Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment.

Autor: Giovanna M Collu, Andreas Jenny, Konstantin Gaengel, Ivana Mirkovic, Mei-Ling Chin, Ursula Weber, Michael J Smith, Marek Mlodzik

Publikováno v: PLoS Genetics, Vol 14, Iss 5, p e1007391 (2018)

Planar cell polarity (PCP) instructs tissue patterning in a wide range of organisms from fruit flies to humans. PCP signaling coordinates cell behavior across tissues and is integrated by cells to couple cell fate identity with position in a developi

Externí odkaz: https://doaj.org/article/93aea9fa33fc452caf5af3271c618def

Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia

Autor: Rebecca Williams, Stephanie Jobling, Andrew H. Sims, Chunyan Mou, Lorna Wilkinson, Giovanna M. Collu, Charles H. Streuli, Andrew P. Gilmore, Denis J. Headon, Keith Brennan

Publikováno v: Williams, R, Jobling, S, Sims, A H, Mou, C, Wilkinson, L, Collu, G M, Streuli, C H, Gilmore, A P, Headon, D J & Brennan, K 2021, ' Elevated EDAR signalling promotes mammary gland tumourigenesis with squamous metaplasia ', Oncogene . https://doi.org/10.1038/s41388-021-01902-6

Ectodysplasin A receptor (EDAR) is a death receptor in the Tumour Necrosis Factor Receptor (TNFR) superfamily with roles in the development of hair follicles, teeth and cutaneous glands. Here we report that human Oestrogen Receptor (ER) negative brea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a194eb2099742e6123e1543b9d9df3
https://doi.org/10.1038/s41388-021-01902-6

Par3/Bazooka promotes Notch pathway target gene activation

Autor: Jun Wu, Neeta Bala Tannan, Linh T. Vuong, Yildiz Koca, Giovanna M. Collu, Marek Mlodzik

The conserved bazooka (baz/par3) gene acts as a key regulator of asymmetrical cell divisions across the animal kingdom. The associated Par3/Baz-Par6-aPKC protein complex is also well known for its conserved role in the establishment of apical/basal c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ac2216c964f248ae72a798d51245af7
https://doi.org/10.1101/2022.05.24.493322

Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation

Autor: Marek Mlodzik, Reza Farhadifar, Nabila Founounou, Michael Shelley, Giovanna M. Collu, Ursula Weber

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications

The phenomenon of tissue fluidity—cells’ ability to rearrange relative to each other in confluent tissues—has been linked to several morphogenetic processes and diseases, yet few molecular regulators of tissue fluidity are known. Ommatidial rot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de08bace9f17ccc31318ca99ac33d58f
https://doi.org/10.1038/s41467-021-27253-0

Abstract A08: Genetic drug resistance screen identifies LZTR1 as regulator of RAS ubiquitination and signaling

Autor: Gregory I. Vladimer, Vincent A. Blomen, Georg E. Winter, Vitaly Sedlyarov, Felix Kartnig, Giovanna M. Collu, Melanie Pieraks, Manuele Rebsamen, Thijn R. Brummelkamp, Katja Parapatics, Astrid Fauster, Fiorella Schischlik, Johannes W. Bigenzahn, Leonhard X. Heinz, André C. Müller, Robert Kralovics, Giulio Superti-Furga, Marek Mlodzik

Publikováno v: Molecular Cancer Research. 18:A08-A08

Small-molecule tyrosine kinase inhibitor (TKI)-based treatment of chronic myeloid leukemia (CML), directed by the presence of the Philadelphia chromosome (Ph+) encoded BCR-ABL tyrosine kinase, is a paradigm of targeted cancer therapy. However, the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49e7c1d4a1d3b714fafb2de751c1a0f1
https://doi.org/10.1158/1557-3125.ras18-a08