Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Giorgia Salvagiotto"'
Autor:
Giorgia Salvagiotto, Sarah Burton, Christine A Daigh, Deepika Rajesh, Igor I Slukvin, Nicholas J Seay
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17829 (2011)
Human ESC and iPSC are an attractive source of cells of high quantity and purity to be used to elucidate early human development processes, for drug discovery, and in clinical cell therapy applications. To efficiently differentiate pluripotent cells
Externí odkaz:
https://doaj.org/article/093a2007a4a64ebea68d58c365067aa7
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106845
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1691992b7d4d93c15eba9ca91850f9b9
https://doi.org/10.1016/j.vascn.2020.106845
https://doi.org/10.1016/j.vascn.2020.106845
Autor:
Qiong Sun, Anja Ebert, Markus Jaritz, Meinrad Busslinger, Ido Tamir, Shane McManus, Giorgia Salvagiotto, Jasna Medvedovic, Hiromi Tagoh
Publikováno v:
The EMBO Journal. 30:2388-2404
Pax5 is a critical regulator of B-cell commitment. Here, we identified direct Pax5 target genes by streptavidin-mediated ChIP-chip analysis of pro-B cells expressing in vivo biotinylated Pax5. By binding to promoters and enhancers, Pax5 directly regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6849a2b848d4be3c351b94538978316
https://doi.org/10.1038/emboj.2011.140
https://doi.org/10.1038/emboj.2011.140
Autor:
Giorgia Salvagiotto, Maria Novatchkova, Meinrad Busslinger, Ido Tamir, Anja Ebert, Jasna Medvedovic, Andreas Sommer, Shane McManus, Hiromi Tagoh, Markus Jaritz
Publikováno v:
Immunity. 34:175-187
V(H)-DJ(H) recombination of the immunoglobulin heavy chain (Igh) locus is temporally and spatially controlled during early B cell development, and yet no regulatory elements other than the V(H) gene promoters have been identified throughout the entir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d403c737f08a4c9a9c3ec5b7415a52ae
https://doi.org/10.1016/j.immuni.2011.02.005
https://doi.org/10.1016/j.immuni.2011.02.005
Autor:
Kim Smuga-Otto, James A. Thomson, Maxim A. Vodyanik, William M. Rehrauer, Kyung Dal Choi, Giorgia Salvagiotto, Junying Yu, Igor I. Slukvin
Publikováno v:
Stem Cells. 27:559-567
Induced pluripotent stem cells (iPSCs) provide an unprecedented opportunity for modeling of human diseases in vitro, as well as for developing novel approaches for regenerative therapy based on immunologically compatible cells. In this study, we empl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6654ec18c6452c7308731566067a12d4
https://doi.org/10.1634/stemcells.2008-0922
https://doi.org/10.1634/stemcells.2008-0922
Autor:
David G. Schatz, Bu Yin, Yanhong Ji, Jacques Ghysdael, Susannah L. Hewitt, Craig H. Bassing, Michael A. Farrar, Meinrad Busslinger, Jane A. Skok, Giorgia Salvagiotto, Laura B. Ramsey, Barry P. Sleckman, Jeannette Tenthorey, Julie Chaumeil, Katarzyna Marszalek, Natalie C. Steinel
Publikováno v:
Nature immunology
Coordinated recombination of homologous antigen receptor loci is thought to be important for allelic exclusion. Here we show that homologous immunoglobulin alleles pair in a stage-specific way that mirrors the recombination patterns of these loci. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85d5b4ce681a3daa456c0ae9a95ff69
http://europepmc.org/articles/PMC2693356
http://europepmc.org/articles/PMC2693356
Autor:
Ron Stewart, Igor I. Slukvin, Victor Ruotti, Yun Zhao, Giorgia Salvagiotto, Connie J. Eaves, Maxim A. Vodyanik, James A. Thomson, Marco A. Marra
Publikováno v:
Experimental Hematology. 36:1377-1389
Objective Cellular and molecular changes that occur during the genesis of the hematopoietic system and hematopoietic stem cells in the human embryo are mostly inaccessible to study and remain poorly understood. To address this gap we have exploited t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61a170ec45d99f46cdbfb9cfc7269e1
https://doi.org/10.1016/j.exphem.2008.06.015
https://doi.org/10.1016/j.exphem.2008.06.015
Autor:
Shane McManus, Giorgia Salvagiotto, Alessio Delogu, Alexandra Schebesta, Georg A. Busslinger, Meinrad Busslinger
Publikováno v:
Immunity. 27(1):49-63
SummaryThe transcription factor Pax5 represses B lineage-inappropriate genes and activates B cell-specific genes in B lymphocytes. Here we have identified 170 Pax5-activated genes. Conditional mutagenesis demonstrated that the Pax5-regulated genes re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b12f6a08f9e5c6c57c9a2c816f1b35
Autor:
Giorgia Salvagiotto, Nicola K. Wilson, Deborah Clarke, Constanze Bonifer, Hiromi Tagoh, Richard Ingram, Meinrad Busslinger, Alan J. Warren
Publikováno v:
The EMBO Journal. 25:1070-1080
The transcription factor Pax5 (BSAP) is required for the expression of a B-cell-specific genetic program and for B-cell differentiation, and also to suppress genes of alternative lineages. The molecular mechanism by which repression of myeloid genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b2abf5a2b2d402f6f3592eb3b075ff
https://doi.org/10.1038/sj.emboj.7600997
https://doi.org/10.1038/sj.emboj.7600997
Autor:
Esther Roldan, Abdallah Souabni, Jane A. Skok, Giorgia Salvagiotto, Martin Fuxa, Meinrad Busslinger
Publikováno v:
Genesdevelopment. 18(4)
The subnuclear location and chromatin state of theimmunoglobulin heavy-chain(IgH) locus have been implicated in the control ofV(D)Jrecombination.VH-to-DJHrearrangement of distal, but not proximalVHgenes, furthermore, depends on the B-lineage commitme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54daddc01aa4d3e6d4efe3c84f8cda9b
https://pubmed.ncbi.nlm.nih.gov/15004008
https://pubmed.ncbi.nlm.nih.gov/15004008