Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines

Autor: Viviane A. O. Silva, Marcela N. Rosa, Izabela N. F. Gomes, Patrik da Silva Vital, Ana Laura V. Alves, Adriane F. Evangelista, Giovanna B. Longato, Adriana C. Carloni, Bruno G. Oliveira, Fernanda E. Pinto, Wanderson Romão, Allisson R. Rezende, Arali A. C. Araújo, Lohanna S. F. M. Oliveira, Alessandra A. M. Souza, Stephanie C. Oliveira, Rosy Iara Maciel A. Ribeiro, Rui M. Reis

Publikováno v: Molecules, Vol 28, Iss 3, p 1394 (2023)

(1) Background: Malignant gliomas are aggressive tumors characterized by fast cellular growth and highly invasive properties. Despite all biological and clinical advances in therapy, the standard treatment remains essentially palliative. Therefore, s

Externí odkaz: https://doaj.org/article/64747186f25a4148bf6bed48e20b8991

Synthesis, Selective Cytotoxic Activity against Human Breast Cancer MCF7 Cell Line and Molecular Docking of Some Chalcone-Dihydropyrimidone Hybrids

Autor: Eduardo B. Mass, Carolina A. de Lima, Marcelo G. M. D’Oca, Juliana M. Sciani, Giovanna B. Longato, Dennis Russowsky

Publikováno v: Drugs and Drug Candidates; Volume 1; Issue 1; Pages: 3-21

Designed Chalcone-Dihydropyrimidinone hybrid compounds were synthesized expeditiously. The hybridization was performed through the Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) from the propargyloxy chalcones and azido-dihydropyrimidinones. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb494afe3f84eafa93f303aefbc32ce
https://doi.org/10.3390/ddc1010002

Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron’s Connection: A Possible Neuroprotector Effect

Autor: Giovanna B. Longato, Vanessa Zambelli, Rodinei Vieira Veloso, Gian Lucas M Arruda, Antonio C. Marques, Yara Cury, Juliana Mozer Sciani, Hugo Vigerelli, Michelle Cristiane Bufalo, Gisele Picolo, André C. Morandini

Publikováno v: BioMed Research International, Vol 2021 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BioMed Research International

Neurodegenerative diseases are one of the major causes of death worldwide, characterized by neurite atrophy, neuron apoptosis, and synapse loss. No effective treatment has been indicated for such diseases so far, and the search for new drugs is being

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae44e45d8443ee3eaab62b2761cb654
https://doi.org/10.1155/2021/8855248

Investigation of U-251 cell death triggered by flavonoid luteolin: towards a better understanding on its anticancer property against glioblastomas

Autor: Cláudia Quintino da Rocha, Marcela N. Rosa, Yollanda Edwirges Moreira Franco, Jessyane R. do Nascimento, Patrícia de Oliveira Carvalho, Viviane Aline Oliveira Silva, Denise Gonçalves Priolli, Carolina Afonso de Lima, Giovanna B. Longato, Rui Manuel Reis

Publikováno v: Natural Product Research. 35:4807-4813

Recently, many studies have reported the anticancer properties of flavonoid luteolin against a variety of tumors, but there is still a lack in the description of its mechanism of action. In attempt to better contribute to the literature, we evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5a2941cf15ec11121502acd37078c2
https://doi.org/10.1080/14786419.2020.1727470

Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity

Autor: Kachi R. Kishore Kumar Reddy, Giovanna B. Longato, João E. de Carvalho, Ana L. T. G. Ruiz, Luiz F. Silva, Jr.

Publikováno v: Molecules, Vol 17, Iss 8, Pp 9621-9630 (2012)

An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investi

Externí odkaz: https://doaj.org/article/9484a12b3f8e4f00be0cef79a09d5e5d