Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Giorgio Belvedere"'
Autor:
Giovanna Tagliabue, Giovanna Damia, Luigi Imperatori, Maurizio D'Incalci, E. G. E. de Vries, Giorgio Belvedere, G. Meijer
Publikováno v:
European Journal of Cancer, 32A(11), 2011-2018. ELSEVIER SCI LTD
In order to simulate drug resistance observed in the clinic, two cisplatin-resistant cell lines were produced fi om a murine ovarian reticulosarcoma, M5076 (M5), by pulse (MS/CDDP) and continuous (M5/CDDPc) treatment with cis-diamminedichloroplatinum
Autor:
Maurizio D'Incalci, M Grandi, E Pesenti, Giorgio Belvedere, Giovanna Tagliabue, Massimo Broggini, G Pennella, Cristina Geroni
Publikováno v:
British Journal of Cancer
We investigated the mechanism of resistance in murine L1210 leukaemia cells selected after treatment with FCE 23762 methoxymorpholinyl doxorubicin: (MMRDX), a methoxymorpholinyl derivative of doxorubicin active in vitro and in vivo on multidrug-resis
Autor:
Michele Samaja, Giorgio Belvedere
Publisher Summary Hemoglobin (Hb) has several enzymatic activities, besides its properties as an O 2 carrier. Styrene is an olefin monomer used widely in the production of plastics, resins, and synthetic rubber. The first step of styrene metabolism i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b353717ebd54a92870f2faf1f96b1fc6
https://doi.org/10.1016/0076-6879(94)31041-6
https://doi.org/10.1016/0076-6879(94)31041-6
Publikováno v:
Cancer chemotherapy and pharmacology. 25(6)
The effects of mitoxantrone (Mx) and doxorubicin (Dx) on cytotoxicity and DNA damage as assayed by alkaline elution were studied in two human colon adenocarcinoma cell lines sensitive (LoVo) and resistant (LoVo/Dx) to doxorubicin. Mx was more cytotox
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 1:25-34
The highly sensitive and specific combination of a gas chromatographic procedure with mass fragmentographic detection was adopted in order to determine the nanogram concentration of reserpine-like material persisting in rat brain, with more adequate
Publikováno v:
Biochemical Pharmacology. 29:1693-1702
The catalytic activities of hepatic microsomes from untreated, phenobarbital-treated and 3- methylcholanthrene-treated adult rabbits with respect to benzo(a)pyrene hydroxylation and the acti- vation of (-)truns-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene
Publikováno v:
Toxicology Letters. 23:261-265
The oxidation of styrene to styrene oxide was studied in the isolated perfused rat liver in the presence and absence of blood at styrene concentrations of 2.5 and 50 mM. Erythrocytes contained in whole blood increased the levels of styrene glycol abo
Autor:
Maurizio D'Incalci, Antonio Suarato, Fernando C. Guiliani, Giorgio Belvedere, Cristina Geroni
Publikováno v:
Biochemical Pharmacology. 38:3713-3721
Formation of DNA single strand breaks (SSB) was assayed by alkaline elution in LoVo cells treated with doxorubicin, daunorubicin and six derivatives of these drugs modified either in the chromophore or the sugar. Seven compounds showed a biphasic rel
Publikováno v:
Chemico-Biological Interactions. 27:313-321
When styrene oxide was incubated with glutathione in the presence of rat liver cytosolic fraction, two conjugates were formed. Structural investigation by mass spectrometry (MS), proton magnetic resonance (PMR) analysis and chemical fragmentation sho
Publikováno v:
Journal of Pharmaceutical Sciences. 65:810-815
The 10,11-epoxide, 10-hydroxy, and 10,11-dihydrodiol metabolites of protriptyline were identified in rat urine collected after the administration of 40 mg/kg ip of protriptyline. Mass spectrometric characterization confirmed the structure of these me