Výsledky vyhledávání - "Giovana C. Granados"

Development and Characterization of Peptidic Fusion Inhibitors Derived from HIV-1 gp41 with Partial D-Amino Acid Substitutions

Autor: Elmostafa Bahraoui, Fabrice Gaston, Sergio Madurga, Giovana C. Granados, Francesc Rabanal, Faouzi Lakhdar-Ghazal, Ernest Giralt

Publikováno v: ChemMedChem. 4:570-581

The aim of this study was to design synthetic peptides with D-amino acid substitutions that mimic the human immunodeficiency virus (HIV) gp41 HR2 region. The objective was to develop new and active C34 analogue peptides by introducing D-amino acid po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d256d9d2dac1d9192851b0e201d0bd
https://doi.org/10.1002/cmdc.200800390

Zobrazit plný text záznamu

Design of HR1 and HR2 synthetic peptide analogs: Characterization of their antiviral activities and their capacities to induce neutralizing antibodies

Autor: Ernest Giralt, Elmostafa Bahraoui, Meritxell Teixidó, Olfa Mzoughi, Giovana C. Granados, Esther Zurita, Ibtissem Hamimmed, Miguel Moreno, Fabrice Gaston

Publikováno v: Retrovirology
Retrovirology, 2013, 10 (Suppl 1), pp.P112
Retrovirology, BioMed Central, 2013, 10 (Suppl 1), pp.P112

Background HIV-1 entry is a dynamic process with two main actors: HIV-1 envelope glycoproteins: gp120 and gp41. The entry is a key step of the infection: blockade of this step leads to an inhibition of the viral replication. Our main focus in this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2762a84dded9a838693e7420cfde86a4
https://www.hal.inserm.fr/inserm-00873099

Zobrazit plný text záznamu

Fusion intermediates of HIV-1 gp41 as targets for antibody production: design, synthesis, and HR1-HR2 complex purification and characterization of generated antibodies

Autor: Elmostafa Bahraoui, Giovana C. Granados, Olfa Mzoughi, Ernest Giralt, Fabrice Gaston, Faouzi Lakhdar-Ghazal

Publikováno v: ChemMedChem. 5(11)

The objective of this project was to study the interaction between HR1 and HR2, the stability of the complex formed, and to characterize the antibodies produced against monomeric HR1 and HR2 peptides as well as the HR1-HR2 complex. In this work, HR1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2800b370fad10fab9540d0e28ad937
https://pubmed.ncbi.nlm.nih.gov/20922745

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání