Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Giorgia Vicentini"'
Autor:
Heather Hobbs, Rick P. C. Cousins, Caroline Whitworth, Ruth R. Osborn, Cesar Ramirez-Molina, Giorgia Vicentini, Chris Ioannou, Chun-wa Chung, Jeremy John Payne, Michelle L. Heathcote, Michael David Barker, Sebastien Andre Campos, Paul Faulder, Mary A. Morse, William L. Rumsey, John Liddle, Daniel Terence Tape, John Martin Pritchard, Rick Williamson, Duncan S. Holmes, Paul Bamborough
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5222-5226
The lead optimization of a series of potent azaindole IKK2 inhibitors is described. Optimization of the human whole blood activity and selectivity over IKK1 in parallel led to the discovery of 16, a potent and selective IKK2 inhibitor showing good ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c01094b7cd1f9f02ade498d99ac86e
https://doi.org/10.1016/j.bmcl.2012.06.065
https://doi.org/10.1016/j.bmcl.2012.06.065
Autor:
Sophie Quevillon-Cheruel, Nicolas Leulliot, Jozef Goris, David Barford, Giorgia Vicentini, M. Schiltz, Herman van Tilbeurgh, Jan Jordens
Publikováno v:
Molecular Cell. 23(3):413-424
PTPA, an essential and specific activator of protein phosphatase 2A (PP2A), functions as a peptidyl prolyl isomerase (PPIase). We present here the crystal structures of human PTPA and of the two yeast orthologs (Ypa1 and Ypa2), revealing an all alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b323e6ae171d1520d74ee4ab23ea0b
Publikováno v:
EMBO reports. 4(11)
In eukaryotes, a family of six homologous minichromosome maintenance (MCM) proteins has a key function in ensuring that DNA replication occurs only once before cell division. Whereas all eukaryotes have six paralogues, in some Archaea a single protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73f27c7f901c002205b7e45c0ae56a6
https://pubmed.ncbi.nlm.nih.gov/14566326
https://pubmed.ncbi.nlm.nih.gov/14566326