Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Giovanna Misuraca"'
Publikováno v:
Scopus-Elsevier
The skin depigmenting agent hydroquinone (HQ) is shown to inhibit melanogenesis in vitro by acting as an alternate substrate of tyrosinase and preventing conversion of tyrosine to melanin. Upon the action of tyrosinase, and in the presence of catalyt
Autor:
Sofia Memoli, Anna Palumbo, Giuseppe Prota, Giovanna Misuraca, Marco d'Ischia, Alessandra Napolitano
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1346:61-68
Although it has long been known that epidermal melanocytes produce and excrete a number of melanin-related metabolites, including 5.6-dihydroxyindole (DHI), 5,6-dihydroxyindole-2-carboxylic acid (DHICA), and 5-S-cysteinyldopa (CD), the possible funct
Autor:
Ferdinand Lejeune, R Morandini, Giuseppe Prota, D. Mascagna, Marco d'Ischia, Giovanna Misuraca, Ghanem Elias Ghanem
Publikováno v:
Melanoma Research. 2:25-32
New tyrosinase-targeted compounds based on structural variants of the prototype unit 4-aminophenol have been synthesized and screened for their potential as antitumour agents against malignant melanoma. Cytotoxicity assays showed that N-4-hydroxyphen
Autor:
Anna Palumbo, Jose C. Garcia Borron, José Ángel Castillo Lozano, Giovanna Misuraca, Pilar Aroca, Francisco Solano, Giuseppe Prota
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1115:1-5
A vis-a-vis comparison between the effects of dopachrome tautomerase (DCT) and metal ions, e.g., cupric ions, on the kinetics and mode of rearrangement of dopachrome has been carried out under appropriate analytical conditions. The enzyme-promoted re
Autor:
Alessandro Pezzella, Giovanna Misuraca, Marco d'Ischia, Giuseppe Prota, Alessandra Napolitano
Exposure of dopamine to an excess of linoleic acid 13-hydroperoxide (13-hydroperoxyoctadecadienoic acid) in the presence of ferrous ions in Tris buffer, pH 7.4, resulted in a relatively fast, oxygen-independent reaction exhibiting first-order kinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa7f5f61bb6406650c9bdbc04aa7bc7
http://hdl.handle.net/11588/142210
http://hdl.handle.net/11588/142210
Kinetic experiments are reported showing that mammalian tyrosinase from B16 mouse melanoma is significantly activated by catalytic amounts of ferrous ions. Monitoring of tyrosine oxidation by both dopachrome formation and oxygen consumption showed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8284b79be4f7fcb426aec99c2367c202
https://hdl.handle.net/11384/83998
https://hdl.handle.net/11384/83998
L-DOPA remains the mainstay of therapy for Parkinson's disease (PD). However, the side-effects assocd. with its chronic use have fuelled the search for novel strategies as an alternative to simply supplementing dopamine deficiency. In reviewing with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a78719e536edce7c7323e18b08f8f23
http://hdl.handle.net/11588/365486
http://hdl.handle.net/11588/365486
The mechanism of formation of 5-S-cysteinyldopamine (5-S-CDA), a putative index of oxidative stress in dopaminergic regions of the brain, was investigated by comparing the ability of a number of neurochemically relevant oxidising systems to promote t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b152da3aafe7ba38013c57aa1a19af
http://hdl.handle.net/11588/142225
http://hdl.handle.net/11588/142225
Pre-incubation of J774 murine macrophages with 5,6-dihydroxyindole-2-carboxylic acid (DHICA), a diffusible intermediate in the biosynthesis of eumelanins, leads to a marked increase in the levels of nitric oxide (NO) produced by lipopolysaccharide (L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6102237562341831b8606e4321f08cbb
http://hdl.handle.net/11588/458064
http://hdl.handle.net/11588/458064
A possible role of melanin precursors in lipid peroxidation was investigated using the lipoxygenase catalysed oxygenation of arachidonic acid (AA) as a model system. Polarographical monitoring of oxygen consumption showed that, among the metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158ca9458a3a8c9ae252c517ab6ae633
http://hdl.handle.net/11588/154423
http://hdl.handle.net/11588/154423