Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Giorgio Nanni"'
Publikováno v:
Drug and Chemical Toxicology. 28:91-104
Our line of researches follows the hypothesis that dolichol and retinol metabolism might be interrelated and involved in liver fibrosis. To this end, in this study rats were subjected to chronic treatment with thioacetamide (TAA) (300 mg/L liquid die
Association of Thioacetamide and Ethanol Treatment: Dolichol and Retinol in Isolated Rat Liver Cells
Autor:
Giorgio Nanni, Claudio Canepa, Damiano Cottalasso, A. Casu, Anna Maria Bassi, Giuseppe Maloberti
Publikováno v:
Drug and Chemical Toxicology. 27:55-67
Our aim was to study the distribution of dolichol, dolichol isoprenoids, and retinol in hepatocytes, Kupffer, sinusoidal endothelial and two subfractions of hepatic stellate cells, --Ito-1 and Ito-2--, after chronic treatment of rats for 2 and 4 mont
Autor:
Claudio Canepa, Federica Majorani, Giuseppe Maloberti, Giorgio Nanni, Anna Maria Bassi, A. Casu
Publikováno v:
Experimental and Toxicologic Pathology. 54:43-50
The content of dolichol, an isoprenoid present in all biological membranes, was determined in isolated sinusoidal liver cells after treatment of rats for 2 and 4 months with a low dosage of the hepatotoxin thioacetamide. The significant decrease in d
Publikováno v:
Life Sciences. 67:2293-2304
We studied dolichol, on account of its role in membrane fluidity and fusion, and retinol, on account of its behaviour in liver fibrosis, in isolated parenchymal and sinusoidal rat liver cells after CCl4 treatment for 3, 5 and 7 weeks. Retinol uptake
Autor:
Luigi Fontana, Cinzia Domenicotti, Damiano Cottalasso, A. Bellocchio, Maria Adelaide Pronzato, Raffaella Norese, Giorgio Nanni
Publikováno v:
Toxicology. 143:283-292
Previous investigations have demonstrated that 1,2-dichloroethane (DCE) poisoning affects dolichol (Dol) concentration in rat liver. Dol, a long-chain polyprenol, is considered an important membrane component: as dolichyl phosphate, it is rate limiti
Publikováno v:
Life Sciences. 65:71-79
Aim of this study was to ascertain whether an impairment of communication between parenchymal and non-parenchymal liver cells involves vitamin A intercellular transport. The following approach was adopted: liver cells were isolated from rats treated
Publikováno v:
Cell Biochemistry and Function. 16:203-209
The liver sinusoids, that are considered as a functional unit, harbour four types of sinusoidal cells (Ito, Kupffer, endothelial and pit cells). Dolichol content has been determined in many tissues and subcellular compartments, alteration has been re
Autor:
Umberto M. Marinari, Cinzia Domenicotti, Giorgio Nanni, A. Bellocchio, Damiano Cottalasso, Nicola Traverso, Maria Vittoria Gianelli, Maria Adelaide Pronzato
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:730-737
Data obtained in our laboratory had suggested that acute ethanol administration (6 g/kg body weight) selectively and rapidly affects the Intracellular system of protein glycosylation at the level of the Golgi apparatus. Dolichols are important membra
Autor:
Giorgio Nanni, Luigi Robbiano, Margherita Ferro, Francesca Mattioli, Daniela Adamo, Anna Maria Bassi
Publikováno v:
Scopus-Elsevier
α-Hexachlorocyclohexane (α-HCH) was examined for cytotoxicity, genotoxicity and cytochrome P450 induction in primary cultures of mouse, rat and human hepatocytes and in three hepatoma cell lines (Hepa 1c1c7, FaO and Hep G2, from mouse, rat and man,
Publikováno v:
Life Sciences. 60:21-28
Dolichol has been determined in many tissues but to date no data are available on liver Ito (fat storing) cells. In this note dolichol was determined in two subpopulations of liver Ito cells isolated from rats pretreated with vitamin A: Ito-1, vitami