Výsledky vyhledávání - "Giovanna Certo"

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments

Autor: Ayelet Fishman, Serena Vittorio, Batel Deri, Rosaria Gitto, Laura Ielo, Antonio Rapisarda, Maria Paola Germanò, Maria Rosa Buemi, Stefania Ferro, Yael Pazy, Giovanna Certo, Laura De Luca

Publikováno v: Journal of Medicinal Chemistry. 61:3908-3917

The inhibition of tyrosinase (Ty, EC 1.14.18.1) represents an efficient strategy of decreasing melanogenesis and skin hyperpigmentation. A combination of crystallographic and docking studies on two different tyrosinases, that from Bacillus megaterium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdab769382b81b1fcb25c1c1ae23ddd
https://doi.org/10.1021/acs.jmedchem.7b01745

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Anti-angiogenic activity and phytochemical screening of fruit fractions from Vitex agnus castus

Autor: Rosaria Costa, Ambrogina Albergamo, Giacomo Dugo, Giovanna Certo, Maria Paola Germanò, Valeria D'Angelo, Marina Russo

Although the antitumour activity of Vitex agnus castus fruits has been already addressed, no work has yet assessed their anti-angiogenic potential. To this purpose, several extractive fractions of such fruits were tested on zebrafish embrios by EAP a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2125704b7e5e25b09c1e3d05e31269d5
http://hdl.handle.net/11570/3105539

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Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors

Autor: Ayelet Fishman, Laura De Luca, Rosaria Gitto, Giovanna Certo, M. Kanteev, Antonio Rapisarda, Maria Rosa Buemi, Stefania Ferro, Laura Ielo, Maria Paola Germanò

Tyrosinase is involved in the production of melanin through the hydroxylation of monophenols to o -diphenols. The role of this enzyme was extensively studied in order to identify new therapeutics preventing skin pigmentation and melanoma. In this wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c200c875742b706b47f781f0311517d8
http://hdl.handle.net/2318/1835451

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Searching for indole derivatives as potential mushroom tyrosinase inhibitors

Autor: Giovanna Certo, Rosaria Gitto, Antonio Rapisarda, Stefania Ferro, Laura De Luca, Maria Paola Germanò

Tyrosinase is a copper-containing enzyme widely distributed in nature, involved in the biosynthesis of melanin whose role is to protect the skin from ultraviolet damage. A great interest has been shown on the melanin involvement in malignant melanoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb03cd4039588f60e8551a7e5e88dd3
http://hdl.handle.net/11570/3091195

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Phytochemical screening of Artemisia arborescens L. by means of advanced chromatographic techniques for identification of health-promoting compounds

Autor: Maria Paola Germanò, Marina Russo, Giovanna Certo, Elisa Grasso, Rosaria Costa, Flavio A. Franchina, Luigi Mondello, Salvatore Ragusa, Antonio Zanotto

Publikováno v: Journal of pharmaceutical and biomedical analysis. 117

Artemisia arborescens, also known as tree wormwood, is a typical species of the Mediterranean flora. It has been used in folk medicine for its antispasmodic, anti-pyretic, anti-inflammatory, and abortifacient properties. In the current study, the app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f343fd945edbc404e3478ed99b9e0e
https://pubmed.ncbi.nlm.nih.gov/26476295

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Anti-angiogenic activity of Entada africana root

Autor: Nunziatina De Tommasi, Maria Paola Germanò, Antonio Rapisarda, Giovanna Certo, Rokia Sanogo, Valeria D'Angelo, Nicola Malafronte

Entada africana roots are used in African traditional medicine for various diseases including inflammation. This application may be mediated through anti-angiogenic effects. Thus, in this study the anti-angiogenic activity of E. africana root extract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551fc15e9a8d92b006468e8797405a40

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Chemical Composition ofJuniperus PhoeniceaandJ. DrupaceaEssential Oils and their Biological Effects in the Choriallantoic Membrane (CAM) Assay

Autor: Giovanna Certo, Aikaterini Koutsaviti, Enza Maria Galati, Maria Paola Germanò, Olga Tzakou

Publikováno v: Natural Product Communications. 12:1934578X1701200

The aim of the present study was the chemical analysis of the essential oils from Juniperus phoenicea and J. drupacea female cones and evaluation of their biological effects. Fresh samples, collected in Greece, were subjected separately to hydrodisti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc594453e2a921953d3393bf3146e117
https://doi.org/10.1177/1934578x1701200336

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Betula pendula Roth leaves: gastroprotective effects of an HPLC fingerprinted methanolic extract

Autor: Francesco Cacciola, Paola Dugo, Maria Paola Germanò, Luigi Mondello, Giovanna Certo, Antonio Rapisarda, Valeria D'Angelo, Paola Donato

In this study, a methanolic extract of Betula pendula leaves (BLE) was investigated for its gastroprotective effects against 90% ethanol-induced ulcer in rats. Oral pretreatment of rats with BLE (100, 200 and 400 mg kg(- 1)) significantly reduced the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3478e48c3490b2faa31e8c43790fa4
http://hdl.handle.net/11570/2431636

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Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities

Autor: Nunziatina De Tommasi, Fabrizio Dal Piaz, Giovanna Certo, Rokia Sanogo, M. Pesca, Antonio Rapisarda, Maria Paola Germanò, Antonio Vassallo, Sandro De Falco, Alessandra Braca, Maryan Bruzual De Abreu

Publikováno v: Journal of natural products
76(1 (2013): 29–35. doi:10.1021/np300614u
info:cnr-pdr/source/autori:Pesca MS, Dal Piaz F, Sanogo R, Vassallo A, Bruzual de Abreu M, Rapisarda A, Germanò MP, Certo G, De Falco S, De Tommasi N, Braca A./titolo:Bioassay-Guided Isolation of Proanthocyanidins with Antiangiogenic Activities./doi:10.1021%2Fnp300614u/rivista:Journal of natural products (Print)/anno:2013/pagina_da:29/pagina_a:35/intervallo_pagine:29–35/volume:76(1

The proangiogenic members of the vascular endothelial growth factor (VEGF) family and related receptors play a central role in the modulation of pathological angiogenesis. In order to identify plant compounds able to interfere in the VEGFs/VEGFR-1 (F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8637a245f919f4681c4e0bccfeeb1597
http://hdl.handle.net/11570/2517024

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