In Vivo Metabolic Responses to Different Formulations of Amino Acid Mixtures for the Treatment of Phenylketonuria (PKU)

Autor: Nadia Giarratana, Luciana Giardino, Andrea Bighinati, Giorgio Reiner, Júlio César Rocha

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 4, p 2227 (2022)

Phenylketonuria (PKU) is a rare autosomal recessive inborn error of metabolism where the mainstay of treatment is a Phe restricted diet consisting of a combination of limited amounts of natural protein with supplementation of Phe-free or low-Phe prot

Externí odkaz: https://doaj.org/article/3a1cf3fba38d4b60b74321c709e8318e

Amino Acid Plasma Profiles from a Prolonged-Release Protein Substitute for Phenylketonuria: A Randomized, Single-Dose, Four-Way Crossover Trial in Healthy Volunteers

Autor: Mika Scheinin, Anna Barassi, Jouni Junnila, Zsófia Lovró, Giorgio Reiner, Essi Sarkkinen, Anita MacDonald

Publikováno v: Nutrients, Vol 12, Iss 6, p 1653 (2020)

Several disorders of amino acid (AA) metabolism are treated with a protein-restricted diet supplemented with specific AA mixtures. Delivery kinetics impacts AA absorption and plasma concentration profiles. We assessed plasma profiles after ingestion

Externí odkaz: https://doaj.org/article/3d4ef84e75524ecb932fca74135f6e85

MORE PHYSIOLOGICAL ABSORPTION OF A PROLONGED RELEASE AMINO ACID SUPPLEMENT: PRECLINICAL EVIDENCE OF IMPROVED AMINO ACID UTILIZATION

Autor: Katie Draper, Nadia Giarratana, Luciana Giardino, Andrea Bighinati, Giorgio Reiner

Publikováno v: Molecular Genetics and Metabolism. 138:107406

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0a206619d5dafd2d530b8707a5656e8
https://doi.org/10.1016/j.ymgme.2023.107406

A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene

Autor: Nadia Giarratana, Balan Rajan, Kannan Kamala, Michelle Mendenhall, Giorgio Reiner

Publikováno v: European Archives of Oto-Rhino-Laryngology

Introduction To eliminate the COVID-19 pandemic, the transmission of the virus SARS-CoV-2 among the population needs to be blocked and/or at least reduced. Upper respiratory tract viral loads are highest in the early stages of the disease, and high l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b76422082b95e95083d82f3affa4c6
https://pubmed.ncbi.nlm.nih.gov/33575830

A New Phe-Free Protein Substitute Engineered to Allow a Physiological Absorption of Free Amino Acids for Phenylketonuria

Autor: Giorgio Reiner, Guglielmo Gallina, Valentina Panzeri, Andrea Canobbio, Nadia Giarratana, Alessandra Frangi

Publikováno v: Journal of Inborn Errors of Metabolism and Screening, Vol 6 (2018)
Journal of Inborn Errors of Metabolism and Screening v.6 2018
Journal of Inborn Errors of Metabolism and Screening
Instituto Genética para Todos (IGPT)
instacron:IGPT
Journal of Inborn Errors of Metabolism and Screening, Volume: 6, Article number: e170030, Published: 28 FEB 2019

An innovative technology (Physiomimic Technology) has been applied to amino acids (AAs) formulated for patients with phenylketonuria, with the objective of masking AA taste and odor and prolonging AA release in the gut, allowing a physiological absor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db92b028659946ff8bb8b46b9ca60148
https://doaj.org/article/5b2f68edb20847faac229194b80859b3