Quantitative Structure-Activity Relationship Studies for Potential Rho-Associated Protein Kinase Inhibitors

Autor: Giovanna Cardoso Gajo, Tamiris Maria de Assis, Letícia Cristina Assis, Teodorico Castro Ramalho, Elaine Fontes Ferreira da Cunha

Publikováno v: Journal of Chemistry, Vol 2016 (2016)

A series of pyridylthiazole derivatives developed by Lawrence et al. as Rho-associated protein kinase inhibitors were subjected to four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis. The models were generated applying ge

Externí odkaz: https://doaj.org/article/55adae017bf2476d8aa39dcf2aef3a32

QSPR Models of β-dihydroagarofuran Derivatives

Autor: Teodorico C. Ramalho, Letícia Santos-Garcia, Tamiris Maria de Assis, Daniela Rodrigues Silva, Letícia C. Assis, Elaine F. F. da Cunha, Giovanna Cardoso Gajo

Publikováno v: International Journal of Quantitative Structure-Property Relationships. 2:1-15

The use of chemical pesticides, although the most effective method for controlling insects, may in the long-term result in pest resistance development as well as it may impact on food quality, the environment and human health. Therefore, the botanica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e05c12280b8405619f421343df277167
https://doi.org/10.4018/ijqspr.2017070101

Purification and identification of metabolites produced by Bacillus cereus and B. subtilis active against Meloidogyne exigua, and their in silico interaction with a putative phosphoribosyltransferase fromM. incognita

Autor: Helvécio M. Santos Júnior, Giovanna Cardoso Gajo, Alexandro S. Nunes, Vicente Paulo Campos, Renata S.C. De Pinho, Denilson F. Oliveira

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 86, Iss 2, Pp 525-538 (2014)
Anais da Academia Brasileira de Ciências v.86 n.2 2014
Anais da Academia Brasileira de Ciências
Academia Brasileira de Ciências (ABC)
instacron:ABC
Anais da Academia Brasileira de Ciências, Volume: 86, Issue: 2, Pages: 525-538, Published: 25 APR 2014

To contribute to the development of products to controlMeloidogyne exigua, the bacteria Bacillus cereus and B. subtilis were cultivated in liquid medium to produce metabolites active against this plant-parasitic nematode. Fractionation of the crude d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f738d22324644f5a997a8560e1e5862b
https://doi.org/10.1590/0001-3765201402412

Multi-objective Optimization of Benzamide Derivatives as Rho Kinase Inhibitors

Autor: Elaine F. F. da Cunha, Giovanna Cardoso Gajo, Stephen J. Barigye, Daniela Rodrigues Silva

Publikováno v: Molecular Informatics. 37:1700080

Despite recent advances in Computer Aided Drug Discovery and High Throughput Screening, the attrition rates of drug candidates continue to be high, underscoring the inherent complexity of the drug discovery paradigm. Indeed, a compromise between seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d686d76fe6d467fe937a66b983f59d12
https://doi.org/10.1002/minf.201700080