Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Giovanna Gualtieri"'
Autor:
John Morser, Imadul Islam, Cornell Mallari, Elena Ho, Marc Adler, Kumar Emayan, Gary Phillips, Shendong Yuan, Marc Whitlow, Christopher W. West, David R. Light, Giovanna Gualtieri, Drew Sukovich, Ulrich Bothe, Zheng Chang, Kieu Chu, Judi Bryant, Deborah Chen, Caralee Schaefer, Brad O. Buckman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3372-3375
We report here the design and synthesis of a novel series of benzylamines that are potent and selective inhibitors of uPA with promising oral availability in rat. Further evaluation of one representative (ZK824859) of the new structural class showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b761e7a2ae7d063c07c5d293801b02
https://doi.org/10.1016/j.bmcl.2018.09.001
https://doi.org/10.1016/j.bmcl.2018.09.001
Autor:
Dennis P. Curran, Giovanna Gualtieri
Publikováno v:
Synlett. 2001:1038-1041
Two members of a new class of dithiogermanium hydrides have been prepared in racemic and enantiopure form. Reaction of 2,2′-dithiobinap and 3,3′-bis-trimethylsilyl-2,2′-dithiobinap with tBuGeCl3 followed by reduction provides the corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce1364c9e0e4d6bd88e8f69506b8f2e
https://doi.org/10.1055/s-2001-14655
https://doi.org/10.1055/s-2001-14655
Autor:
Gary Phillips, Rebecca Pulk, Christopher W. West, Danny Arnaiz, Shendong Yuan, Kieu Chu, Marc Adler, David R. Light, Deborah Chen, Elena Ho, Giovanna Gualtieri, Marc Whitlow, Christoph Huwe, Judi Bryant, Drew Sukovich
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
In this Letter we report the synthesis and evaluation of a series of non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Starting from compound 1, a significant change provided compounds in which the amidine, binding in the S1 pocket, wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60747fc1bc1095b1d652f959205693a8
https://pubmed.ncbi.nlm.nih.gov/19703768
https://pubmed.ncbi.nlm.nih.gov/19703768
Autor:
Eric R. Prossnitz, Mithra Mahmoudi, William J. Karpus, Richard Horuk, Stewart Leung, Eric Blasko, Megan K. Dennis, Meredith Halks-Miller, Giovanna Gualtieri, Christopher A. Haskell
Publikováno v:
Journal of neuroimmunology. 214(1-2)
The beneficial effects of estrogens in multiple sclerosis are thought to be mediated exclusively by the classical nuclear estrogen receptors ERalpha and ERbeta. However, recently many reports revealed that estrogens are able to mediate rapid signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccff8ca2cb87a8c9225964481833eccc
https://pubmed.ncbi.nlm.nih.gov/19664827
https://pubmed.ncbi.nlm.nih.gov/19664827
Publikováno v:
ChemInform. 34
A new class of dithiostannanes and dithiogermanes have been prepared from 1,1'-binaphthyl-2,2'-dithiol and 3,3'-bis(trimethylsilyl)-1,1'-binaphtho-2,2'-dithiol. While reduction of 4-butyl-4-chloro-3,5-dithia-4-stanna-cyclohepta[2,1-a;3,4-a']dinaphtha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecac844426c28825a7126421e6364093
https://doi.org/10.1002/chin.200342180
https://doi.org/10.1002/chin.200342180
Publikováno v:
The Journal of organic chemistry. 68(13)
A new class of dithiostannanes and dithiogermanes have been prepared from 1,1'-binaphthyl-2,2'-dithiol and 3,3'-bis(trimethylsilyl)-1,1'-binaphtho-2,2'-dithiol. While reduction of 4-butyl-4-chloro-3,5-dithia-4-stanna-cyclohepta[2,1-a;3,4-a']dinaphtha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ee26121283ff207c6faa0a14875589
https://pubmed.ncbi.nlm.nih.gov/12816453
https://pubmed.ncbi.nlm.nih.gov/12816453