Výsledky vyhledávání - "Giorgio Stefancich"

A New Class of Antifungal Agents. Synthesis and Antimycotic Activity of DisubstitutedN-Azolylamines

Autor: Chiara Musiu, Giorgio Stefancich, Paolo La Colla, Sabrina Castellano

Publikováno v: Archiv der Pharmazie. 333:299-304

In this study we extended our exploration of the N-azolylamine moiety for its antifungal activity. We prepared a number of N-azolylamino derivatives. The synthetic sequence includes the preparation of aminoazole Schiff bases, and the reduction and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b60d1257ea931f35157cfc3a4fb4dee8
https://doi.org/10.1002/1521-4184(20009)333:9<299::aid-ardp299>3.0.co

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Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans

Autor: Ilaria Granata, David C. Lamb, Andrew G. S. Warrilow, Giorgio Stefancich, Marisabella Santoriello, Bruno Maresca, Amalia Porta, Steven L. Kelly, Sabrina Castellano, Cristina Sgherri, Ciro Milite, Lucia Calucci, Elena Concetta Calabrese, Gianluca Sbardella, Mike Frank Quartacci

Publikováno v: Journal of antimicrobial chemotherapy
68 (2013): 1111–1119. doi:10.1093/jac/dks506
info:cnr-pdr/source/autori:Calabrese, EC; Castellano, S; Santoriello, M; Sgherri, C; Quartacci, MF; Calucci, L; Warrilow, AGS; Lamb, DC; Kelly, SL; Milite, C; Granata, I; Sbardella, G ; Stefancich, G; Maresca, B; Porta, A/titolo:Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and-resistant strains of Candida albicans/doi:10.1093%2Fjac%2Fdks506/rivista:Journal of antimicrobial chemotherapy (Print)/anno:2013/pagina_da:1111/pagina_a:1119/intervallo_pagine:1111–1119/volume:68

OBJECTIVES: In this study we investigated the in vitro fungistatic and fungicidal activities of CPA18 and CPA109, two azole compounds with original structural features, alone and in combination with fluconazole against fluconazole-susceptible and -re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bade3fa803b316a6005d3a6a4474308
https://cronfa.swan.ac.uk/Record/cronfa14005

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5H-pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A novel class of non-nucleoside reverse transcriptase inhibitors

Autor: Maria Grazia Spiga, Anna Giulia Loi, Romano Silvestri, Silvio Massa, M. Putzolu, Simona Corrias, Paolo La Colla, E. Pagnozzi, Marino Artico, Giorgio Stefancich

Publikováno v: Bioorganic & Medicinal Chemistry. 4:837-850

With the aim of developing novel inhibitors of human immunodeficiency virus, various derivatives (10-17) related to 5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepine (PBTD) were prepared and tested in vitro. The title tricyclic derivatives were obtained by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837a63ab997b022c67a0cfbe5e0173bb
https://doi.org/10.1016/0968-0896(96)00075-2

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Synthesis of Pyrryl Aryl Sulfones Targeted at the HIV-1 Reverse Transcriptase

Autor: Marino Artico, Romano Silvestri, Giorgio Stefancich, E. Pagnozzi, P. La Colla, D. Musu, E. Tinti, Silvio Massa, Elisabetta Pinna, F. Scintu

Publikováno v: Archiv der Pharmazie. 328:223-229

Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c7328ecf165ff84416d40e57dbe86d
https://doi.org/10.1002/ardp.19953280304

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Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein

Autor: Ciro Milite, Giorgio Stefancich, Claudia Martini, Elisa Rizzetto, Eleonora Da Pozzo, S Bendinelli, Federico Da Settimo, Barbara Costa, Sabrina Taliani, Sandro Cosconati, Giovanni Greco, Isabella Pugliesi, Ettore Novellino, Gianluca Sbardella, Sabrina Castellano

A series of novel 4-phenylquinazoline-2-carboxamides (1-58) were designed as aza-isosters of PK11195, the well-known 18 kDa translocator protein (TSPO) reference ligand, and synthesized by means of a very simple and efficient procedure. A number of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea339886a20670d2c694f561e90338b
http://hdl.handle.net/11591/187321

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Heterocycles With a Benzothiadiazepine Moiety. IV. Synthesis of Novel Tetracyclic Rings by Intramolecular Cyclization of 10-Bromoacetyl-10,11-dihydro-11-ethoxycarbonyl-pyrrolo[1,2-b] [1,2,5] Benzothiadiazepine 5,5-Dioxide and Its Derivatives

Autor: Giorgio Stefancich, Marino Artico, E. Pagnozzi, Romano Silvestri

Publikováno v: Synthetic Communications. 24:2685-2695

Two novel tetracyclic derivatives, namely 5 and 8, have been synthesized by intramolecular cyclization of the 10-bromoacetyl-10,11-dihydro-11-ethoxycarbonylpyrrolo[1,2-b] [1,2,5]benzothiadiazepine 5,5-dioxide (3) and, respectively, the bis-methylamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88f1094aa1a93fa8999cb748bf435540
https://doi.org/10.1080/00397919408010583

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Heterocycles with a benzothiadiazepine moiety.3.Synthesis of imidazo[5,1-d]pyrrolo[1,2-b][1,2,5]benzothiadiazepine 9,9-dioxide

Autor: E. Pagnozzi, Romano Silvestri, Giorgio Stefancich, Marino Artico

Publikováno v: Journal of Heterocyclic Chemistry. 31:1033-1036

The synthesis of imidazo[5,1-d]pyrrolo[1,2-b][1,2,5]benzothiadiazepine 9,9-dioxide (5), a novel sulfur-containing tetracyclic benzodiazepine, is reported starting from pyrrolo[1,2-b][1,2,5]benzothiadiazepine 5,5-diox-ide (6) by cycloaddition of tosyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7aa8a9504fa804d8c336a5c699c06270
https://doi.org/10.1002/jhet.5570310456

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New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R)

Autor: Federico Berti, Laura Mennuni, Lucia Lassiani, Flora Ferrari, Alessia Ciogli, Francesco Makovec, Daniel Fourmy, Antonio Varnavas, Chantal Escrieut, Giorgio Stefancich, Francesco Gasparrini, Esther Marco, Michela V. Pavan

The anthranilic acid diamides represent the most recent class of nonpeptide CCK(1) receptor (CCK(1)-R) antagonists. Herein we describe the second phase of the anthranilic acid C-terminal optimization using nonproteinogenic amino acids containing a ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d53c4bddd1e8d47f015714250acdc23
http://hdl.handle.net/11573/390098

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Research on nitrogen containing heterocyclic compounds.XIX: Synthesis of 8H-imidazo[2,1-c]-s-triazolo[4,3-a]-[1,4]benzodiazepine and its 1-derivatives

Autor: Giorgio Stefancich, Romano Silvestri, Marino Artico

Publikováno v: Journal of Heterocyclic Chemistry. 30:529-532

Reaction of 2-nitrobenzyl iodide with 1H-imidazole, in the presence of potassium tert-butoxide and 18-crown-6, gave 1-(2-nitrobenzyl)-1H-imidazole. Trichloroacetylation of this compound furnished trichloroacet-ylimidazole 8, which on treatment with s

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https://doi.org/10.1002/jhet.5570300243

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