Výsledky vyhledávání - "Giorgio, Ramadori"

Akademický článek

ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer

Autor: Chiara Pozzato, Gonçalo Outeiro-Pinho, Mirco Galiè, Giorgio Ramadori, Georgia Konstantinidou

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2402-2426 (2024)

Abstract Mutated KRAS serves as the oncogenic driver in 30% of non-small cell lung cancers (NSCLCs) and is associated with metastatic and therapy-resistant tumors. Focal Adhesion Kinase (FAK) acts as a mediator in sustaining KRAS-driven lung tumors,

Externí odkaz: https://doaj.org/article/6d906eadefba4aea98f43f8cb1de0cbe

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Akademický článek

Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Excess ketogenesis can lead to ketoacidosis, a serious complication in patients with diabetes. Here the authors report an insulin independent pathway, the hepatic nonparenchymal S100A9-TLR4-mTORC1 axis, that is able to normalize diabetic ketogenesis

Externí odkaz: https://doaj.org/article/8ed9f595195e400f85d854d78ace7d95

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Akademický článek

S100A9 extends lifespan in insulin deficiency

Autor: Giorgio Ramadori, Sanda Ljubicic, Serena Ricci, Despoina Mikropoulou, Xavier Brenachot, Christelle Veyrat-Durebex, Ebru Aras, Rafael M. Ioris, Jordi Altirriba, Elisabeth Malle, Dirk Foell, Thomas Vogl, Roberto Coppari

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Insulin replacement is a valuable therapy for insulin deficiency, however, other therapies are being investigated to restore metabolic homeostasis. Here, the authors identify S100A9 as a leptin induced circulating cue that improves glucose and lipid

Externí odkaz: https://doaj.org/article/d8ef89e1a35d49b49dd4c3ecbbce6524

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Akademický článek

FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth

Autor: Giorgio Ramadori, Rafael M. Ioris, Zoltan Villanyi, Raquel Firnkes, Olesya O. Panasenko, George Allen, Georgia Konstantinidou, Ebru Aras, Xavier Brenachot, Tommasina Biscotti, Anne Charollais, Michele Luchetti, Fedor Bezrukov, Alfredo Santinelli, Muntaha Samad, Pierre Baldi, Martine A. Collart, Roberto Coppari

Publikováno v: Cell Reports, Vol 30, Iss 11, Pp 3851-3863.e6 (2020)

Summary: Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isomer

Externí odkaz: https://doaj.org/article/5d5801df434442c3b701f289a27b0a29

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Akademický článek

Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

Autor: Xavier Brenachot, Giorgio Ramadori, Rafael M. Ioris, Christelle Veyrat-Durebex, Jordi Altirriba, Ebru Aras, Sanda Ljubicic, Daisuke Kohno, Salvatore Fabbiano, Sophie Clement, Nicolas Goossens, Mirko Trajkovski, Sheila Harroch, Francesco Negro, Roberto Coppari

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

During obesity, chronic inflammation leads to insulin resistance and diabetes. Here, Brenachot et al. show that Protein Tyrosine Phosphatase Receptor Gamma is upregulated in obesity by inflammatory signals and correlates with insulin resistance in hu

Externí odkaz: https://doaj.org/article/c9087c97e4584399b00b49105c3d6c1d

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Akademický článek

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity

Autor: Rafael M. Ioris, Mirco Galié, Giorgio Ramadori, Jason G. Anderson, Anne Charollais, Georgia Konstantinidou, Xavier Brenachot, Ebru Aras, Algera Goga, Nicholas Ceglia, Carlos Sebastián, Denis Martinvalet, Raul Mostoslavsky, Pierre Baldi, Roberto Coppari

Publikováno v: Cell Reports, Vol 18, Iss 8, Pp 1858-1868 (2017)

Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutations that a

Externí odkaz: https://doaj.org/article/e7cf775d005b4cbea795b0e078e48453

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Akademický článek

Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons

Autor: Ebru Aras, Giorgio Ramadori, Kenichiro Kinouchi, Yu Liu, Rafael M. Ioris, Xavier Brenachot, Sanda Ljubicic, Christelle Veyrat-Durebex, Silvia Mannucci, Mirco Galié, Pierre Baldi, Paolo Sassone-Corsi, Roberto Coppari

Publikováno v: Cell Reports, Vol 27, Iss 8, Pp 2385-2398.e3 (2019)

Summary: Loss of synchrony between geophysical time and insulin action predisposes to metabolic diseases. Yet the brain and peripheral pathways linking proper insulin effect to diurnal changes in light-dark and feeding-fasting inputs are poorly under

Externí odkaz: https://doaj.org/article/7bf84bd976e1468ca62e2d4016c78a01

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