Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Giovanna, Scapin"'
Autor:
Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models. Targeted protein degradation ha
Externí odkaz:
https://doaj.org/article/1f2680b79836478cba894b08e1a585a6
Autor:
Nhi L. Tran, Skerdi Senko, Kyle W. Lucier, Ashlyn C. Farwell, Sabrina M. Silva, Phat V. Dip, Nicole Poweleit, Giovanna Scapin, Claudio Catalano
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4528 (2024)
Membrane proteins constitute about 20% of the human proteome and play crucial roles in cellular functions. However, a complete understanding of their structure and function is limited by their hydrophobic nature, which poses significant challenges in
Externí odkaz:
https://doaj.org/article/ec8c4682b1874cbebedbfe50a2da50e2
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d6d3fdb3039843b9b530ac94e6eb34d2
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of
Externí odkaz:
https://doaj.org/article/12bfc20a079d44f5b507280558359df6
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of thes
Externí odkaz:
https://doaj.org/article/fbf41ee3e220482a9ea5fcab675f2be6
Autor:
Jessica F. Bruhn, Giovanna Scapin, Anchi Cheng, Brandon Q. Mercado, David G. Waterman, Thejusvi Ganesh, Sargis Dallakyan, Brandon N. Read, Travis Nieusma, Kyle W. Lucier, Megan L. Mayer, Nicole J. Chiang, Nicole Poweleit, Philip T. McGilvray, Timothy S. Wilson, Michael Mashore, Camille Hennessy, Sean Thomson, Bo Wang, Clinton S. Potter, Bridget Carragher
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The emerging field of microcrystal electron diffraction (MicroED) is of great interest to industrial researchers working in the drug discovery and drug development space. The promise of being able to routinely solve high-resolution crystal structures
Externí odkaz:
https://doaj.org/article/4e8f74f2a00c436abdbb1fc0f9db7a2d
Autor:
Rachel L. Palte, Veronica Juan, Yacob Gomez-Llorente, Marc Andre Bailly, Kalyan Chakravarthy, Xun Chen, Daniel Cipriano, Ghassan N. Fayad, Laurence Fayadat-Dilman, Symon Gathiaka, Heiko Greb, Brian Hall, Mas Handa, Mark Hsieh, Esther Kofman, Heping Lin, J. Richard Miller, Nhung Nguyen, Jennifer O’Neil, Hussam Shaheen, Eric Sterner, Corey Strickland, Angie Sun, Shane Taremi, Giovanna Scapin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/15828ecf3c6a4e49a73581c4631d3a3d
Autor:
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Haiqun Tang, Shu-Wei Yang, Jianping Pan, Yuriko Root, Reynalda Keh de Jesus, Christine Yang, Winnie Prosise, Priya Dayananth, Asra Mirza, Alex G. Therien, Katherine Young, Amy Flattery, Charles Garlisi, Rumin Zhang, Donald Chu, Payal Sheth, Inhou Chu, Jin Wu, Carrie Markgraf, Hai-Young Kim, Ronald Painter, Todd W. Mayhood, Edward DiNunzio, Daniel F. Wyss, Alexei V. Buevich, Thierry Fischmann, Alexander Pasternak, Shuzhi Dong, Jacqueline D. Hicks, Artjohn Villafania, Lianzhu Liang, Nicholas Murgolo, Todd Black, William K. Hagmann, Jim Tata, Emma R. Parmee, Ann E. Weber, Jing Su, Haifeng Tang
Publikováno v:
Journal of Medicinal Chemistry. 65:16234-16251
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection. Concurrent with our
Autor:
Bo Wang, Jessica F. Bruhn, Asmerom Weldeab, Timothy S. Wilson, Philip T. McGilvray, Michael Mashore, Qiong Song, Giovanna Scapin, Yiqing Lin
Publikováno v:
Chemical Communications. 58:4711-4714
One can confidently assign the absolute configuration of a chiral molecule using crystalline powders, via microcrystal electron diffraction (MicroED) analysis.
Autor:
Prasanthi Geda, Mark A. McCoy, Liping Yang, Chaomin Li, Armetta D. Hill, Xavier Fradera, Marianne L. Spatz, Matthew Ernst Voss, Carolyn Michele Cammarano, Pierre Daublain, Xiao Wang, Christopher F. Thompson, B. Wesley Trotter, C. Gary Marshall, Michael H. Reutershan, Peter Goldenblatt, Latha G. Nair, Manami Shizuka, Tammie C. Yeh, John G. Cryan, Isabelle Dussault, Michelle Martinez, Mingmei Cai, Raymond A. Kemper, Binyuan Sun, Michelle R. Machacek, Dietrich Steinhuebel, Giovanna Scapin, Michael D. Altman, Stephane L. Bogen, Matthew Christopher, Dapeng Chen, Victoria Kutilek, Weidong Pan
Publikováno v:
Journal of Medicinal Chemistry. 64:16213-16241
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward