Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Giorgio, Napolitani"'
Autor:
Sila Gerlevik, Nogayhan Seymen, Shan Hama, Warisha Mumtaz, I Richard Thompson, Seyed R Jalili, Deniz E Kaya, Alfredo Iacoangeli, Andrea Pellagatti, Jacqueline Boultwood, Giorgio Napolitani, Ghulam J Mufti, Mohammad M Karimi
Publikováno v:
eLife, Vol 13 (2024)
Mutational profiles of myelodysplastic syndromes (MDS) have established that a relatively small number of genetic aberrations, including SF3B1 and SRSF2 spliceosome mutations, lead to specific phenotypes and prognostic subgrouping. We performed a mul
Externí odkaz:
https://doaj.org/article/3ee4a561cd2144888814648747b54fd4
Autor:
Dmitri Kazmin, Elizabeth A. Clutterbuck, Giorgio Napolitani, Amanda L. Wilkins, Andrea Tarlton, Amber J. Thompson, Emmanuele Montomoli, Guilia Lapini, Smiti Bihari, Rachel White, Claire Jones, Matthew D. Snape, Ushma Galal, Ly-Mee Yu, Rino Rappuoli, Giuseppe Del Giudice, Andrew J. Pollard, Bali Pulendran
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract The pediatric population receives the majority of vaccines globally, yet there is a paucity of studies on the transcriptional response induced by immunization in this special population. In this study, we performed a systems-level analysis o
Externí odkaz:
https://doaj.org/article/e08bd682474d4f25b313914b68f1c30c
Autor:
Victoria K. Woodcock, Ji‐Li Chen, Karin Purshouse, Chrissie Butcher, Linda Collins, Caroline Haddon, Gillian Verrall, Leena Elhussein, Corran Roberts, Andrea Tarlton, Margarida Rei, Giorgio Napolitani, Mariolina Salio, Mark R. Middleton, Vincenzo Cerundolo, Jeremy Crew, Andrew S. Protheroe
Publikováno v:
BJUI Compass, Vol 4, Iss 3, Pp 322-330 (2023)
Abstract Objectives This study aimed to investigate the anti‐PD‐1 inhibitor pembrolizumab as a potential agent for use in non‐muscle‐invasive bladder cancer (NMIBC) by conducting a Phase 1 safety run‐in study to assess the safety and tolera
Externí odkaz:
https://doaj.org/article/d7395c1210aa4beeac995f4f6e98382c
Autor:
Florian A. Bach, Diana Muñoz Sandoval, Michalina Mazurczyk, Yrene Themistocleous, Thomas A. Rawlinson, Adam C. Harding, Alison Kemp, Sarah E. Silk, Jordan R. Barrett, Nick J. Edwards, Alasdair Ivens, Julian C. Rayner, Angela M. Minassian, Giorgio Napolitani, Simon J. Draper, Philip J. Spence
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
BACKGROUND The biology of Plasmodium vivax is markedly different from that of P. falciparum; how this shapes the immune response to infection remains unclear. To address this shortfall, we inoculated human volunteers with a clonal field isolate of P.
Externí odkaz:
https://doaj.org/article/d31b6e682890476cba7fb42065b54f54
Autor:
Sarah Mackie, Matthew Sadler, Douglas Silveira, Hosanna Assefa-Kebede, Pilar Casares Alaez, Giorgio Napolitani, Aleksander Ivetic, Daniel Bromage, Lynn Quek
Publikováno v:
HemaSphere, Vol 7, p e4809599 (2023)
Externí odkaz:
https://doaj.org/article/d50c407ff01c49b0b0dc37411982196f
Autor:
Anna Aulicino, Agne Antanaviciute, Joe Frost, Ana Sousa Geros, Esther Mellado, Moustafa Attar, Marta Jagielowicz, Philip Hublitz, Julia Sinz, Lorena Preciado-Llanes, Giorgio Napolitani, Rory Bowden, Hashem Koohy, Hal Drakesmith, Alison Simmons
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Aulicino, Antanaviciute et al investigate the transcriptional response to invasive Salmonella strains in dendritic cells (DCs). They show that S. Typhi mount a response against nitrosative stress pathways and propose a role of iron uptake and transpo
Externí odkaz:
https://doaj.org/article/26c225ac2f684651825e4bab14553e42
Autor:
Deborah L. Cross, Marije K. Verheul, Michael D. Leipold, Gerlinde Obermoser, Celina Jin, Elizabeth Jones, Joshua S. Starr, Irina Mohorianu, Christoph J. Blohmke, Holden T. Maecker, Giorgio Napolitani, Jennifer Hill, Andrew J. Pollard
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Vi-polysaccharide conjugate vaccines are efficacious against cases of typhoid fever; however, an absolute correlate of protection is not established. In this study, we investigated the leukocyte response to a Vi-tetanus toxoid conjugate vaccine (Vi-T
Externí odkaz:
https://doaj.org/article/18154f04f8854243816e5256d03d16db
Autor:
Chloe H. Lee, Mariana Pereira Pinho, Paul R. Buckley, Isaac B. Woodhouse, Graham Ogg, Alison Simmons, Giorgio Napolitani, Hashem Koohy
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
While individuals infected with coronavirus disease 2019 (COVID-19) manifested a broad range in susceptibility and severity to the disease, the pre-existing immune memory to related pathogens cross-reactive against SARS-CoV-2 can influence the diseas
Externí odkaz:
https://doaj.org/article/cb5d6cdd7c3f41198aaa107f502f7680
Autor:
Malick M Gibani, Celina Jin, Sonu Shrestha, Maria Moore, Lily Norman, Merryn Voysey, Elizabeth Jones, Luke Blackwell, Helena Thomaides-Brears, Jennifer Hill, Christoph J Blohmke, Hazel C Dobinson, Philip Baker, Claire Jones, Danielle Campbell, Yama F Mujadidi, Emma Plested, Lorena Preciado-Llanes, Giorgio Napolitani, Alison Simmons, Melita A Gordon, Brian Angus, Thomas C Darton, Vincenzo Cerundulo, Andrew J Pollard
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008783 (2020)
Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood. Prior exposure is thought to confer partial, but incomplete, p
Externí odkaz:
https://doaj.org/article/f70f1ff1116542f5a775b4d8d3b849ca
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, ther
Externí odkaz:
https://doaj.org/article/7ebdfb8b811347709b53843cc76d9ae5