Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Giorgio Giannattasio"'
Autor:
Kimberly Umans, Heinz Wiendl, Peter McCroskery, Wanda Castro-Borrero, Oksana Mokliatchouk, Giorgio Giannattasio, Steven J. Greenberg, Benjamin Turner, Gavin Giovannoni
Publikováno v:
Multiple Sclerosis Journal. 24:1725-1736
Background: Reversible lymphocyte count reductions have occurred following daclizumab beta treatment for relapsing–remitting multiple sclerosis. Objective: To analyse total and differential lymphocyte levels and relationship with infection status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ac31f10fcbba4ea08b55689a2e902c
https://doi.org/10.1177/1352458517729464
https://doi.org/10.1177/1352458517729464
Autor:
Eva Havrdova, Xiaojun You, Gavin Giovannoni, Susan A. Gauthier, Ping Wang, Giorgio Giannattasio, Steven J. Greenberg, Ludwig Kappos, Bhupendra Khatri
Publikováno v:
Multiple Sclerosis Journal. 23:1736-1747
Background: No evidence of disease activity (NEDA) is a composite endpoint being increasingly applied as an outcome measure in clinical trials as well as proposed for individual therapeutic decisions in multiple sclerosis (MS). Objective: Assess the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21e8400fa5ebe0017aaf7747fc328dd
https://doi.org/10.1177/1352458516683266
https://doi.org/10.1177/1352458516683266
Autor:
Wei Xing, Maria Simarro, Richard L. Stevens, Antonio Orduña, Paul A. Anderson, Samantha Stewart, Giorgio Giannattasio, Emma-Maria Lundequist, Joshua A. Boyce
Publikováno v:
Immunology Letters. 146:8-14
T-cell intracellular antigen-1 (TIA-1) is a translational repressor that dampens the production of proinflammatory cytokines and enzymes. In this study we investigated the role of TIA-1 in a mouse model of pulmonary inflammation induced by exposure t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d78fb1ea2f5680dfd2e7a2e54cd52eb
https://doi.org/10.1016/j.imlet.2012.04.001
https://doi.org/10.1016/j.imlet.2012.04.001
Autor:
Giorgio Giannattasio, Barbara Balestrieri, Shin Ohta, Joshua A. Boyce, Joshua R. Boyce, Wei Xing
Publikováno v:
The Journal of Immunology. 187:1486-1495
We show that the P2Y6 receptor, a purinergic G protein-coupled receptor with a high affinity for the nucleotide uridine diphosphate, is an important endogenous inhibitor of T cell function in allergic pulmonary inflammation. Mice conditionally defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d8dfc05929c32d8281675dd4d5e01d6
https://doi.org/10.4049/jimmunol.1003669
https://doi.org/10.4049/jimmunol.1003669
Autor:
Ludwig Kappos, Susan A. Gauthier, Ping Wang, Bhupendra Khatri, Giorgio Giannattasio, Steven J. Greenberg, Gavin Giovannoni, Eva Havrdova
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 88:A42.1-A42
Background Significantly more DECIDE patients receiving subcutaneous daclizumab HYP (daclizumab) 150 mg achieved no evidence of disease activity (NEDA) vs intramuscular interferon beta-1a (IFNβ1a) 30 µg over 96 weeks. Early residual disease activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd59074f45e3b938befb295aeab09b1
https://doi.org/10.1136/jnnp-2017-abn.144
https://doi.org/10.1136/jnnp-2017-abn.144
Publikováno v:
Journal of Allergy and Clinical Immunology. 116:1000-1006
Secretory phospholipases A(2) (sPLA(2)s) are molecules released in plasma and biologic fluids of patients with systemic inflammatory, autoimmune, and allergic diseases. Several sPLA(2) isoforms are expressed and released by such human inflammatory ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464c91a835299155fb3c47caba1d596f
https://doi.org/10.1016/j.jaci.2005.08.011
https://doi.org/10.1016/j.jaci.2005.08.011
Autor:
Massimo Triggiani, V. Forte, Giorgio Giannattasio, Francescopaolo Granata, Stefania Loffredo, Barbara Balestrieri
Publikováno v:
Clinical Experimental Allergy Reviews. 4:129-134
Summary Macrophages are tissue-specific, highly specialized components of the mononuclear phagocyte system (MPS). In the lung macrophages constitute a heterogeneous cell population distributed in different compartments. At least two populations of ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1739dc9e2e5c3559ee84be1bb2de9085
https://doi.org/10.1111/j.1472-9725.2004.00045.x
https://doi.org/10.1111/j.1472-9725.2004.00045.x
Autor:
Giorgio Giannattasio, A de Paulis, Massimo Triggiani, Gianni Marone, Michael H. Gelb, Francescopaolo Granata, Barbara Balestrieri
Publikováno v:
Clinical Experimental Allergy. 34:241-249
Summary Background Basophils and mast cells play a major role in the pathogenesis of allergic disorders by releasing several proinflammatory mediators. Some histamine H1 receptor antagonists exert antiinflammatory activities by modulating mediator re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c8566e26117cb1af9f84e070624311
https://doi.org/10.1111/j.1365-2222.2004.01851.x
https://doi.org/10.1111/j.1365-2222.2004.01851.x
Autor:
Gianni Marone, Giorgio Giannattasio, Massimo Triggiani, Francescopaolo Granata, Barbara Balestrieri, Angelica Petraroli
Publikováno v:
International Archives of Allergy and Immunology. 131:153-163
Phospholipases A2 (PLA2s) are enzymes responsible for mobilization of fatty acids, including arachidonic acid (AA), from phospholipids. These enzymes are classified as high-molecular-weight cytosolic PLA2s (cPLA2s) and low-molecular-weight secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfa720c9fae0132e852b839473654ed9
https://doi.org/10.1159/000071481
https://doi.org/10.1159/000071481
Autor:
Steven Greenberg, Giorgio Giannattasio, Ping Wang, Emna Bourkhis, Eva Havrdova, Gavin Giovannoni, Ludwig Kappos
Publikováno v:
Revue Neurologique. 173:S119
Introduction Dans DECIDE, un pourcentage significativement superieur de patients recevant Dac HYP 150 mg (daclizumab), une forme structurellement distincte du daclizumab, a presente une absence d’activite de la maladie (NEDA) vs interferon beta-1a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3bc77bc98ea90a36d98e08a178f6dc0
https://doi.org/10.1016/j.neurol.2017.01.204
https://doi.org/10.1016/j.neurol.2017.01.204