Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation.

Autor: Pedro J Gomez-Pinilla, Giovanna Farro, Martina Di Giovangiulio, Nathalie Stakenborg, Andrea Némethova, Annick de Vries, Adrian Liston, Thorsten B Feyerabend, Hans-Reimer Rodewald, Guy E Boeckxstaens, Gianluca Matteoli

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85304 (2014)

INTRODUCTION: Intestinal manipulation (IM) during abdominal surgery results in intestinal inflammation leading to hypomotility or ileus. Mast cell activation is thought to play a crucial role in the pathophysiology of postoperative ileus (POI). Howev

Externí odkaz: https://doaj.org/article/66fd3e2ec9e946bebf635b90d4b29638

The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus.

Autor: Léa M M Costes, Jan van der Vliet, Giovanna Farro, Gianluca Matteoli, Sjoerd H W van Bree, Brenda J Olivier, Martijn A Nolte, Guy E Boeckxstaens, Cathy Cailotto

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102211 (2014)

Postoperative ileus is characterized by a transient impairment of the gastrointestinal motility after abdominal surgery. The intestinal inflammation, triggered by handling of the intestine, is the main factor responsible for the prolonged dysmotility

Externí odkaz: https://doaj.org/article/9108a0fda1ef449aa68e087e8af1cca8

Vagotomy Affects the Development of Oral Tolerance and Increases Susceptibility to Develop Colitis Independently of α-7 Nicotinic Receptor

Autor: Gianluca Matteoli, Goele Bosmans, Nathalie Stakenborg, Pedro J. Gomez-Pinilla, Elisa Meroni, Morgane Florens, Martina Di Giovangiulio, Guy E. Boeckxstaens, Giovanna Farro

Publikováno v: Molecular Medicine, Vol 22, Iss 1, Pp 464-476 (2016)

Vagotomy (VGX) increases the susceptibility to develop colitis suggesting a crucial role for the cholinergic anti-inflammatory pathway in the regulation of the immune responses. Since oral tolerance and the generation of regulatory T cells (Tregs) ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea13b94a5793cfe60965bbc1526b7e4
http://link.springer.com/article/10.2119/molmed.2016.00062

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus

Autor: Jo A. Van Ginderachter, Michelle Stakenborg, Gianluca Matteoli, Pedro J. Gomez-Pinilla, Evelien Labeeuw, Damya Laoui, Elisa Meroni, Kristin A. Sauter, Martina Di Giovangiulio, Francesca D'Errico, Gera Goverse, Yvon Elkrim, Giovanna Farro, Zofia M. Lisowski, Nathalie Stakenborg, David A. Hume, Guy E. Boeckxstaens

Publikováno v: Farro, G, Stakenborg, M, Gomez-Pinilla, P J, Labeeuw, E, Goverse, G, Giovangiulio, M D, Stakenborg, N, Meroni, E, D'Errico, F, Elkrim, Y, Laoui, D, Lisowski, Z, Sauter, K A, Hume, D A, Van Ginderachter, J A, Boeckxstaens, G E & Matteoli, G 2017, ' CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus ', Gut, vol. 66, no. 12, pp. 2098-2109 . https://doi.org/10.1136/gutjnl-2016-313144

ObjectivePostoperative ileus (POI) is assumed to result from myeloid cells infiltrating the intestinalmuscularis externa(ME) in patients undergoing abdominal surgery. In the current study, we investigated the role of infiltrating monocytes in a murin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0272ab7501966dc27f2a23e2d30bfb
https://www.pure.ed.ac.uk/ws/files/40021097/R1_GUT_submitted_files_24_02_2017.pdf

Inhibition of spleen tyrosine kinase as treatment of postoperative ileus

Autor: Kevin Lee, Pedro J. Gomez-Pinilla, Cesar Ramirez-Molina, Fleur Suzanne van de Bovenkamp, Michael J. Skynner, Wouter J de Jonge, Sjoerd H. van Bree, Martina Di Giovangiulio, Cathy Cailotto, Dave Lugo, Andrea Nemethova, G. E. E. Boeckxstaens, Giovanna Farro, Gianluca Matteoli

Publikováno v: Gut, 62(11), 1581-1590. BMJ Publishing Group

OBJECTIVE: Intestinal inflammation resulting from manipulation-induced mast cell activation is a crucial mechanism in the pathophysiology of postoperative ileus (POI). Recently it has been shown that spleen tyrosine kinase (Syk) is involved in mast c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e144beff2a1e43249d02ba52b27778d1
https://doi.org/10.1136/gutjnl-2012-302615