Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Giorgio Fois"'
Autor:
Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B. Ruiz-Blanco, Markus Hoffmann, Konstantin M. J. Sparrer, Stefan Pöhlmann, Elsa Sanchez-Garcia, Frank Kirchhoff, Manfred Frick, Jan Münch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically
Externí odkaz:
https://doaj.org/article/056726122e3545e6b5177624a1dc537a
Autor:
Ruxandra Neatu, Ifeanyi Enekwa, Dean J. Thompson, Edward C. Schwalbe, Giorgio Fois, Gina Abdelaal, Stephany Veuger, Manfred Frick, Peter Braubach, Sterghios A. Moschos
Publikováno v:
Non-Coding RNA, Vol 8, Iss 6, p 83 (2022)
LncRNAs are involved in regulatory processes in the human genome, including gene expression. The rs35705950 SNP, previously associated with IPF, overlaps with the recently annotated lncRNA AC061979.1, a 1712 nucleotide transcript located within the M
Externí odkaz:
https://doaj.org/article/37e1aefca43d4134b2b902b6fae405d8
Autor:
Julia Eisele, Simone Schreiner, Joscha Borho, Stephan Fischer, Sebastian Heber, Sascha Endres, Maximilian Fellermann, Lisa Wohlgemuth, Markus Huber-Lang, Giorgio Fois, Michael Fauler, Manfred Frick, Holger Barth
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects on mammalian cells, proteolytically activated C2II (C2IIa) forms b
Externí odkaz:
https://doaj.org/article/1e1b299521ec4274ae589d37589b6ff1
Autor:
Sebastian Heber, Lara Barthold, Jan Baier, Panagiotis Papatheodorou, Giorgio Fois, Manfred Frick, Holger Barth, Stephan Fischer
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Clostridioides (C.) difficile produces the exotoxins TcdA and TcdB, which are the predominant virulence factors causing C. difficile associated disease (CDAD). TcdA and TcdB bind to target cells and are internalized via receptor-mediated endocytosis.
Externí odkaz:
https://doaj.org/article/da233ee33c7d4c68b6c60ad90c696958
Autor:
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients
Externí odkaz:
https://doaj.org/article/2dc6bac21e55498b89173aacf79937fe
Autor:
Katharina Ernst, Marc Landenberger, Julian Nieland, Katharina Nørgaard, Manfred Frick, Giorgio Fois, Roland Benz, Holger Barth
Publikováno v:
Toxins, Vol 13, Iss 6, p 390 (2021)
The clinically highly relevant Clostridioides (C.) difficile releases several AB-type toxins that cause diseases such as diarrhea and pseudomembranous colitis. In addition to the main virulence factors Rho/Ras-glycosylating toxins TcdA and TcdB, hype
Externí odkaz:
https://doaj.org/article/1354e412c0384bd7bc854bf912f952d8
Autor:
Ina Lackner, Birte Weber, Meike Baur, Melanie Haffner-Luntzer, Tim Eiseler, Giorgio Fois, Florian Gebhard, Borna Relja, Ingo Marzi, Roman Pfeifer, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hans-Christoph Pape, Miriam Kalbitz, TREAT Research Group
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background and Purpose: Post-traumatic cardiac dysfunction often occurs in multiply injured patients (ISS ≥ 16). Next to direct cardiac injury, post-traumatic cardiac dysfunction is mostly induced by the release of inflammatory biomarkers. One of t
Externí odkaz:
https://doaj.org/article/076d284c588e4077af811e216906ca50
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 14, p 4973 (2020)
The distal lung provides an intricate structure for gas exchange in mammalian lungs. Efficient gas exchange depends on the functional integrity of lung alveoli. The cells in the alveolar tissue serve various functions to maintain alveolar structure,
Externí odkaz:
https://doaj.org/article/3c844da0c3694c309214e9e53cf04102
Autor:
Birte Weber, Ina Lackner, Meike Baur, Giorgio Fois, Florian Gebhard, Ingo Marzi, Hubert Schrezenmeier, Borna Relja, Miriam Kalbitz
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 5, p 1421 (2020)
Background and purpose: The aim of the study was to determine the effects of post-traumatically released High Mobility Group Box-1 protein (HMGB1) and extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic option to capture ci
Externí odkaz:
https://doaj.org/article/d70b8f75d5d348ee837b82daf800283c
Autor:
Oanh N. Hoang, Anna Ermund, Ana M. Jaramillo, Dalia Fakih, Cory B. French, Jose R. Flores, Harry Karmouty-Quintana, Jesper M. Magnusson, Giorgio Fois, Michael Fauler, Manfred Frick, Peter Braubach, Joshua B. Hales, Richard C. Kurten, Reynold Panettieri, Leoncio Vergara, Camille Ehre, Roberto Adachi, Michael J. Tuvim, Gunnar C. Hansson, Burton F. Dickey
Publikováno v:
American journal of respiratory and critical care medicine. 206(9)