Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Giorgio Santoni"'
Autor:
Federica Maggi, Maria Beatrice Morelli, Cristina Aguzzi, Laura Zeppa, Massimo Nabissi, Carlo Polidori, Giorgio Santoni, Consuelo Amantini
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Calcium flux is the master second messenger that influences the proliferation–apoptosis balance. The ability of calcium flux alterations to reduce cell growth makes ion channels interesting targets for therapy. Among all, we focused o
Externí odkaz:
https://doaj.org/article/e023034b9e0b48739d102eea214ac075
Autor:
Oliviero Marinelli, Emanuela Romagnoli, Federica Maggi, Massimo Nabissi, Consuelo Amantini, Maria Beatrice Morelli, Matteo Santoni, Nicola Battelli, Giorgio Santoni
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Breast cancer (BC) is the second most common type of cancer worldwide. Among targeted therapies for Hormone Receptor-positive (HR+) and Human Epidermal growth factor Receptor 2-negative (HER2−) BC, the Cyclin-Dependent Kinases (
Externí odkaz:
https://doaj.org/article/56cbc7ba5bf340f8853c628b09a09d98
Autor:
Giorgio Santoni, Consuelo Amantini, Matteo Santoni, Federica Maggi, Maria Beatrice Morelli, Angela Santoni
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Natural killer (NK) cells are a main subset of innate lymphocytes that contribute to host immune protection against viruses and tumors by mediating target cell killing and secreting a wide array of cytokines. Their functions are finely regulated by a
Externí odkaz:
https://doaj.org/article/e34e889adde24fee9d19abc57d55e3fe
Autor:
Giorgio Santoni, Consuelo Amantini, Massimo Nabissi, Federica Maggi, Antonietta Arcella, Oliviero Marinelli, Anna Maria Eleuteri, Matteo Santoni, Maria Beatrice Morelli
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Among cancers that affect the central nervous system, glioblastoma is the most common. Given the negative prognostic significance of transient receptor potential mucolipin 1 (TRPML1) channel reduction in patients with glioblastoma, as discussed in pr
Externí odkaz:
https://doaj.org/article/e775d69ae69c4c38bc0ae4afcd231493
Autor:
Cristina Aguzzi, Oliviero Marinelli, Laura Zeppa, Giorgio Santoni, Filippo Maggi, Massimo Nabissi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 132, Iss , Pp 110845- (2020)
Macrophages exert an important role in maintaining and/or ameliorating the inflammatory response. They are involved in the activation of an immune response to pathogens, with a balance between the immunomodulatory role and tissue integrity maintenanc
Externí odkaz:
https://doaj.org/article/386f660e2e9d467eaa2b631ed70399e8
Autor:
Laura Zeppa, Cristina Aguzzi, Giorgia Versari, Margherita Luongo, Maria Beatrice Morelli, Federica Maggi, Consuelo Amantini, Giorgio Santoni, Oliviero Marinelli, Massimo Nabissi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 466 (2022)
Evening Primrose oil (EPO), obtained from the seeds of Evening Primrose (Oenothera L.), is largely used as a dietary supplement, especially after cancer diagnosis. Human pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease correlated with
Externí odkaz:
https://doaj.org/article/107dd2ed1d5b4f7e80e2611ef6a02f70
Autor:
Oliviero Marinelli, Daniela Annibali, Maria Beatrice Morelli, Laura Zeppa, Sandra Tuyaerts, Cristina Aguzzi, Consuelo Amantini, Federica Maggi, Benedetta Ferretti, Giorgio Santoni, Frédéric Amant, Massimo Nabissi
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
In cancer, upregulation of coinhibitory B7 ligands has been associated with immune evasion. So far, anti-programmed death-1 (PD-1) and anti-PD-ligand 1 (PD-L1) antibodies have been used in immuno-oncology, with promising outcomes; however, it is stil
Externí odkaz:
https://doaj.org/article/616ff2258d4646bab4df0d28403c334d
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/afdacaf3be164d7e962ef35c9b05403a
Autor:
Giorgio Santoni, Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Matteo Santoni, Angela Santoni
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The TRPML channels (TRPML1, TRPML2, and TRPML3), belonging to the mucolipin TRP subfamily, primary localize to a population of membrane-bonded vesicles along the endocytosis, and exocytosis pathways. Human viruses enter host cells by plasma membrane
Externí odkaz:
https://doaj.org/article/fcea628c9be64115b133a20378e66995
Autor:
Giorgio Santoni, Federica Maggi, Consuelo Amantini, Oliviero Marinelli, Massimo Nabissi, Maria Beatrice Morelli
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Mucolipins (TRPML) are endosome/lysosome Ca2+ permeable channels belonging to the family of transient receptor potential channels. In mammals, there are three TRPML proteins, TRPML1, 2, and 3, encoded by MCOLN1-3 genes. Among these channels, TRPML1 i
Externí odkaz:
https://doaj.org/article/6d2f541ab2e145e1852103bf3f833eb2