiolu, Sylvie Sauvaigo, Antoine Galmiche, Philippe Ceruse, Gersende Alphonse, Anne-Sophie Wozny, Claire Rodriguez-Lafrasse
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 877 (2022)
Squamous cell carcinoma is the most common type of head and neck cancer (HNSCC) with a disease-free survival at 3 years that does not exceed 30%. Biomarkers able to predict clinical outcomes are clearly needed. The purpose of this study was to invest
Externí odkaz:
https://doaj.org/article/75246cbeed00412095b89786d517030b
Autor:
Sylvie Sauvaigo, Giovanna Muggiolu, Sarah Libert, Bertrand Treillard, Gersende Alphonse, Christian A. Righini, Philippe Ceruse, Pierre Philouze, Claire Rodriguez-Lafrasse
Publikováno v:
Cancer Research. 82:3493-3493
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. It is often associated with a history of smoking/alcohol consumption or exposure to the human papilloma virus (HPV). Beyond surgery, treatment usually includes DNA d
Autor:
Giovanna Muggiolu, Adam Stewart, Udai Banerji, Florence I. Raynaud, Albert Hallsworth, Lisa Pickard, Sylvie Sauvaigo
Publikováno v:
Cancer Research. 81:1010-1010
Purpose of study: CHK1 and WEE1 are critical determinants of the G2/M cell cycle checkpoint. The G2/M checkpoint is crucial to enable DNA repair caused by endogenous and exogenous stress. We hypothesised that simultaneous inhibition of CHK1 and WEE1
Autor:
Libert Libert, Claire Rodriguez-Lafrasse, Nicolas Magné, Sylvie Sauvaigo, Giovanna Muggiolu, Thierry Maillet, Elisabeth Daguenet
Publikováno v:
Cancer Research. 81:680-680
Introduction: About 50% of patients with solid tumors receive radiotherapy (RT) which induces cancer cells death through radiation-induced DNA damage. Five to 10% of these patients experience severe toxicity that can heavily impact their quality of l
Autor:
Claire Rodriguez-Lafrasse, Elisabeth Daguenet, Thierry Maillet, Sylvie Sauvaigo, Giovanna Muggiolu, Sarah Libert, Nicolas Magné
Publikováno v:
Cancer Research. 81:681-681
Introduction: Radiotherapy (RT) can induce with short-term (acute) and long term toxicity. Although acute toxicity is generally well tolerated, long term toxicity might be irreversible and progressive over time. RT induces damage in healthy tissue, t
Publikováno v:
Mutation Research/Reviews in Mutation Research. 788:108388
DNA double-strand breaks (DSBs) are highly deleterious lesions, responsible for mutagenesis , chromosomal translocation or cell death. DSB repair (DSBR) is therefore a critical part of the DNA damage response (DDR) to restore molecular and genomic in