Neuroprotective role of plumbagin on eye damage induced by high-sucrose diet in adult fruit fly Drosophila melanogaster

Autor: Elisabetta Catalani, Simona Del Quondam, Kashi Brunetti, Agnese Cherubini, Silvia Bongiorni, Anna Rita Taddei, Silvia Zecchini, Matteo Giovarelli, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Giorgio Prantera, Davide Cervia

Publikováno v: Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115298- (2023)

The natural compound plumbagin has a wide range of pharmacological and potential therapeutic activities, although its role in neuroretina degeneration is unknown. Here we evaluated the effects of plumbagin on retina homeostasis of the fruit fly Droso

Externí odkaz: https://doaj.org/article/a030f16f1cf54fdcb72c977fbd9dc256

Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars

Autor: Silvia Bongiorni, Ivan Arisi, Brunella Ceccantoni, Cristina Rossi, Camilla Cresta, Simona Castellani, Ivano Forgione, Sara Rinalducci, Rosario Muleo, Giorgio Prantera

Publikováno v: Antioxidants, Vol 11, Iss 11, p 2086 (2022)

Plant-derived polyphenols exhibit beneficial effects on physiological and pathological processes, including cancer and neurodegenerative disorders, mainly because of their antioxidant activity. Apples are highly enriched in these compounds, mainly in

Externí odkaz: https://doaj.org/article/835429bb9c6846e6b81a78dad93d9849

The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents

Autor: Elisabetta Catalani, Federico Buonanno, Gabriele Lupidi, Silvia Bongiorni, Riccardo Belardi, Silvia Zecchini, Matteo Giovarelli, Marco Coazzoli, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Giorgio Prantera, Enrico Marcantoni, Claudio Ortenzi, Anna Maria Fausto, Simona Picchietti, Davide Cervia

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)

We synthesized and characterized MOMO as a new small molecule analog of the cytotoxic natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis of MOMO had a key step in the Wittig olefination for the constructio

Externí odkaz: https://doaj.org/article/8fa3689649214223bf293157792a8fa6

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

Autor: Serena Nicolai, Silvia Filippi, Manuela Caputo, Lubos Cipak, Juraj Gregan, Gustav Ammerer, Mattia Frontini, Daniela Willems, Giorgio Prantera, Adayabalam S Balajee, Luca Proietti-De-Santis

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128558 (2015)

The CSB protein, a member of the SWI/SNF ATP dependent chromatin remodeling family of proteins, plays a role in a sub-pathway of nucleotide excision repair (NER) known as transcription coupled repair (TCR). CSB is frequently mutated in Cockayne syndr

Externí odkaz: https://doaj.org/article/0678e4d2da6742459c2ea3d2eccd3ecf

The Italian National Project of Astrobiology—Life in Space—Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles

Autor: Onofri, Silvano, Balucani, Nadia, Barone, Vincenzo, Benedetti, Pietro, Billi, Daniela, Balbi, Amedeo, Brucato, John Robert, Cobucci-Ponzano, Beatrice, Costanzo, Giovanna, La Rocca, Nicoletta, Moracci, Marco, Saladino, Raffaele, Vladilo, Giovanni, Niccolò, Albertini, Mariano, Battistuzzi, Julien, Bloino, Lorenzo, Botta, Piergiorgio, Casavecchia, Alessia, Cassaro, Riccardo, Claudi, Lorenzo, Cocola, Alberto, Coduti, Paola Di Donato, Ernesto Di Mauro, Luca, Dore, Stefano, Falcinelli, Marco, Fulle, Stavro, Ivanovski, Andrea, Lombardi, Giordano, Mancini, Michele, Maris, Luisa, Maurelli, Giuseppe, Murante, Rodolfo, Negri, Claudia, Pacelli, Isabella, Pagano, Davide, Piccinino, Luca, Poletto, Giorgio, Prantera, Cristina, Puzzarini, Sergio, Rampino, Caterina, Ripa, Marzio, Rosi, Monica, Sanna, Laura, Selbmann, Laura, Silva, Dimitrios, Skouteris, Andrea, Strazzulli, Nicola, Tasinato, Anna Maria Timperio, Andrea, Tozzi, Gian Paolo Tozzi, Trainotti, Livio, Piero, Ugliengo, Luigi, Vaccaro, and Laura Zucconi

Publikováno v: Astrobiology
Astrobiology (Larchmt. N.Y.) 20 (2020): 580–582. doi:10.1089/ast.2020.2247
info:cnr-pdr/source/autori:Silvano Onofri,1 Nadia Balucani,2 Vincenzo Barone,3 Piero Benedetti,4,5 Daniela Billi,6 Amedeo Balbi,7 John Robert Brucato,8 Beatrice Cobucci-Ponzano,9 Giovanna Costanzo,10 Nicoletta La Rocca,4 Marco Moracci,9,11 Raffaele Saladino,1 Giovanni Vladilo,12 and the OPPS Project Team*/titolo:The Italian National Project of Astrobiology--Life in Space--Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles/doi:10.1089%2Fast.2020.2247/rivista:Astrobiology (Larchmt. N.Y.)/anno:2020/pagina_da:580/pagina_a:582/intervallo_pagine:580–582/volume:20
info:cnr-pdr/source/autori:Onofri, Silvano; Balucani, Nadia; Barone, Vincenzo; Benedetti, Piero; Billi, Daniela; Balbi, Amedeo; Brucato, John Robert; Cobucci-Ponzano, Beatrice; Costanzo, Giovanna; La Rocca, Nicoletta; Moracci, Marco; Saladino, Raffaele; Vladilo, Giovanni/titolo:The Italian National Project of Astrobiology-Life in Space-Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles/doi:10.1089%2Fast.2020.2247/rivista:Astrobiology (Larchmt. N.Y.)/anno:2020/pagina_da:580/pagina_a:582/intervallo_pagine:580–582/volume:20

THE ''LIfe in Space'' project was funded in the wake of the Italian Space Agency's proposal for the development of a network of institutions and laboratories conceived to implement Italian participation in space astrobiology experiments. Of primary c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c4827ee4fc59637b347063fe9384be
https://doi.org/10.1089/ast.2020.2247