Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Giorgio Lagna"'
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107971- (2023)
Summary: Drosha is a core component of the Microprocessor complex that cleaves primary-microRNAs (pri-miRNAs) to generate precursor-miRNA and regulates the expression of ∼80 ribosomal protein (RP) genes. Despite the fact that mutations in the amino
Externí odkaz:
https://doaj.org/article/3e266cd1195d4f5694089fd92b89ec41
Autor:
Xuan Jiang, John S. Hawkins, Jerry Lee, Carlos O. Lizama, Frank L. Bos, Joan P. Zape, Prajakta Ghatpande, Yongbo Peng, Justin Louie, Giorgio Lagna, Ann C. Zovein, Akiko Hata
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Hematopoietic stem and progenitor cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver but what regulates this switch is unknown. Here, the authors show that changing miRNA biogenesis and leukotriene B4
Externí odkaz:
https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4
SummaryThe ribonuclease (RNase) III enzyme Drosha enables processing of microRNA (miRNA) primary transcripts (pri-miRNAs) and control of ribosomal protein (RP) biogenesis by the Microprocessor. The extensively studied carboxyl-terminal half of Drosha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfa16e93293452a5dd00176c2832cef
https://escholarship.org/uc/item/1ds2g4r4
https://escholarship.org/uc/item/1ds2g4r4
Autor:
Giorgio Lagna, Akiko Hata
Publikováno v:
Cell Chem Biol
Cell chemical biology, vol 28, iss 5
Cell chemical biology, vol 28, iss 5
Tumor suppressor genes represent a major class of oncogenic drivers. However, direct targeting of loss-of-function tumor suppressors remains challenging. To address this gap, we explored a variant-directed chemical biology approach to reverse the los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa6ab86734668cad4d1168767b6c4442
https://doi.org/10.1016/j.chembiol.2021.04.023
https://doi.org/10.1016/j.chembiol.2021.04.023
Autor:
Lorenzo Calviello, Chuwen Lin, Brian L. Black, Xuan Jiang, Prajakta Ghatpande, Amit Prabhakar, Wanpeng Wang, Giorgio Lagna, Srivats Venkataramanan, Stephanie M. Van der Voorn, Barbara Celona, Stephen N. Floor, Akiko Hata
Ribosome biogenesis in eukaryotes requires stoichiometric production and assembly of 80 ribosomal proteins (RPs) and 4 ribosomal RNAs, and its rate must be coordinated with cellular growth. The indispensable regulator of RP biosynthesis is the 5’-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfe07765dad3d859029cac338af1d08
https://doi.org/10.1101/2020.04.24.060236
https://doi.org/10.1101/2020.04.24.060236
Autor:
Ann C. Zovein, John S. Hawkins, Prajakta Ghatpande, Carlos Lizama, Frank L. Bos, Jerry Lee, Yongbo Peng, Giorgio Lagna, Joan P. Zape, Akiko Hata, Xuan Jiang, Justin Louie
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature communications, vol 8, iss 1
Jiang, X; Hawkins, JS; Lee, J; Lizama, CO; Bos, FL; Zape, JP; et al.(2017). Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-00137-y. UCSF: Retrieved from: http://www.escholarship.org/uc/item/22b5c9x9
Nature Communications
Nature communications, vol 8, iss 1
Jiang, X; Hawkins, JS; Lee, J; Lizama, CO; Bos, FL; Zape, JP; et al.(2017). Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-00137-y. UCSF: Retrieved from: http://www.escholarship.org/uc/item/22b5c9x9
Hematopoietic stem and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequently switch niche to the fetal liver through unknown mechanisms. Here we report that vascular endothelium-specific deletion of mouse Drosha (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0823d90e39dbfe036c6f4b0292515534
https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4
https://doaj.org/article/811b54bd0de3489e841c1856c5f439e4
Autor:
Akiko Hata, Jean-Charles Neel, Justin Louie, Matthew T. Blahna, Ge Yu, Prajakta Ghatpande, Giorgio Lagna
Next-generation sequencing has uncovered microRNAs (miRNAs) that undergo sequence modifications, known as isomiRs. Their physiological significance, however, remains uncertain, partly because they generally comprise a small fraction of total miRNAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188ba229ad883f6e704eff36aac7482e
Autor:
Akiko Hata, Giorgio Lagna
Publikováno v:
Current opinion in hematology. 26(3)
Author(s): Hata, Akiko; Lagna, Giorgio | Abstract: Purpose of reviewThe TGFβ (transforming growth factor β) superfamily - a large group of structurally related and evolutionarily conserved proteins - profoundly shapes and organizes the vasculature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9900afcffa1e99408dce0a3872a0ad
https://pubmed.ncbi.nlm.nih.gov/30855334
https://pubmed.ncbi.nlm.nih.gov/30855334
Autor:
Nicholas W. Morrell, Mark Southwood, Stephen Moore, Xudong Yang, Sanna Vattulainen-Collanus, Giorgio Lagna, Akiko Hata, Prajakta Ghatpande
Publikováno v:
Communications biology, vol 1, iss 1
Vattulainen-Collanus, Sanna; Southwood, Mark; Yang, Xu Dong; Moore, Stephen; Ghatpande, Prajakta; Morrell, Nicholas W; et al.(2018). Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.. Communications biology, 1(1), 149. doi: 10.1038/s42003-018-0152-1. UCSF: Retrieved from: http://www.escholarship.org/uc/item/90t429nn
Communications Biology, Vol 1, Iss 1, Pp 1-15 (2018)
Vattulainen-Collanus, Sanna; Southwood, Mark; Yang, Xu Dong; Moore, Stephen; Ghatpande, Prajakta; Morrell, Nicholas W; et al.(2018). Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.. Communications biology, 1(1), 149. doi: 10.1038/s42003-018-0152-1. UCSF: Retrieved from: http://www.escholarship.org/uc/item/90t429nn
Communications Biology, Vol 1, Iss 1, Pp 1-15 (2018)
The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a7f399de677982be2f1e75a5b2e5a4
https://doi.org/10.1038/s42003-018-0152-1
https://doi.org/10.1038/s42003-018-0152-1
Autor:
Akiko Hata, Xuan Jiang, Daniel O. Hart, Jamie McDonald, Melissa Sandoval, Mai Baalbaki, Giorgio Lagna, Whitney Wooderchak-Donahue, Shaun R. Coughlin, Pinar Bayrak-Toydemir, Hilary Clay, Prajakta Ghatpande
Publikováno v:
Science signaling, vol 11, iss 513
Jiang, Xuan; Wooderchak-Donahue, Whitney L; McDonald, Jamie; Ghatpande, Prajakta; Baalbaki, Mai; Sandoval, Melissa; et al.(2018). Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.. Science signaling, 11(513), eaan6831-eaan6831. doi: 10.1126/scisignal.aan6831. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1mh2x7w0
Jiang, Xuan; Wooderchak-Donahue, Whitney L; McDonald, Jamie; Ghatpande, Prajakta; Baalbaki, Mai; Sandoval, Melissa; et al.(2018). Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.. Science signaling, 11(513), eaan6831-eaan6831. doi: 10.1126/scisignal.aan6831. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1mh2x7w0
The transforming growth factor–β (TGF-β) and bone morphogenetic protein (BMP) family of cytokines critically regulates vascular morphogenesis and homeostasis. Impairment of TGF-β or BMP signaling leads to heritable vascular disorders, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f93f32bb541c3db26147892261c6c90
https://escholarship.org/uc/item/1mh2x7w0
https://escholarship.org/uc/item/1mh2x7w0