Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Giovanna Pescatore"'
Autor:
Fabrizio Fiore, Michael Rowley, Philip Jones, Odalys Gonzalez Paz, Massimiliano Fonsi, Edith Monteagudo, Olaf Kinzel, Carsten Schultz-Fademrecht, Christian Steinkühler, Giovanna Pescatore, Laura Llauger-Bufi
Publikováno v:
Journal of Medicinal Chemistry. 52:3453-3456
The optimization of a potent, class I selective ketone HDAC inhibitor is shown. It possesses optimized pharmacokinetic properties in preclinical species, has a clean off-target profile, and is negative in a microbial mutagenicity (Ames) test. In a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcfe67490c8eaffda7f94edfef89fdb
https://doi.org/10.1021/jm9004303
https://doi.org/10.1021/jm9004303
Autor:
Christian Steinkühler, Fabrizio Fiore, Olaf Kinzel, Barbara Attenni, Sergio Serafini, Giovanna Pescatore, Ottavia Cecchetti, Carsten Schultz-Fademrecht, Massimiliano Fonsi, Michael Rowley, Philip Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5528-5532
Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy and the first generation HDAC inhibitors are currently in the clinic. Herein we describe the optimization of a series of ketone small molecule HDAC inhibitors leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7255cd3852dc10a6876068326211ba0e
https://doi.org/10.1016/j.bmcl.2008.09.003
https://doi.org/10.1016/j.bmcl.2008.09.003
Publikováno v:
Tetrahedron Letters. 44:6999-7002
Peptidic aminopeptidase inhibitors, bestatin, phebestin and probestin have been prepared by stereo- and regiocontrolled reactions from a common α,β-epoxy ester precursor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c3894685fd22ae98ed8572330ea8bb
https://doi.org/10.1016/s0040-4039(03)01799-4
https://doi.org/10.1016/s0040-4039(03)01799-4
Publikováno v:
Tetrahedron. 57:5649-5656
The results obtained in the MgBr2-mediated opening of 2,3-bifunctionalized epoxides are reported. The studies showed that the chelation control of MgBr2 between different functionalities can in some cases be selective.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4687bb635e29fc1f81bf6bf867d5b22a
https://doi.org/10.1016/s0040-4020(01)00492-6
https://doi.org/10.1016/s0040-4020(01)00492-6
Autor:
Giovanna Pescatore, et al. et al.
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656956c793edb86bf202a46b64fb43df
https://doi.org/10.1002/chin.201037163
https://doi.org/10.1002/chin.201037163
Publikováno v:
ChemInform. 32
The results obtained in the MgBr2-mediated opening of 2,3-bifunctionalized epoxides are reported. The studies showed that the chelation control of MgBr2 between different functionalities can in some cases be selective.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db3602b396324f8240bdd4034e166672
https://doi.org/10.1002/chin.200142061
https://doi.org/10.1002/chin.200142061
Autor:
Carlo Toniatti, Fabrizio Fiore, Philip Jones, Laura Llauger Bufi, Danila Branca, Olaf Kinzel, Michael Rowley, Giovanna Pescatore, Caterina Torrisi, Ester Muraglia, Federica Orvieto
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
Herein we describe the discovery of a novel series of pyrrolo[1,2-a]pyrazin-1(2H)-one PARP inhibitors. Optimization led to compounds that display excellent PARP-1 enzyme potency and inhibit the proliferation of BRCA deficient cells in the low double-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182f0fe062b9f1e8432d7af1fa595892
https://pubmed.ncbi.nlm.nih.gov/20031401
https://pubmed.ncbi.nlm.nih.gov/20031401
Autor:
Giovanna Pescatore, Samuele Lillini, Caterina Torrisi, Olaf Kinzel, Philip Jones, Costanza Bergami, Laura Llauger
Publikováno v:
ChemInform. 40
Functionalized fused heteroaryl pyrazinones were built up through a novel DBU-catalyzed intramolecular hydroamination reaction of aryl(prop-2-yn-1-yl)-1 H -heteroaryl-2-carboxamides. The nucleophilic addition afforded three isomers; two with an exo -
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fcdab5354281e38da364be5eac1253b
https://doi.org/10.1002/chin.200915172
https://doi.org/10.1002/chin.200915172
Autor:
Olaf Kinzel, Edith Monteagudo, Michael Rowley, Sergio Altamura, Odalys Gonzalez Paz, Raffaele De Francesco, Giovanna Pescatore, Philip Jones, Christian Steinkühler, Giuseppe Mesiti, Maria Verdirame
Publikováno v:
Journal of medicinal chemistry. 51(8)
Histone deacetylase (HDAC) inhibitors offer a promising strategy for cancer therapy, and the first generation HDAC inhibitors are currently in the clinic. Entirely novel ketone HDAC inhibitors have been developed from the cyclic tetrapeptide apicidin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36eca7a92c707ed4647d308a326962b
https://pubmed.ncbi.nlm.nih.gov/18370373
https://pubmed.ncbi.nlm.nih.gov/18370373
Autor:
Olaf Kinzel, Laura Llauger-Bufi, Giovanna Pescatore, Michael Rowley, Carsten Schultz-Fademrecht, Edith Monteagudo, Massimiliano Fonsi, Odalys Gonzalez Paz, Fabrizio Fiore, Christian Steinkühler, Philip Jones
Publikováno v:
Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 11, p3453-3456, 4p