Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Giorgio Attardo"'
Autor:
Krister Bokvist, Donalyn Scheuner, Steven E. Kahn, Yin-Guo Lin, Daniel T. Meier, Patrick J. Gillespie, Giorgio Attardo, Tami Wolden-Hanson, Rebecca L. Hull, Kelly Conway, Andrew T. Templin, Joshua R. Willard
Publikováno v:
Diabetologia. 61:2215-2224
Islet amyloid deposits contribute to beta cell dysfunction and death in most individuals with type 2 diabetes but non-invasive methods to determine the presence of these pathological protein aggregates are currently not available. Therefore, we exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::992f42e5ea35d99813bd6d3cecc9d333
https://doi.org/10.1007/s00125-018-4695-y
https://doi.org/10.1007/s00125-018-4695-y
Autor:
Yin-Guo Lin, Carey Horchler, Felipe Gomez, Jason Goodman, Qianwa Liang, Kelly Conway, Lois Lazor, Giorgio Attardo, Brian P. Lieberman, Jennifer Clemens, Mark A. Mintun
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89efc117d4874ea5b871b9c512db49ba
https://doi.org/10.1016/j.jalz.2017.07.081
https://doi.org/10.1016/j.jalz.2017.07.081
Autor:
Paul Isenring, Mariève Jacob-Wagner, Marc J. Bergeron, Jeffrey A. M. Coull, Guillaume Lavertu, Lionel Dumas, Sasmita Tripathy, Giorgio Attardo, Annie Castonguay, Irenej Kianicka, Christian Tardif, Karine Bachand, Robert P. Bonin, Martin Gagnon, Jimena Perez-Sanchez, Yves De Koninck, Bin Wang, Isabelle Valade, Dominic Boudreau
Publikováno v:
Nature Medicine. 19:1524-1528
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6775e4833793b5f96edcd0fe890f15f6
https://doi.org/10.1038/nm.3356
https://doi.org/10.1038/nm.3356
Autor:
Nancy Kant, Xiyun Chai, Kelly Conway, Bradley B. Miller, Suchira Bose, Jing Xu, Giorgio Attardo, Jeffrey L. Dage
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16415ee2238893180a00b17c35afd1c8
https://doi.org/10.1016/j.jalz.2016.06.1729
https://doi.org/10.1016/j.jalz.2016.06.1729
Autor:
Adam T. Hoye, Martin G. Pomper, Xing Yang, Ying Chen, Sridhar Nimmagadda, Ronnie C. Mease, Mrudula Pullambhatla, Hassan M. Shallal, Ala Lisok, Yuchuan Wang, Giorgio Attardo, Hannah Edelman, Catherine A. Foss
Publikováno v:
Journal of medicinal chemistry. 59(1)
Radiolabeled urea-based low-molecular weight inhibitors of the prostate-specific membrane antigen (PSMA) are under intense investigation as imaging and therapeutic agents for prostate and other cancers. In an effort to provide agents with less nontar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7491001a1867593fd615eff9c1306d2
https://pubmed.ncbi.nlm.nih.gov/26629713
https://pubmed.ncbi.nlm.nih.gov/26629713
Autor:
Shailaja Kasibhatla, Ben Tseng, Real Denis, Candace Crogan-Grundy, Serge Lamothe, Henriette Gourdeau, Songchun Jiang, Charles Blais, Giorgio Attardo, Hong Zhang, John Drewe, William Kemnitzer, Sui Xiong Cai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5571-5575
As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as potential anticancer agents, we explored the removal of the chiral center at the 4-position and prepared a series of 4-aryl-2-oxo-2H-chromenes. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8c740ef28fc8921e0203147a1fe4f
https://doi.org/10.1016/j.bmcl.2008.09.011
https://doi.org/10.1016/j.bmcl.2008.09.011
Autor:
Sui Xiong Cai, Serge Lamothe, Candace Crogan-Grundy, Shailaja Kasibhatla, Monica Bubenik, William Kemnitzer, John Drewe, Henriette Gourdeau, Giorgio Attardo, Yan Wang, Songchun Jiang, Real Denis, Denis Labrecque, Ben Tseng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:603-607
As a continuation of our efforts to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored modifications at the 2- and 3-positions. It was found that replacement of the 3-cyano group by an ester, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70262a5ac2a1c032f34601b9f972304f
https://doi.org/10.1016/j.bmcl.2007.11.078
https://doi.org/10.1016/j.bmcl.2007.11.078
Autor:
Giorgio Attardo, Hui Xiong, Nathaniel C. Lim, Jennifer Clemens, Ximin Li, Kuo-Hsien Fan, Adam T. Hoye, Carey Horchler
Publikováno v:
ChemInform. 46
Starting from pyridine N-oxides the formation of various 2-trialkylammonium salts is examined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b3b630b81c7a7d447bd25e892ceb3c
https://doi.org/10.1002/chin.201549035
https://doi.org/10.1002/chin.201549035
Autor:
Ximin Li, Nathaniel C. Lim, Kuo-Hsien Fan, Jennifer Clemens, Carey Horchler, Hui Xiong, Giorgio Attardo, Adam T. Hoye
Publikováno v:
Organic letters. 17(15)
Among known precursors for 2-[(18)F]fluoropyridines, pyridyltrialkylammonium salts have shown excellent reactivity; however, their broader utility has been limited because synthetic methods for their preparation suffer from poor functional group comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0eb5bc2ba4dc390088fc2b635dc725
https://pubmed.ncbi.nlm.nih.gov/26193373
https://pubmed.ncbi.nlm.nih.gov/26193373
Autor:
Lifen Xu, Shailaja Kasibhatla, Nancy Barriault, Denis Labrecque, Jennifer Dodd, Louis Vaillancourt, Shaojuan Jia, Henriette Gourdeau, Serge Lamothe, Ben Tseng, Songchun Jiang, Sui Xiong Cai, Candace Crogan-Grundy, John Drewe, Giorgio Attardo, William Kemnitzer, Real Denis, Sylvie Charron, Hong Zhang, Jianghong Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4745-4751
As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9522c973941ac52dd25011ac57c2427
https://doi.org/10.1016/j.bmcl.2005.07.066
https://doi.org/10.1016/j.bmcl.2005.07.066