Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Giosuè Scognamiglio"'
Autor:
Amalia Luce, Marianna Abate, Giosuè Scognamiglio, Marco Montella, Domenico Iervolino, Severo Campione, Annabella Di Mauro, Orlando Sepe, Vincenzo Gigantino, Madhura S. Tathode, Gerardo Ferrara, Roberto Monaco, Gianfranco De Dominicis, Gabriella Misso, Vittorio Gentile, Renato Franco, Silvia Zappavigna, Michele Caraglia
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background Primary malignant brain tumours are more than one-third of all brain tumours and despite the molecular investigation to identify cancer driver mutations, the current therapeutic options available are challenging due to high intrat
Externí odkaz:
https://doaj.org/article/e2c137d5f4774a6083243f9bc470a2df
Autor:
Giovanna Polcaro, Luigi Liguori, Valentina Manzo, Annalisa Chianese, Giuliana Donadio, Alessandro Caputo, Giosuè Scognamiglio, Federica Dell’Annunziata, Maddalena Langella, Graziamaria Corbi, Alessandro Ottaiano, Marco Cascella, Francesco Perri, Margot De Marco, Jessica Dal Col, Giovanni Nassa, Giorgio Giurato, Pio Zeppa, Amelia Filippelli, Gianluigi Franci, Fabrizio Dal Piaz, Valeria Conti, Stefano Pepe, Francesco Sabbatino
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Efficient predictive biomarkers are needed for immune checkpoint inhibitor (ICI)-based immunotherapy in non-small cell lung cancer (NSCLC). Testing the predictive value of single nucleotide polymorphisms (SNPs) in programmed cell death 1 (PD
Externí odkaz:
https://doaj.org/article/7bab284812f0470981c3d94028bbb2f8
Autor:
Monica Cantile, Valentina Belli, Giosuè Scognamiglio, Anna Martorana, Giovanna De Pietro, Maura Tracey, Alfredo Budillon
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Leading anti-tumour therapeutic strategies typically involve surgery and radiotherapy for locally advanced (non-metastatic) cancers, while hormone therapy, chemotherapy, and molecular targeted therapy are the current treatment options for metastatic
Externí odkaz:
https://doaj.org/article/6517bcc25518443ca50774b388ea0897
Autor:
Alessandro Ottaiano, Antonella De Luca, Mariachiara Santorsola, Giosuè Scognamiglio, Annabella Di Mauro, Paolo Chiodini, Matilde Lambiase, Alessandra Sacco, Antonella Petrillo, Vincenza Granata, Roberta Fusco, Edoardo Mercadante, Nicola Martucci, Giuseppe De Luca, Antonello La Rocca, Egidio Celentano, Anna Crispo, Piergiacomo Di Gennaro, Fabiana Tatangelo, Gerardo Ferrara, Francesco Izzo, Andrea Belli, Renato Patrone, Paolo Delrio, Daniela Rega, Silvia De Franciscis, Paolo Muto, Vincenzo Ravo, Rossella Di Franco, Valentina Borzillo, Sara Santagata, Giuseppina Rea, Daniela Castaldo, Ugo Pace, Gianfranco De Feo, Stefania Scala, Guglielmo Nasti, Nicola Normanno
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract Background Metastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some patients follow a less aggressive disease course, characterized by a limited number of meta
Externí odkaz:
https://doaj.org/article/0f8b4dec1455442a95550e330fb15be2
Autor:
Alessandro Ottaiano, Mariachiara Santorsola, Anna Diana, Andrea Belli, Maria Luisa Lentini Graziano, Jessica Orefice, Renato Patrone, Annabella Di Mauro, Giosuè Scognamiglio, Fabiana Tatangelo, Mario De Bellis, Mauro Piccirillo, Francesco Fiore, Salvatore Stilo, Luca Tarotto, Marco Correra, Sara Di Lorenzo, Maurizio Capuozzo, Antonio Avallone, Lucrezia Silvestro, Antonella Bianco, Vincenza Granata, Piera Federico, Vincenzo Montesarchio, Bruno Daniele, Francesco Izzo, Guglielmo Nasti
Publikováno v:
Cancer Medicine, Vol 13, Iss 4, Pp n/a-n/a (2024)
Abstract Background and Aims Cholangiocarcinoma (CCA), a rare and aggressive hepatobiliary malignancy, presents significant clinical management challenges. Despite rising incidence and evolving treatment options, prognosis remains poor, motivating th
Externí odkaz:
https://doaj.org/article/552d3c2d92ae4db78a92b5d0a483582f
Autor:
Luca Forlani, Loris De Cecco, Vittorio Simeon, Biagio Paolini, Marina Bagnoli, Sabrina Chiara Cecere, Anna Spina, Eleonora Citeroni, Eliana Bignotti, Domenica Lorusso, Laura Arenare, Daniela Russo, Carmine De Angelis, Laura Ardighieri, Giosuè Scognamiglio, Michele Del Sesto, Germana Tognon, Daniela Califano, Clorinda Schettino, Paolo Chiodini, Francesco Perrone, Delia Mezzanzanica, Sandro Pignata, Antonella Tomassetti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-17 (2023)
Abstract Background Validated prognostic biomarkers for anti-angiogenic therapy using the anti-VEGF antibody Bevacizumab in ovarian cancer (OC) patients are still an unmet clinical need. The EGFR can contribute to cancer-associated biological mechani
Externí odkaz:
https://doaj.org/article/218fe5829cc64926a70c90f947c39308
Autor:
Roberta Fusco, Elio Di Bernardo, Adele Piccirillo, Maria Rosaria Rubulotta, Teresa Petrosino, Maria Luisa Barretta, Mauro Mattace Raso, Paolo Vallone, Concetta Raiano, Raimondo Di Giacomo, Claudio Siani, Franca Avino, Giosuè Scognamiglio, Maurizio Di Bonito, Vincenza Granata, Antonella Petrillo
Publikováno v:
Current Oncology, Vol 29, Iss 3, Pp 1947-1966 (2022)
Purpose:The purpose of this study was to discriminate between benign and malignant breast lesions through several classifiers using, as predictors, radiomic metrics extracted from CEM and DCE-MRI images. In order to optimize the analysis, balancing a
Externí odkaz:
https://doaj.org/article/d1541e52a547460dbbf1376fd0ca8de0
Autor:
Anna Passarelli, Carmela Pisano, Sabrina Chiara Cecere, Marilena Di Napoli, Sabrina Rossetti, Rosa Tambaro, Jole Ventriglia, Federica Gherardi, Eva Iannacone, Sergio Setola Venanzio, Francesco Fiore, Michele Bartoletti, Giosuè Scognamiglio, Daniela Califano, Sandro Pignata
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunotherapy is acquiring a primary role in treating endometrial cancer (EC) with a relevant benefit for many patients. Regardless, patients progressing during immunotherapy or those who are resistant represent an unmet need. The mechanisms of immun
Externí odkaz:
https://doaj.org/article/a566ec8355c14cb985e3d260165dc78e
Autor:
Alessandro Ottaiano, Roberta Penta de Vera d’Aragona, Anna Maria Trotta, Mariachiara Santorsola, Maria Napolitano, Giosuè Scognamiglio, Fabiana Tatangelo, Paolo Grieco, Silvia Zappavigna, Vincenza Granata, Francesco Perri, Amalia Luce, Giovanni Savarese, Monica Ianniello, Marika Casillo, Nadia Petrillo, Andrea Belli, Francesco Izzo, Guglielmo Nasti, Michele Caraglia, Stefania Scala
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundWe previously reported rare regressive genetic trajectories of KRAS pathogenic mutations as a specific hallmark of the genuine oligometastatic status in colorectal cancer (CRC).MethodsSurvival and prognostic impact of disease extent in 140
Externí odkaz:
https://doaj.org/article/5bcd4ae119204d419da8f4d9556a1316
Autor:
Ester Simeone, Giosuè Scognamiglio, Mariaelena Capone, Diana Giannarelli, Antonio M. Grimaldi, Domenico Mallardo, Gabriele Madonna, Marcello Curvietto, Assunta Esposito, Fabio Sandomenico, Francesco Sabbatino, Nicholas L. Bayless, Sarah Warren, SuFey Ong, Gerardo Botti, Keith T. Flaherty, Soldano Ferrone, Paolo A. Ascierto
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background Studies carried out in vitro and in a mouse model have shown that BRAF inhibitors enhance the effects of IFN-α on BRAFV600E melanoma cells through the inhibition of ERK. Therefore, the combination of vemurafenib and IFN-α in pat
Externí odkaz:
https://doaj.org/article/86e55258d57a4fdc9a2470824a69f5e9