Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Giorgio Gaglia"'
Autor:
Albert Grinshpun, Douglas Russo, Wen Ma, Ana Verma, Francisco Hermida-Prado, Shira Sherman, Giorgio Gaglia, Sheheryar Kabraji, Gregory Kirkner, Melissa E. Hughes, Nancy U. Lin, Zachary Sandusky, Agostina Nardone, Cristina Guarducci, Quang-De Nguyen, Sandro Santagata, Zsuzsanna Nagy, Rinath Jeselsohn
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The ESR1 ligand binding domain activating mutations are the most prevalent genetic mechanism of acquired endocrine resistance in metastatic hormone receptor-positive breast cancer. These mutations confer endocrine resistance that remains est
Externí odkaz:
https://doaj.org/article/7c7a103652a4404eac1f649798184d56
Publikováno v:
MethodsX, Vol 10, Iss , Pp 102196- (2023)
Single-cell RNA sequencing (scRNA-seq) experiments provide opportunities to peer into complex tissues at single-cell resolution. However, insightful biological interpretation of scRNA-seq data relies upon precise identification of cell types. The abi
Externí odkaz:
https://doaj.org/article/ddb0bff18b1b40dda6c78781fb78cab5
Autor:
Luke Whitesell, Susan Lindquist, Tyler Jacks, Forest White, Jane B. Trepel, Nancy U. Lin, Sandro Santagata, Demi Sandel, Giorgio Gaglia, Sunmin Lee, Lauren Stopfer, Alex M. Jaeger
Purpose:Despite the accumulation of extensive genomic alterations, many cancers fail to be recognized as “foreign” and escape destruction by the host immune system. Immunotherapies designed to address this problem by directly stimulating immune e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d886db7463972a6c9c5dfd815d884e
https://doi.org/10.1158/1078-0432.c.6529022.v1
https://doi.org/10.1158/1078-0432.c.6529022.v1
Autor:
Luke Whitesell, Susan Lindquist, Tyler Jacks, Forest White, Jane B. Trepel, Nancy U. Lin, Sandro Santagata, Demi Sandel, Giorgio Gaglia, Sunmin Lee, Lauren Stopfer, Alex M. Jaeger
Clinical Data Pan Cancer Immune Profiling Codeset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014b65347181f5d7c1aec737291b978f
https://doi.org/10.1158/1078-0432.22475240
https://doi.org/10.1158/1078-0432.22475240
Autor:
Luke Whitesell, Susan Lindquist, Tyler Jacks, Forest White, Jane B. Trepel, Nancy U. Lin, Sandro Santagata, Demi Sandel, Giorgio Gaglia, Sunmin Lee, Lauren Stopfer, Alex M. Jaeger
Supplementary Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18420295c3bb19bb5d13f127956e89b5
https://doi.org/10.1158/1078-0432.22475228.v1
https://doi.org/10.1158/1078-0432.22475228.v1
Autor:
Simon Warchol, Robert Krueger, Ajit Johnson Nirmal, Giorgio Gaglia, Jared Jessup, Cecily C. Ritch, John Hoffer, Jeremy Muhlich, Megan L. Burger, Tyler Jacks, Sandro Santagata, Peter K. Sorger, Hanspeter Pfister
Publikováno v:
IEEE Trans Vis Comput Graph
New highly-multiplexed imaging technologies have enabled the study of tissues in unprecedented detail. These methods are increasingly being applied to understand how cancer cells and immune response change during tumor development, progression, and m
Autor:
Giorgio Gaglia, Megan L. Burger, Cecily C. Ritch, Danae Rammos, Yang Dai, Grace E. Crossland, Sara Z. Tavana, Simon Warchol, Alex M. Jaeger, Santiago Naranjo, Shannon Coy, Ajit J. Nirmal, Robert Krueger, Jia-Ren Lin, Hanspeter Pfister, Peter K Sorger, Tyler Jacks, Sandro Santagata
Publikováno v:
Cancer Cell. 41:871-886.e10
Lymphocytes play a key role in immune surveillance of tumors, but our understanding of the spatial organization and physical interactions that facilitate lymphocyte anti-cancer functions is limited. Here, we used multiplexed imaging, quantitative spa
Autor:
Megan L. Burger, Giorgio Gaglia, Claire C. Ritch, Danae Rammos, Yang Dai, Grace E. Crossland, Sara Z. Tavana, Simon Warchol, Alex M. Jaeger, Santiago Naranjo, Shannon Coy, Ajit J. Nirmal, Robert Krueger, Jia-Ren Lin, Hanspeter Pfister, Peter K. Sorger, Tyler Jacks, Sandro Santagata
Publikováno v:
Cancer Research. 83:5877-5877
Cancer immunotherapies that activate cytotoxic T cell responses against tumors have been remarkably effective in some patients, but the determinants of response remain unclear. To investigate how spatial organization of T cells might influence immuno
Using single nuclear RNAseq to assess impact of AAV-ARSA gene therapy on oligodendrocyte populations
Autor:
Yinyin Huang, Shyam Ramachandran, Swathi Ayloo, Jeffery Ardinger, Dongyu Liu, Joseph Gans, Stephen L. Madden, Giorgio Gaglia, Erin Teeple, Nima Nouri, Martin Goulet, Christian Mueller, Virginia Savova
Publikováno v:
Molecular Genetics and Metabolism. 138:107156
Autor:
Carmen G Li, Clarence Yapp, Luke Whitesell, Susan Lindquist, Kristopher A. Sarosiek, Sandro Santagata, Rumana Rashid, Peter K. Sorger, Giorgio Gaglia, Gaurav N. Joshi
Publikováno v:
Nature cell biology
Under proteotoxic stress, some cells survive whereas others die. The mechanisms governing this heterogeneity in cell fate remain unknown. Here we report that condensation and phase transition of heat-shock factor 1 (HSF1), a transcriptional regulator