Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Giorgio, Pesciullesi"'
Autor:
Ana S. Ramírez, Mario de Capitani, Giorgio Pesciullesi, Julia Kowal, Joël S. Bloch, Rossitza N. Irobalieva, Jean-Louis Reymond, Markus Aebi, Kaspar P. Locher
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Oligosaccharyltransferase (OST), the central enzyme in N-glycosylation, modifies acceptor proteins by attaching a complex glycan. Cryo-EM structures of OST in distinct states, reveal the molecular basis of substrate recognition and catalysis.
Externí odkaz:
https://doaj.org/article/43b2b3330caf4ca4bdb47a82b87d0d0f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Organic reactions can readily be learned by deep learning models, however, stereochemistry is still a challenge. Here, the authors fine tune a general model using a small dataset, then predict and validate experimentally regio- and stereo-selectivity
Externí odkaz:
https://doaj.org/article/5d394ff268c64ce3b0faabdee491f557
Autor:
Jillianne, Eyring, Chia-Wei, Lin, Elsy Mankah, Ngwa, Jérémy, Boilevin, Giorgio, Pesciullesi, Kaspar P, Locher, Tamis, Darbre, Jean-Louis, Reymond, Markus, Aebi
Publikováno v:
The Journal of Biological Chemistry
Oligosaccharyltransferase (OST) catalyzes the central step in N-linked protein glycosylation, the transfer of a preassembled oligosaccharide from its lipid carrier onto asparagine residues of secretory proteins. The prototypic hetero-octameric OST co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b006d79875207b2c9fa86622672b3bd6
https://pubmed.ncbi.nlm.nih.gov/34023382
https://pubmed.ncbi.nlm.nih.gov/34023382
Organic chemistry is central to society because it enables the synthesis of complex molecules and materials used in all fields of science and technology. The synthetic methods represent a vast body of accumulated knowledge optimally suited for deep l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1884b82c782f97c729746243e956e3c
https://doi.org/10.26434/chemrxiv.11935635.v1
https://doi.org/10.26434/chemrxiv.11935635.v1
Autor:
Tamis Darbre, Markus Aebi, Jean-Louis Reymond, Kamil Nosol, Giorgio Pesciullesi, Rossitza N. Irobalieva, Kaspar P. Locher, Jérémy Boilevin, Anthony A. Kossiakoff, Joël S. Bloch
Publikováno v:
Nature
Nature, 579
Nature, 579
In eukaryotic protein N-glycosylation, a series of glycosyltransferases catalyse the biosynthesis of a dolichylpyrophosphate-linked oligosaccharide before its transfer onto acceptor proteins1. The final seven steps occur in the lumen of the endoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc7e8375c337bda406f32a9ecc4674f