Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Giorgio Rovelli"'
Autor:
Martin C Herzig, Michael Bidinosti, Tatjana Schweizer, Thomas Hafner, Christine Stemmelen, Andreas Weiss, Simone Danner, Nella Vidotto, Daniela Stauffer, Carmen Barske, Franziska Mayer, Peter Schmid, Giorgio Rovelli, P Herman van der Putten, Derya R Shimshek
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36581 (2012)
The G2019S mutation in the multidomain protein leucine-rich repeat kinase 2 (LRRK2) is one of the most frequently identified genetic causes of Parkinson's disease (PD). Clinically, LRRK2(G2019S) carriers with PD and idiopathic PD patients have a very
Externí odkaz:
https://doaj.org/article/91e76d844a7f47b8b87909b246097341
Autor:
P. Herman van der Putten, Diethilde Theil, Peter Schmid, Klemens Kaupmann, Christian Schnell, Derya R. Shimshek, Martina Stirn, Rainer Kuhn, Martin C. Herzig, Armelle Grevot, Carine Kolly, Tatjana Schweizer, Bernd Kinzel, Federico Bolognani, Giorgio Rovelli, Thomas Hafner, Troxler Thomas J, Christine Stemmelen, Elke Persohn, Simone Danner, Matthias Mueller
Publikováno v:
Human Molecular Genetics
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), but the underlying pathophysiological mechanisms and the normal function of this large multidomain protein remain speculative. To address the role of this pr
Autor:
Giorgio Rovelli, Iria Carballo-Carbajal, Diane Chan, Benjamin Wolozin, Susanne Weber-Endress, Thomas Gasser, Christian Klein, Philipp J. Kahle, Nadja Patenge
Publikováno v:
Cellular Signalling. 22:821-827
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of autosomal-dominant Parkinson's disease (PD). The second known autosomal-dominant PD gene (SNCA) encodes alpha-synuclein, which is deposited in Lewy bodies, the neuropath
Autor:
Thomas Gasser, Wolfdieter Springer, Christoph Schall, Philipp J. Kahle, Giorgio Rovelli, Christian Klein
Publikováno v:
Journal of Neurochemistry. 111:703-715
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are the most common cause of autosomal-dominant familial and late-onset sporadic Parkinson's disease (PD). LRRK2 is a large multi-domain protein featuring a GTP-binding C-terminal of
Autor:
Ulkan Kilic, Ertugrul Kilic, Dirk M. Hermann, Andreas Wippel, Giorgio Rovelli, Herman van der Putten, Peter Vogel, Bernd W. Böttiger, Christoph Wiessner, Mia Kim
Publikováno v:
Brain Research. 1185:293-300
In ischemic stroke, cytosolic death pathways are activated in injured neurons destined to die. Neuronal injury is modulated by cell surface receptors, among which the tumor necrosis factor receptor family obtained particular interest. Cytokine respon
Autor:
Stefan F. Lichtenthaler, Bruno Martoglio, Elena Friedmann, Kerstin Maylandt, Daniela Stauffer, Sarah Vreugde, Giorgio Rovelli, Simone Schleeger, Peer-Hendrik Kuhn, Ehud Hauben
Publikováno v:
Nature Cell Biology. 8:843-848
Homologues of signal peptide peptidase (SPPLs) are putative aspartic proteases that may catalyse regulated intramembrane proteolysis of type II membrane-anchored signalling factors. Here, we show that four human SPPLs are each sorted to a different c
Autor:
Elena Friedmann, Andreas Weihofen, Marius K. Lemberg, Giorgio Rovelli, Kumlesh K. Dev, Uwe Jochen Dengler, Bruno Martoglio
Publikováno v:
Journal of Biological Chemistry. 279:50790-50798
The human genome encodes seven intramembrane-cleaving GXGD aspartic proteases. These are the two presenilins that activate signaling molecules and are implicated in Alzheimer's disease, signal peptide peptidase (SPP), required for immune surveillance
Autor:
Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described h
Autor:
Kumlesh K. Dev, Daniela Stauffer, Natalie Finney, Fabienne Walther, Giorgio Rovelli, Pierre-Yves Mantel
Publikováno v:
Journal of Biological Chemistry. 278:16054-16058
Parkin is a ubiquitin-protein isopeptide ligase (E3) involved in ubiquitin/proteasome-mediated protein degradation. Mutations in the parkin gene cause a loss-of-function and/or alter protein levels of parkin. As a result, the toxic build-up of parkin
Autor:
Klemens Kaupmann, Tewis Bouwmeester, Marc Meyer, Sjouke Hoving, Lionel Muller, Petranka Krumova, Lauran Reyniers, Bertran Gerrits, Giorgio Rovelli, Johannes Voshol, Doriano Fabbro, Andreas Bauer, Jean-Marc Taymans, Veerle Baekelandt, Evy Lobbestael, Daniela Stauffer
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(7)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of autosomal-dominant forms of Parkinson's disease. LRRK2 is a modular, multidomain protein containing 2 enzymatic domains, including a kinase domain, as well as several prot